Flexible Automatic Scheduling For Autonomous Telescopes: The MAJORDOME

We have developped a new method for the scheduling of astronomical automatic telescopes, in the framework of the autonomous TAROT instrument. The MAJORDOME software can handle a variety of observations, constrained, periodic, etc., and produces a timeline for the night, which may be modified at any time to take into account the specific conditions of the night. The MAJORDOME can also handle target of opportunity observations without delay.Comment: 16 pages, 6 figures, to appear in Experimental Astronom

Adaptive Transmission Techniques for Mobile Satellite Links

Adapting the transmission rate in an LMS channel is a challenging task because of the relatively fast time variations, of the long delays involved, and of the difficulty in mapping the parameters of a time-varying channel into communication performance. In this paper, we propose two strategies for dealing with these impairments, namely, multi-layer coding (MLC) in the forward link, and open-loop adaptation in the return link. Both strategies rely on physical-layer abstraction tools for predicting the link performance. We will show that, in both cases, it is possible to increase the average spectral efficiency while at the same time keeping the outage probability under a given threshold. To do so, the forward link strategy will rely on introducing some latency in the data stream by using retransmissions. The return link, on the other hand, will rely on a statistical characterization of a physical-layer abstraction measure.Comment: Presented at the 30th AIAA International Communications Satellite Systems Conference (ICSSC), Ottawa, Canada, 2012. Best Professional Paper Awar

Epsilon production in a geometrical approach

In a previous paper ε production was studied, by making used of dual properties, and it was qualitatively shown that pion exchange dominates near the forward direction and there is a small exchange with the A₁ quantum numbers. This is confirmed by the polarization data, since it clearly shows that two independent amplitudes are essential in this reaction. Duality also provides a guidance for the position of the zeros of the imaginary parts of these amphtudes. In this note we shall take over this problem again and quantitatively show that the dual predictions are in agreement with the experimental data.Facultad de Ciencias Exacta

Epsilon production in a geometrical approach

In a previous paper ε production was studied, by making used of dual properties, and it was qualitatively shown that pion exchange dominates near the forward direction and there is a small exchange with the A₁ quantum numbers. This is confirmed by the polarization data, since it clearly shows that two independent amplitudes are essential in this reaction. Duality also provides a guidance for the position of the zeros of the imaginary parts of these amphtudes. In this note we shall take over this problem again and quantitatively show that the dual predictions are in agreement with the experimental data.Facultad de Ciencias Exacta

Manipulation of drugs to achieve the required dose is intrinsic to paediatric practice but is not supported by guidelines or evidence

Background: A lack of age-appropriate formulations can make it difficult to administer medicines to children. A manipulation of the dosage form may be required to achieve the required dose. This study aimed to describe medicines that are manipulated to achieve the required dose in paediatric practice.Method: A structured, undisguised observational study and postal survey. The observational study investigated drug manipulations occurring in clinical practice across three sites. The questionnaire, administered to a sample of paediatric nurses throughout the UK, surveyed manipulations conducted and nurses' experiences and views.Results: The observational study identified 310 manipulations, of which 62% involved tablets, 21% were intravenous drugs and 10% were sachets. Of the 54 observed manipulations 40 involved tablets with 65% of the tablets being cut and 30% dispersed to obtain a smaller dose. 188 manipulations were reported by questionnaire respondents, of these 46% involved tablets, 12% were intravenous drugs, and 12% were nebuliser solutions. Manipulations were predominantly, but not exclusively, identified in specialist clinical areas with more highly dependent patients. Questionnaire respondents were concerned about the accuracy of the dose achieved following manipulations and the lack of practice guidance.Conclusion: Manipulations to achieve the required dose occur throughout paediatric in-patient settings. The impact of manipulations on the efficacy of the drugs, the accuracy of the dose and any adverse effects on patients is not known. There is a need to develop evidence-based guidance for manipulations of medicines in children

Morphodynamic response of open and embayed beaches to winter conditions: two case studies from the North Atlantic Iberian coast

The morphological responses of two mesotidal beaches located in different coastal settings (embayed and open sandy beaches) on the northwestern Iberian coast were monitored during the winter of 2018/19. The offshore wave time series analysis is related to high-resolution topo-bathymetric measurements to explore spatial-temporal morphological variability at monthly to seasonal scales. Both locations are subjected to the North Atlantic wave climate which exhibits a pronounced seasonality. Throughout the last decade (2010–2020), significant wave heights reached values of up to Hs~9 m during winters and up to Hs~6 m during summers. On average, approximately 12 storms occurred annually in this region. The results clearly reveal divergent morphological responses and sediment transport behaviors at the upper beach and the intertidal zone during the winter for each location. In the embayed beach (Patos), sediment transport in the nearshore is governed by cross-shore processes between the beach berm and a submerged sandbar. In contrast, the open beach (Mira) showed dynamic sediment exchanges and three-dimensional morphologies alternating between accumulation and erosion zones. Overall, both beaches exhibited an erosional trend after the winter, particularly concerning berm erosion and the subaerial beach volume/shoreline retreat. This study highlights the contrasting morphodynamic response on open and embayed beaches to winter conditions, integrating both the subaerial and submerged zones. Local geological and environmental factors, as well as the coastal management strategies applied, will influence how the beach responds to winter wave events. Monitoring and understanding these responses are essential for effective coastal management and adaptation to changing climate.Xunta de Galicia | Ref. ED481D2019/028Fundação para a Ciência e a Tecnologia | Ref. UIDP/50017/2020Fundação para a Ciência e a Tecnologia | Ref. UIDB/50017/2020Fundação para a Ciência e a Tecnologia | Ref. LA/P/0094/202

