Twilight for the energy conditions?

The tension, if not outright inconsistency, between quantum physics and general relativity is one of the great problems facing physics at the turn of the millennium. Most often, the problems arising in merging Einstein gravity and quantum physics are viewed as Planck scale issues (10^{19} GeV, 10^{-34} m, 10^{-45} s), and so safely beyond the reach of experiment. However, over the last few years it has become increasingly obvious that the difficulties are more widespread: There are already serious problems of deep and fundamental principle at the semi-classical level, and worse, certain classical systems (inspired by quantum physics, but in no sense quantum themselves) exhibit seriously pathological behaviour. One manifestation of these pathologies is in the so-called ``energy conditions'' of general relativity. Patching things up in the gravity sector opens gaping holes elsewhere; and some ``fixes'' are more radical than the problems they are supposed to cure.Comment: Honourable mention in the 2002 Gravity Research Foundation essay contest. 12 pages. Plain LaTeX 2

Effectiveness of highly active antiretroviral therapy in HIV-positive children: evaluation at 12 months in a routine program in Cambodia.

OBJECTIVE: Increasing access to highly active antiretroviral therapy to reach all those in need in developing countries (scale up) is slowly expanding to HIV-positive children, but documented experience remains limited. We aimed to describe the clinical, immunologic, and virologic outcomes of pediatric patients with >12 months of highly active antiretroviral therapy in 2 routine programs in Cambodia. METHODS: Between June 2003 and March 2005, 212 children who were younger than 13 years started highly active antiretroviral therapy. Most patients started a standard first-line regimen of lamivudine, stavudine, and nevirapine, using split adult fixed-dosage combinations. CD4 percentage and body weight were monitored routinely. A cross-sectional virologic analysis was conducted in January 2006; genotype resistance testing was performed for patients with a detectable viral load. RESULTS: Mean age of the subjects was 6 years. Median CD4 percentage at baseline was 6. Survival was 92% at 12 months and 91% at 24 months; 13 patients died, and 4 were lost to follow-up. A total of 81% of all patients had an undetectable viral load. Among the patients with a detectable viral load, most mutations were associated with resistance to lamivudine and non-nucleoside reverse-transcriptase inhibitor drugs. Five patients had developed extensive antiretroviral resistance. Being an orphan was found to be a predictor of virologic failure. CONCLUSIONS: This study provides additional evidence of the effectiveness of integrating HIV/AIDS care with highly active antiretroviral therapy for children in a routine setting, with good virologic suppression and immunologic recovery achieved by using split adult fixed-dosage combinations. Viral load monitoring and HIV genotyping are valuable tools for the clinical follow-up of the patients. Orphans should receive careful follow-up and extra support

Debris and micrometeorite impact measurements in the laboratory

A method was developed to simulate space debris in the laboratory. This method, which is an outgrowth of research in inertial confinement fusion (ICF), uses laser ablation to accelerate material. Using this method, single 60 micron aluminum spheres were accelerated to 15 km/sec and larger 500 micron aluminum spheres were accelerated to 2 km/sec. Also, many small (less than 10 micron diameter) irregularly shaped particles were accelerated to speeds of 100 km/sec

Controlling transition probability from matter-wave soliton to chaos

For a Bose-Einstein condensate loaded into a weak traveling optical superlattice it is demonstrated that under a stochastic initial set and in a given parameter region the solitonic chaos appears with a certain probability. Effects of the lattice depths and wave vectors on the chaos probability are investigated analytically and numerically, and different chaotic regions associated with different chaos probabilities are found. The results suggest a feasible method for eliminating or strengthening chaos by modulating the moving superlattice experimentally.Comment: 4 pages, 2 figure

Electron focusing, mode spectroscopy and mass enhancement in small GaAs/AlGaAs rings

A new electron focusing effect has been discovered in small single and coupled GaAs/AlGaAs rings. The focusing in the single ring is attributed solely to internal orbits. The focusing effect allows the ring to be used as a small mass spectrometer. The focusing causes peaks in the magnetoresistance at low fields, and the peak positions were used to study the dispersion relation of the one-dimensional magnetoelectric subbands. The electron effective mass increases with the applied magnetic field by a factor of $50$, at a magnetic field of $0.5T$. This is the first time this increase has been measured directly. General agreement obtains between the experiment and the subband calculations for straight channels.Comment: 13 pages figures are available by reques

The Energy Density in the Casimir Effect

We compute the expectations of the squares of the electric and magnetic fields in the vacuum region outside a half-space filled with a uniform dispersive dielectric. We find a positive energy density of the electromagnetic field which diverges at the interface despite the inclusion of dispersion in the calculation. We also investigate the mean squared fields and the energy density in the vacuum region between two parallel half-spaces. Of particular interest is the sign of the energy density. We find that the energy density is described by two terms: a negative position independent (Casimir) term, and a positive position dependent term with a minimum value at the center of the vacuum region. We argue that in some cases, including physically realizable ones, the negative term can dominate in a given region between the two half-spaces, so the overall energy density can be negative in this region.Comment: 16 pages, 4 figures; 3 references and some new material in Sect. 4.4 adde

Quantum Inequalities and Singular Energy Densities

There has been much recent work on quantum inequalities to constrain negative energy. These are uncertainty principle-type restrictions on the magnitude and duration of negative energy densities or fluxes. We consider several examples of apparent failures of the quantum inequalities, which involve passage of an observer through regions where the negative energy density becomes singular. We argue that this type of situation requires one to formulate quantum inequalities using sampling functions with compact support. We discuss such inequalities, and argue that they remain valid even in the presence of singular energy densities.Comment: 18 pages, LaTex, 2 figures, uses eps

Advancing methodology for scoping reviews: recommendations arising from a scoping literature review (SLR) to inform transformation of Children and Adolescent Mental Health Services

Background There is consensus that health services commissioning and clinical practice should be driven by scientific evidence. However, workload pressures, accessibility of peer reviewed publications and skills to find, appraise, and synthesise relevant evidence are often cited as barriers to uptake of research evidence by practitioners and commissioners alike. In recent years a growing requirement for rapid evidence synthesis to inform commissioning decisions about healthcare service delivery and provision of care contributed to an increasing popularity of scoping literature reviews (SLRs). Yet, comprehensive guidelines for conducting and reporting SLRs are still relatively scarce. Methods The exemplar review used as a worked example aimed to provide a readily available, comprehensive, and user-friendly repository of research evidence for local commissioners to help them make evidence-informed decisions about redesigning East of England Children and Adolescent Mental Health Services. In conducting the review, we were broadly guided by Arksey and O’Malley’s framework, however some modifications were made at different stages to better reflect the largely pragmatic objective of this review. This paper compares the methodology used with existing methodological frameworks for scoping studies, to add to the existing knowledge base. Results We proposed the following advancements to the existing SLR frameworks: (i) Assemble a research team with complementary skills and expertise; (ii); Draw on expertise of external partners, particularly practitioners, decision-makers and commissioners who will be translating findings into practice; (iii) Pre-register the review protocol. Keep a detailed record of all steps and decisions and consider how they would impact on generalisability and utility of review findings; (iv) Use systematic procedures for literature searchers, selection of studies, data extraction and analysis; (v) If feasible, appraise the quality of included evidence; (vi) Be transparent about limitations of findings. Conclusions Despite some methodological limitations, scoping literature reviews are a useful method of rapidly synthesising a large body of evidence to inform commissioning and transformation of CAMHS. SLRs allow researchers to start with a broader questions, to explore the issue from different perspectives and perhaps find more comprehensive solutions that are not only effective, but also accounted for their feasibility and acceptability to key stakeholders