68 research outputs found
Thermal Heating in ReRAM Crossbar Arrays: Challenges and Solutions
Increasing popularity of deep-learning-powered applications raises the issue
of vulnerability of neural networks to adversarial attacks. In other words,
hardly perceptible changes in input data lead to the output error in neural
network hindering their utilization in applications that involve decisions with
security risks. A number of previous works have already thoroughly evaluated
the most commonly used configuration - Convolutional Neural Networks (CNNs)
against different types of adversarial attacks. Moreover, recent works
demonstrated transferability of the some adversarial examples across different
neural network models. This paper studied robustness of the new emerging models
such as SpinalNet-based neural networks and Compact Convolutional Transformers
(CCT) on image classification problem of CIFAR-10 dataset. Each architecture
was tested against four White-box attacks and three Black-box attacks. Unlike
VGG and SpinalNet models, attention-based CCT configuration demonstrated large
span between strong robustness and vulnerability to adversarial examples.
Eventually, the study of transferability between VGG, VGG-inspired SpinalNet
and pretrained CCT 7/3x1 models was conducted. It was shown that despite high
effectiveness of the attack on the certain individual model, this does not
guarantee the transferability to other models.Comment: 18 page
AudioFool: Fast, Universal and synchronization-free Cross-Domain Attack on Speech Recognition
Automatic Speech Recognition systems have been shown to be vulnerable to
adversarial attacks that manipulate the command executed on the device. Recent
research has focused on exploring methods to create such attacks, however, some
issues relating to Over-The-Air (OTA) attacks have not been properly addressed.
In our work, we examine the needed properties of robust attacks compatible with
the OTA model, and we design a method of generating attacks with arbitrary such
desired properties, namely the invariance to synchronization, and the
robustness to filtering: this allows a Denial-of-Service (DoS) attack against
ASR systems. We achieve these characteristics by constructing attacks in a
modified frequency domain through an inverse Fourier transform. We evaluate our
method on standard keyword classification tasks and analyze it in OTA, and we
analyze the properties of the cross-domain attacks to explain the efficiency of
the approach.Comment: 10 pages, 11 Figure
IR-QNN Framework: An IR Drop-Aware Offline Training Of Quantized Crossbar Arrays
Resistive Crossbar Arrays present an elegant implementation solution for Deep Neural Networks acceleration. The Matrix-Vector Multiplication, which is the corner-stone of DNNs, is carried out in O(1) compared to O(N-2) steps for digital realizations of O(log(2)(N)) steps for in-memory associative processors. However, the IR drop problem, caused by the inevitable interconnect wire resistance in RCAs remains a daunting challenge. In this article, we propose a fast and efficient training and validation framework to incorporate the wire resistance in Quantized DNNs, without the need for computationally extensive SPICE simulations during the training process. A fabricated four-bit Au/Al2O3/HfO2/TiN device is modelled and used within the framework with two-mapping schemes to realize the quantized weights. Efficient system-level IR-drop estimation methods are used to accelerate training. SPICE validation results show the effectiveness of the proposed method to capture the IR drop problem achieving the baseline accuracy with a 2% and 4% drop in the worst-case scenario for MNIST dataset on multilayer perceptron network and CIFAR 10 dataset on modified VGG and AlexNet networks, respectively. Other nonidealities, such as stuck-at fault defects, variability, and aging, are studied. Finally, the design considerations of the neuronal and the driver circuits are discussed
Hardware acceleration of DNA pattern matching using analog resistive CAMs
DNA pattern matching is essential for many widely used bioinformatics applications. Disease diagnosis is one of these applications since analyzing changes in DNA sequences can increase our understanding of possible genetic diseases. The remarkable growth in the size of DNA datasets has resulted in challenges in discovering DNA patterns efficiently in terms of run time and power consumption. In this paper, we propose an efficient pipelined hardware accelerator that determines the chance of the occurrence of repeat-expansion diseases using DNA pattern matching. The proposed design parallelizes the DNA pattern matching task using associative memory realized with analog content-addressable memory and implements an algorithm that returns the maximum number of consecutive occurrences of a specific pattern within a DNA sequence. We fully implement all the required hardware circuits with PTM 45-nm technology, and we evaluate the proposed architecture on a practical human DNA dataset. The results show that our design is energy-efficient and accelerates the DNA pattern matching task by more than 100× compared to the approaches described in the literature
Induction of antibacterial metabolites by co-cultivation of two Red-Sea-sponge-associated actinomycetes <i>Micromonospora</i> sp. UR56 and <i>Actinokinespora</i> sp. EG49
Liquid chromatography coupled with high resolution mass spectrometry (LC-HRESMS)-assisted metabolomic profiling of two sponge-associated actinomycetes, Micromonospora sp. UR56 and Actinokineospora sp. EG49, revealed that the co-culture of these two actinomycetes induced the accumulation of metabolites that were not traced in their axenic cultures. Dereplication suggested that phenazine-derived compounds were the main induced metabolites. Hence, following large-scale co-fermentation, the major induced metabolites were isolated and structurally characterized as the already known dimethyl phenazine-1,6-dicarboxylate (1), phenazine-1,6-dicarboxylic acid mono methyl ester (phencomycin; 2), phenazine-1-carboxylic acid (tubermycin; 3), N-(2-hydroxyphenyl)-acetamide (9), and p-anisamide (10). Subsequently, the antibacterial, antibiofilm, and cytotoxic properties of these metabolites (1–3, 9, and 10) were determined in vitro. All the tested compounds except 9 showed high to moderate antibacterial and antibiofilm activities, whereas their cytotoxic effects were modest. Testing against Staphylococcus DNA gyrase-B and pyruvate kinase as possible molecular targets together with binding mode studies showed that compounds 1–3 could exert their bacterial inhibitory activities through the inhibition of both enzymes. Moreover, their structural differences, particularly the substitution at C-1 and C-6, played a crucial role in the determination of their inhibitory spectra and potency. In conclusion, the present study highlighted that microbial co-cultivation is an efficient tool for the discovery of new antimicrobial candidates and indicated phenazines as potential lead compounds for further development as antibiotic scaffold
The genus <i>Micromonospora</i> as a model microorganism for bioactive natural product discovery
This review covers the development of the genus Micromonospora as a model for natural product research and the timeline of discovery progress from the classical bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target specific products. It focuses on the reported chemical structures along with their biological activities and the synthetic and biosynthetic studies they have inspired. This survey summarizes the extraordinary biosynthetic diversity that can emerge from a widely distributed actinomycete genus and supports future efforts to explore under-explored species in the search for novel natural products
- …