The Effects of Lesions in the Dorsolateral Pons on the Coordination of Swallowing and Breathing in Awake Goats

The purpose of this retrospective study was to gain insight into the contribution of the dorsolateral pons to the coordination of swallowing and breathing in awake goats. In 4 goats, cannulas were chronically implanted bilaterally through the lateral (LPBN) and medial (MPBN) parabrachial nuclei just dorsal to the Kölliker–Fuse nucleus (KFN). After \u3e2 weeks recovery from this surgery, the goats were studied for 5½ h on a control day, and on separate days after receiving 1 and 10 μl injections of ibotenic acid (IA) separated by 1 week. The frequency of swallows did not change during the control and 1 μl IA studies, but after injection of 10 μl IA, there was a transient 65% increase in frequency of swallows (P \u3c 0.05). Under control conditions swallows occurred throughout the respiratory cycle, where late-E swallows accounted for 67.6% of swallows. The distribution of swallow occurrence throughout the respiratory cycle was unaffected by IA injections. Consistent with the concept that swallowing is dominant over breathing, we found that swallows increased inspiratory (TI) and expiratory (TE) time and decreased tidal volume (VT) of the breath of the swallow (n) and/or the subsequent (n + 1) breath. Injections of 10 μl IA attenuated the normal increases in TI and TE and further attenuated VT of the n breath. Additionally, E and I swallows reset respiratory rhythm, but injection of 1 or 10 μl IA progressively attenuated this resetting, suggesting a decreased dominance over respiratory motor output with increasing IA injections. Post mortem histological analysis revealed about 50% fewer (P \u3c 0.05) neurons remained in the KFN, LPBN, and MPBN in lesioned compared to control goats. We conclude that dorsolateral pontine nuclei have a modulatory role in a hypothesized holarchical neural network regulating swallowing and breathing particularly contributing to the normal dominance of swallowing over breathing in both rhythm and motor pattern generation

Polarization fluctuations in insulators and metals: New and old theories merge

The ground-state fluctuation of polarization P is finite in insulators and divergent in metals, owing to the SWM sum rule [I. Souza, T. Wilkens, and R. M. Martin, Phys. Rev. B 62, 1666 (2000)]. This is a virtue of periodic (i.e. transverse) BCs. I show that within any other boundary conditions the P fluctuation is finite even in metals, and a generalized sum rule applies. The boundary-condition dependence is a pure correlation effect, not present at the independent-particle level. In the longitudinal case div P = -rho, and one equivalently addresses charge fluctuations: the generalized sum rule reduces then to a well known result of many-body theory.Comment: 4 pages, no figur

Nonlinearities in Conservative Growth Equations

Using the dynamic renormalization group (DRG) technique, we analyze general nonlinearities in a conservative nonlinear growth equation with non-conserved gaussian white noise. We show that they fall in two classes only: the Edwards-Wilkinson and Lai-Das Sarma types, by explicitly computing the associated amputated two and three point functions at the first order in perturbation parameter(s). We further generalize this analysis to higher order nonlinearities and also suggest a physically meaningful geometric interpretation of the same.Comment: REVTEX, will appear in Phys Rev E Rapid Comm. February 1996, .ps figure file available upon request to [email protected]

Asymmetric Thermal Lineshape Broadening in a Gapped 3-Dimensional Antiferromagnet - Evidence for Strong Correlations at Finite Temperature

It is widely believed that magnetic excitations become increasingly incoherent as temperature is raised due to random collisions which limit their lifetime. This picture is based on spin-wave calculations for gapless magnets in 2 and 3 dimensions and is observed experimentally as a symmetric Lorentzian broadening in energy. Here, we investigate a three-dimensional dimer antiferromagnet and find unexpectedly that the broadening is asymmetric - indicating that far from thermal decoherence, the excitations behave collectively like a strongly correlated gas. This result suggests that a temperature activated coherent state of quasi-particles is not confined to special cases like the highly dimerized spin-1/2 chain but is found generally in dimerized antiferromagnets of all dimensionalities and perhaps gapped magnets in general

Distributed Edge Connectivity in Sublinear Time

We present the first sublinear-time algorithm for a distributed message-passing network sto compute its edge connectivity $\lambda$ exactly in the CONGEST model, as long as there are no parallel edges. Our algorithm takes $\tilde O(n^{1-1/353}D^{1/353}+n^{1-1/706})$ time to compute $\lambda$ and a cut of cardinality $\lambda$ with high probability, where $n$ and $D$ are the number of nodes and the diameter of the network, respectively, and $\tilde O$ hides polylogarithmic factors. This running time is sublinear in $n$ (i.e. $\tilde O(n^{1-\epsilon})$) whenever $D$ is. Previous sublinear-time distributed algorithms can solve this problem either (i) exactly only when $\lambda=O(n^{1/8-\epsilon})$ [Thurimella PODC'95; Pritchard, Thurimella, ACM Trans. Algorithms'11; Nanongkai, Su, DISC'14] or (ii) approximately [Ghaffari, Kuhn, DISC'13; Nanongkai, Su, DISC'14]. To achieve this we develop and combine several new techniques. First, we design the first distributed algorithm that can compute a $k$-edge connectivity certificate for any $k=O(n^{1-\epsilon})$ in time $\tilde O(\sqrt{nk}+D)$. Second, we show that by combining the recent distributed expander decomposition technique of [Chang, Pettie, Zhang, SODA'19] with techniques from the sequential deterministic edge connectivity algorithm of [Kawarabayashi, Thorup, STOC'15], we can decompose the network into a sublinear number of clusters with small average diameter and without any mincut separating a cluster (except the `trivial' ones). Finally, by extending the tree packing technique from [Karger STOC'96], we can find the minimum cut in time proportional to the number of components. As a byproduct of this technique, we obtain an $\tilde O(n)$-time algorithm for computing exact minimum cut for weighted graphs.Comment: Accepted at 51st ACM Symposium on Theory of Computing (STOC 2019

