9 research outputs found
Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing
Get PDFRegulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance
Full text linkPharmacokinetics of a new microemulsion formulation of cyclosporin A (Neoral) in young patients after renal transplantation
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Characterisation of protein families in spider digestive fluids and their role in extra-oral digestion
No full textTesticular Steroidogenesis
No full textTestosterone is the major androgen in circulation in male humans, produced primarily in the Leydig cells of the testis. Biosynthesis of testosterone from cholesteroloccursviaaseriesofenzymaticreactions.Testosteronemaybefurther metabolized into a more potent androgen, dihydrotestosterone. In recent years an alternate pathway of dihydrotestosterone biosynthesis without using testosterone as a precursor has emerged. Majority of classically studied effects of androgens are thought to be mediated via nuclear receptor-dependent long-term transcriptional effects, but there also exist membrane receptor-based effects of androgens which are being uncovered from recent studies that may explain rapid effects of androgens in many cases. In this chapter we are describing the biosynthesis, mechanism of action, and therapeutic effects of testosterone and related androgens
