Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay

Background: Congenital forms of hearing impairment can be caused by mutations in the estrogen related receptor beta (ESRRB) gene. Our initial linkage studies suggested the ESRRB locus is linked to high caries experience in humans.Methods: We tested for association between the ESRRB locus and dental caries in 1,731 subjects, if ESRRB was expressed in whole saliva, if ESRRB was associated with the microhardness of the dental enamel, and if ESRRB was expressed during enamel development of mice.Results: Two families with recessive ESRRB mutations and DFNB35 hearing impairment showed more extensive dental destruction by caries. Expression levels of ESRRB in whole saliva samples showed differences depending on sex and dental caries experience.Conclusions: The common etiology of dental caries and hearing impairment provides a venue to assist in the identification of individuals at risk to either condition and provides options for the development of new caries prevention strategies, if the associated ESRRB genetic variants are correlated with efficacy. © 2014 Weber et al.; licensee BioMed Central Ltd

Space Qualified Magnetic Disk

International Telemetering Conference Proceedings / October 25-28, 1993 / Riviera Hotel and Convention Center, Las Vegas, NevadaHighly reliable data storage for satellites and spacecraft is a challenging technology. The space environment is a unique combination of many environmental factors which impact the reliability and even the very survival of electronic systems. The need for space qualified memory is becoming even more important with the advent of on-board data processing which requires rapid access to large data bases. This paper describes the unique environmental and design considerations that must be taken into account for a magnetic disk that is designed to operate for years in the space environment.International Foundation for TelemeteringProceedings from the International Telemetering Conference are made available by the International Foundation for Telemetering and the University of Arizona Libraries. Visit http://www.telemetry.org/index.php/contact-us if you have questions about items in this collection

Space qualified magnetic disk

International Telemetering Conference Proceedings / October 25-28, 1993 / Riviera Hotel and Convention Center, Las Vegas, NevadaHighly reliable data storage for satellites and spacecraft is a challenging technology. The space environment is a unique combination of many environmental factors which impact the reliability and even the very survival of electronic systems. The need for space qualified memory is becoming even more important with the advent of on-board data processing which requires rapid access to large data bases. This paper describes the unique environmental and design considerations that must be taken into account for a magnetic disk that is designed to operate for years in the space environment.International Foundation for TelemeteringProceedings from the International Telemetering Conference are made available by the International Foundation for Telemetering and the University of Arizona Libraries. Visit http://www.telemetry.org/index.php/contact-us if you have questions about items in this collection