"A Decentralized Operations Concept for the European Payloads on the International Space Station"

The European Module Columbus of the International Space Station (ISS) is planned to be launched 2004. For its exploitation phase as well as for the early utilisation of the Space Station starting from 2003 onwards the operations procedures are now being defined in detail and the implementation of specific infrastructure has started. A decentralised operations concept will allow the investigators to perform their experiments using the telescience technique of remote experiment operations whenever feasible. User Support and Operation Centres (USOCs) will act as Facility Responsible Centres (FRC) performing the operations for multi user experiment facilities. The Columbus Control Centre (COL-CC) will perform the Columbus system operations, co-ordinate the European payload operations and provide the European Communications network. This paper gives an overview on the operations concepts and the tasks and set up of the involved sites

The ALTCRISS project on board the International Space Station

The Altcriss project aims to perform a long term survey of the radiation environment on board the International Space Station. Measurements are being performed with active and passive devices in different locations and orientations of the Russian segment of the station. The goal is to perform a detailed evaluation of the differences in particle fluence and nuclear composition due to different shielding material and attitude of the station. The Sileye-3/Alteino detector is used to identify nuclei up to Iron in the energy range above 60 MeV/n. Several passive dosimeters (TLDs, CR39) are also placed in the same location of Sileye-3 detector. Polyethylene shielding is periodically interposed in front of the detectors to evaluate the effectiveness of shielding on the nuclear component of the cosmic radiation. The project was submitted to ESA in reply to the AO in the Life and Physical Science of 2004 and data taking began in December 2005. Dosimeters and data cards are rotated every six months: up to now three launches of dosimeters and data cards have been performed and have been returned with the end of expedition 12 and 13.Comment: Accepted for publication on Advances in Space Research http://dx.doi.org/10.1016/j.asr.2007.04.03

Economic consequences of investing in anti-HCV antiviral treatment from the Italian NHS perspective : a real-world-based analysis of PITER data

OBJECTIVE: We estimated the cost consequence of Italian National Health System (NHS) investment in direct-acting antiviral (DAA) therapy according to hepatitis C virus (HCV) treatment access policies in Italy. METHODS: A multistate, 20-year time horizon Markov model of HCV liver disease progression was developed. Fibrosis stage, age and genotype distributions were derived from the Italian Platform for the Study of Viral Hepatitis Therapies (PITER) cohort. The treatment efficacy, disease progression probabilities and direct costs in each health state were obtained from the literature. The break-even point in time (BPT) was defined as the period of time required for the cumulative costs saved to recover the Italian NHS investment in DAA treatment. Three different PITER enrolment periods, which covered the full DAA access evolution in Italy, were considered. RESULTS: The disease stages of 2657 patients who consecutively underwent DAA therapy from January 2015 to December 2017 at 30 PITER clinical centres were standardized for 1000 patients. The investment in DAAs was considered to equal €25 million, €15 million, and €9 million in 2015, 2016, and 2017, respectively. For patients treated in 2015, the BPT was not achieved, because of the disease severity of the treated patients and high DAA prices. For 2016 and 2017, the estimated BPTs were 6.6 and 6.2 years, respectively. The total cost savings after 20 years were €50.13 and €55.50 million for 1000 patients treated in 2016 and 2017, respectively. CONCLUSIONS: This study may be a useful tool for public decision makers to understand how HCV clinical and epidemiological profiles influence the economic burden of HCV

L'Italia come modello per l'Europa e per il mondo nelle politiche sanitarie per il trattamento dell'epatite cronica da HCV

The World Health Organization foresees the elimination of HCV infection by 2030. In light of this and the curre nt, nearly worldwide, restriction in direct-acting agents (DAA) accessibility due to their high price, we aimed to evaluate the cost-effectiveness of two alternative DAA treatment policies: Policy 1 (universal): treat all patients, regardless of the fibrosis stage; Policy 2 (prioritized): treat only priori tized patients and delay treatment of the remaining patients until reaching stage F3. T he model was based on patient’s data from the PITER cohort. We demonstrated that extending HC V treatment of patients in any fibrosis stage improves health outcomes and is cost-effective

Flight results on Marangoni flow instability in liquid bridges

This paper reports on the results of the experiment PULSAR (Pulsating and Rotating Instabilities in Oscillatory Marangoni Flows), performed on the MAXUS 3 Sounding Rocket launched last November from the Swedish base in Kiruna. Aim of the experiment was the study of the oscillatory Marangoni convection in a cylindrical liquid bridge of silicone oil with kinematic viscosity of 5cSt. The experiment was motivated by preliminary on-ground numerical simulations and microscale experimental studies, that have pointed out that the oscillatory Marangoni instability appears at the beginning in the form of a pulsating regime, caused by a hydro-thermal standing wave, and then it turns to a rotating regime, caused by a traveling wave. The height of the bridge was equal to the disk diameter (20mm), and the imposed temperature difference was 15K during the first 460 s and 20K in the second part of the experiment, until the end of the microgravity period. The analysis of the temperature profiles, measured by thermocouples located near the disks at the same radial and axial coordinate but at different azimuthal coordinates (shifted at 90°), and the surface temperature distribution, measured by an infrared thermocamera, show that a pulsating and a mixed pulsating-rotating regimes have been established during the experiment. Unfortunately during the flight the accelerations level caused by two centrifuges with some biological samples in an adjacent module were above the expected values, so that disturbing g-jitter were encountered at different times during the microgravity mission. The effecst are clearly visible and the numerical simulations had to make different assumptions to correlate the experimental results

Il ruolo del marketing nelle strategie di riconfigurazione del business: il caso DR

Il paper si focalizza sul ruolo del marketing nei processi di riconfigurazione del business, prendendo in riferimento il caso di una PMI molisana (DR Motor Company), che è passata progressivamente dalla semplice distribuzione alla produzione di automobili, in un contesto competitivo e settoriale caratterizzato da elevata complessità. Il lavoro mira ad indagare le seguenti problematiche di ricerca: • quali possono essere le modalità concrete di riconfigurazione di un business, nella fattispecie in un settore maturo; • qual è il ruolo e il campo d’azione del marketing in strategie di questo tipo; • in quale modo logiche manageriali creative possono declinarsi, da un lato, su un piano strategico e, dall’altro, su un piano operativo