Multi-wavelength analysis of the Galactic supernova remnant MSH 11-61A

Due to its centrally bright X-ray morphology and limb brightened radio profile, MSH 11-61A (G290.1-0.8) is classified as a mixed morphology supernova remnant (SNR). H\textsc{i} and CO observations determined that the SNR is interacting with molecular clouds found toward the north and southwest regions of the remnant. In this paper we report on the detection of $\gamma$-ray emission coincident with MSH 11-61A, using 70 months of data from the Large Area Telescope on board the \textit{Fermi Gamma-ray Space Telescope}. To investigate the origin of this emission, we perform broadband modelling of its non-thermal emission considering both leptonic and hadronic cases and concluding that the $\gamma$-ray emission is most likely hadronic in nature. Additionally we present our analysis of a 111 ks archival \textit{Suzaku} observation of this remnant. Our investigation shows that the X-ray emission from MSH 11-61A arises from shock-heated ejecta with the bulk of the X-ray emission arising from a recombining plasma, while the emission towards the east arises from an ionising plasma.Comment: 12 Pages, 8 figures. Accepted for publication in the Astrophysical Journa

Super Tall Timber: design research for the next generation of natural structure

This research project aspires to make truly tall timber buildings a reality. Through a combination of theoretical design and physical testing this research demonstrates the viability of timber buildings at much greater heights than has previously been possible. By pushing the limits of theoretical designs into the realms of the supertall, sometimes beyond that which is feasible using current materials and construction technologies, this research also sets out the requirements for the next generation of engineered plant-based materials. The research is a collaboration between academics, practicing architects and practicing structural engineers. The approach is research through design, and design through research. Timber towers are designed well beyond exist ing heights, and analysed to understand how they stand up and which areas are most critical for further research. By bringing highly regarded architectural and structural designers together with the research capabilities of a leading university, this project creates a precedent-setting model for interdisciplinary engagement within and between the design and research communities. By coupling exemplary design in timber a university’s research capacity, the project represents a real opportunity for transform ational change in the design of tall timber buildings. Essential details and connections are determined and ‘unknowns’ with respect to material and structural performance are identified. A programme of testing to investigate these unknowns and validate the design approaches is carried out at the university. Outcomes of the test programme and new insights are fed back into the design process. The results show that tall timber towers are feasible, with substantial but surmountable questions outstanding. By providing thought provoking yet credible solutions for the design of tall timber buildings and exceeding current limits, the project can inspire the design community to think beyond the status quo and embrace the possibilities offered by timber construction.The work forms part of a research study conceived and led by Cambridge University with input from PLP Architecture and Smith and Wallwork Engineers. Funding for this research is in part provided by the EPSRC under grant EP/M01679X/1

The consequences of replicating in the wrong orientation: Bacterial chromosome duplication without an active replication origin

Chromosome replication is regulated in all organisms at the assembly stage of the replication machinery at specific origins. In Escherichia coli the DnaA initiator protein regulates the assembly of replication forks at oriC. This regulation can be undermined by defects in nucleic acid meta¬bolism. In cells lacking RNase HI replication initiates indepen¬dently of DnaA and oriC, presumably at persisting R-loops. A similar mechanism was assumed for origin-independent synthesis in cells lacking RecG. However, recently we suggested that this synthesis initiates at intermediates resulting from replication fork fusions. Here we present data suggesting that in cells lacking RecG or RNase HI origin-independent synthesis arises by different mechanisms, indicative of these two proteins having different roles in vivo. Our data support the idea that RNase HI processes R-loops, while RecG is required to process replication fork fusion intermediates. However, regardless of how origin-independent synthesis is initiated, a fraction of forks will proceed in an orientation opposite to normal. We show that the resulting head-on encounters with transcription threaten cell viability, especially if taking place in highly-transcribed areas. Thus, despite their different functions, RecG and RNase HI are both important factors for maintaining replication control and orientation. Their absence causes severe replication problems, highlighting the advantages of the normal chromosome arrangement, which exploits a single origin to control the number of forks and their orientation relative to transcription, and a defined termination area to contain fork fusions. Any changes to this arrangement endanger cell cycle control, chromosome dynamics and, ultimately, cell viability.This work was supported by the Royal Society (RG110414 to C.J.R.) and The Biotechnology and Biological Sciences Research Council (BB/K015729/1 to C.J.R.)

A cohort study of the recovery of health and wellbeing following colorectal cancer (CREW study): protocol paper

Background: the number of people surviving colorectal cancer has doubled in recent years. While much of the literature suggests that most people return to near pre-diagnosis status following surgery for colorectal cancer, this literature has largely focused on physical side effects. Longitudinal studies in colorectal cancer have either been small scale or taken a narrow focus on recovery after surgery. There is a need for a comprehensive, long-term study exploring all aspects of health and wellbeing in colorectal cancer patients. The aim of this study is to establish the natural history of health and wellbeing in people who have been treated for colorectal cancer. People have different dispositions, supports and resources, likely resulting in individual differences in restoration of health and wellbeing. The protocol described in this paper is of a study which will identify who is most at risk of problems, assess how quickly people return to a state of subjective health and wellbeing, and will measure factors which influence the course of recovery. Methods: this is a prospective, longitudinal cohort study following 1000 people with colorectal cancer over a period of two years, recruiting from 30 NHS cancer treatment centres across the UK. Questionnaires will be administered prior to surgery, and 3, 9, 15 and 24 months after surgery, with the potential to return to this cohort to explore on-going issues related to recovery after cancer. Discussion: outcomes will help inform health care providers about what helps or hinders rapid and effective recovery from cancer, and identify areas for intervention development to aid this process. Once established the cohort can be followed up for longer periods and be approached to participate in related projects as appropriate and subject to funding<br/