Oedipus and the Stars

At OT 795 Oedipus’ recollection of measuring his fugitive course by the stars presents a double crux, concerning both the textual tradition’s dueling terms for that measurement and scholars’ related, opposed renderings of the phrase as literal or figurative. I argue Oedipus’ words can be taken literally to signify the techne of ancient celestial navigation, a metric of human knowhow versus the forces of fate and the divine

Modified Aminoglycosides Bind Nucleic Acids in High-Molecular-Weight Complexes

Aminoglycosides represent a large group of antibiotics well known for their ability to target the bacterial ribosome. In studying 6”-substituted variants of the aminoglycoside tobramycin, we serendipitously found that compounds with C12 or C14 linear alkyl substituents potently inhibit reverse transcription in vitro. Initial observations suggested specific inhibition of reverse transcriptase. However, further analysis showed that these and related compounds bind nucleic acids with high affinity, forming high-molecular weight complexes. Stable complex formation is observed with DNA or RNA in single- or double-stranded form. Given the amphiphilic nature of these aminoglycoside derivatives, they likely form micelles and/or vesicles with surface-bound nucleic acids. Hence, these compounds may be useful tools to localize nucleic acids to surfaces or deliver nucleic acids to cells or organelles