Mid-Infrared Imaging of NGC 6334 I

We present high-resolution (<0.5") mid-infrared Keck II images of individual sources in the central region of NGC 6334 I. We compare these images to images at a variety of other wavelengths from the near infrared to cm radio continuum and speculate on the nature of the NGC 6334 I sources. We assert that the cometary shape of the UCHII region here, NGC 6334 F, is due to a champagne-like flow from a source on the edge of a molecular clump and not a due to a bow shock caused by the supersonic motion of the UCHII region through the interstellar medium. The mid-infrared emission in concentrated into an arc of dust that define the boundary between the UCHII region and the molecular clump. This dust arc contains a majority of the masers in the region. We discuss the nature of the four near-infrared sources associated with IRS-I 1, and suggest that one of the sources, IRS1E, is responsible for the heating and ionizing of the UCHII region and the mid-infrared dust arc. Infrared source IRS-I 2, which has been thought to be a circumstellar disk associated with a linear distribution of methanol masers, is found not to be directly coincident with the masers and elongated at a much different position angle. IRS-I 3 is found to be a extended source of mid-infrared emission coming from a cluster of young dusty sources seen in the near-infrared.Comment: Accepted for publication by the Astrophysical Journal, 27 pages, 9 figure

A New Method of Measuring 81Kr and 85Kr Abundances in Environmental Samples

We demonstrate a new method for determining the 81Kr/Kr ratio in environmental samples based upon two measurements: the 85Kr/81Kr ratio measured by Atom Trap Trace Analysis (ATTA) and the 85Kr/Kr ratio measured by Low-Level Counting (LLC). This method can be used to determine the mean residence time of groundwater in the range of 10^5 - 10^6 a. It requires a sample of 100 micro-l STP of Kr extracted from approximately two tons of water. With modern atmospheric Kr samples, we demonstrate that the ratios measured by ATTA and LLC are directly proportional to each other within the measurement error of +/- 10%; we calibrate the 81Kr/Kr ratio of modern air measured using this method; and we show that the 81Kr/Kr ratios of samples extracted from air before and after the development of the nuclear industry are identical within the measurement error

Patritumab or Placebo Plus Cetuximab and Platinum-Based Therapy in Squamous Cell Carcinoma of the Head and Neck (SCCHN): a Phase 2 Study

BACKGROUND: P is a fully human monoclonal antibody against human epidermal growth factor receptor 3. P blocks activation by the ligand, heregulin (HRG), inducing receptor internalization. Evidence is growing that HRG presence determines disease progression and survival; in a phase 2 study in non–small-cell lung cancer, P + erlotinib increased progression-free survival (PFS) in high HRG mRNA expression (HRG-high) patients. A phase 1b study in SCCHN demonstrated safety, tolerability and tumor response of P + C + cisplatin or carboplatin and informed the P phase 2 dose. January 2016 (N = 15) response rate = 47%; best responses = 3 complete response (CR), 4 partial response (PR) and 8 stable disease (SD). This phase 2 study (NCT02633800) evaluates first-line P + C + platinum (P arm) vs. PBO + C + platinum (PBO arm) in recurrent and/or metastatic (R/M) SCCHN. The primary objective is to evaluate PFS in the HRG-high population (P vs. PBO arms). METHODS: This is arandomized, controlled, double-blind first-line study in Europe. Patients aged ≥ 18 years with confirmed R/M SCCHN, ECOG performance status ≤ 1 and documented HRG expression (per archived or fresh biopsies) are eligible. The primary efficacy endpoint is PFS. Secondary endpoints include overall survival, overall response rate, pharmacokinetics and safety (including human antihuman antibody incidence). Approximately 105 patients will be stratified 2:1 by HRG status (70 high; 35 low), and then randomized 1:1 to the P or PBO arm. All patients will receive either intravenous P (18mg/kg loading dose [LD]; 9mg/kg maintenance dose [MD] every 3 weeks [q3w]) or PBO, and C (400mg/m2 LD; 250mg/m2 MD weekly) + ≤ 6 cycles of cisplatin (100mg/m2 q3w) or carboplatin (area under the curve of 5). Patients demonstrating CR, PR or SD will be treated with P/PBO + C + ≤ 6 cycles platinum for the study duration (until all patients have died or ≥ 13 months postrandomization of last patient); those benefiting may continue treatment uninterrupted in an open-label extension phase until progressive disease, toxicity or withdrawal. Survival status will be obtained ≥ 13 months after discontinuation. The first patient was dosed December 2015 and enrollment is open. Clinical trial information: NCT0263380