An in situ intercomparison exercise on passive samplers for the monitoring of metals, polycyclic aromatic hydrocarbons and pesticides in surface water

An intercomparison exercise on passive samplers (PSs) was organized in summer 2010 for the measurement of selected metals, polycyclic aromatic hydrocarbons (PAHs) and pesticides in surface waters. Various PSs were used and compared at 2 rivers sites and one marine lagoon. A total of 24 laboratories participated. We present selected significant outputs from this exercise, including discussion on quality assurance and quality control for PSs, the interlaboratory variability of field blanks, time weighted average water concentrations and its uncertainties, the representativity of DGT samples, the ability of PSs to lower limits of detection, PAH fingerprints in various PSs compared with spot samples, and the relevance of the permeability reference compounds (PRC) approach for POCIS with pesticides. These in situ intercomparison exercises should enable to progress on the harmonization of practices for the use of passive sampling, especially for priority chemical monitoring and regulatory programs in compliance with the Water Framework Directive (WFD) and Marine Strategy Framework Directive (MSFD)

Towards the growth of Cu2ZnSn1 xGexS4 thin films by a single stage process Effect of substrate temperature and composition

Cu2ZnSn1-xGexS4 (CZTGS) thin films prepared by flash evaporation of a Zn-rich Cu2ZnSn0.5Ge0.5S4 bulk compound in powder form, and a subsequent thermal annealing in S containing Ar atmosphere are studied. The effect of the substrate temperature during evaporation and the initial composition of the precursor powder on the growth mechanism and properties of the final CZTGS thin film are investigated. The microstructure of the films and elemental depth profiles depend strongly on the growth conditions used. Incorporation of Ge into the Cu2ZnSnS4 lattice is demonstrated by the shift of the relevant X-ray diffraction peaks and Raman vibrational modes towards higher diffraction angles and frequencies respectively. A Raman mode at around 348-351 cm-1 is identified as characteristic of CZTGS alloys for x = [Ge]/([Sn]+[Ge]) = 0.14-0.30. The supply of Ge enables the reduction of the Sn loss via a saccrifical Ge loss. This fact allows increasing the substrate temperature up to 350º C during the evaporation, forming a high quality kesterite material and therefore, reducing the deposition process to one single stageRC acknowledges financial support from Spanish MINECO within the Ramón y Cajal programme (RYC-2011-08521) and VIR for the Juan de la Cierva fellowship (JCI-2011-10782). GB also acknowledges the CSIC-JAE pre-doctoral program, co-funded by the European Social Fund. This work was supported by the Marie Curie-IRSES project (PVICOKEST, GA: 269167), Marie Curie-ITN project (KESTCELL, GA: 316488), DAAD project (INTERKEST, Ref: 57050358), and MINECO projects (SUNBEAM, ENE2013-49136-C4-3-R) (TEC2012-38901-C02-01). A. Scheu is acknowledged for GDOES measurement

Central banking and inequalities: taking off the blinders

What is the relation between monetary policy and inequalities in income and wealth? This question has received insufficient attention, especially in light of the unconventional policies introduced since the 2008 financial crisis. The article analyzes three ways in which the concern central banks show for inequalities in their official statements remains incomplete and underdeveloped. First, central banks tend to care about inequality for instrumental reasons only. When they do assign intrinsic value to containing inequalities, they shy away from trade-offs with the standard objectives of monetary policy that such a position entails. Second, central banks play down the causal impact monetary policy has on inequalities. When they do acknowledge it, they defend their actions by claiming that it is an unintended side effect, that it is temporary, and/or that any alternative policy would fare even worse. The article appeals to the doctrine of double effect to criticize these arguments. Third, even if one accepts that inequalities should be contained and that today’s monetary policies exacerbate them, is it both desirable and feasible to make containing inequalities part of the mandate of central banks? The article analyzes and rejects three attempts on the part of central banks to answer this question negatively

Developing Therapies for C3 Glomerulopathy: Report of the Kidney Health Initiative C3 Glomerulopathy Trial Endpoints Work Group

Copyright \ua9 2024 The Author(s). Published by Wolters Kluwer Health, Inc.Randomized clinical trials are underway to evaluate the efficacy of novel agents targeting the alternative complement pathway in patients with C3 glomerulopathy (C3G), a rare glomerular disease. The Kidney Health Initiative convened a panel of experts in C3G to (1) assess the data supporting the use of the prespecified trial end points as measures of clinical benefit and (2) opine on efficacy findings they would consider compelling as treatment(s) of C3G in native kidneys. Two subpanels of the C3G Trial Endpoints Work Group reviewed the available evidence and uncertainties for the association between the three prespecified end points - (1) proteinuria, (2) eGFR, and (3) histopathology - and anticipated outcomes. The full work group provided feedback on the summaries provided by the subpanels and on what potential treatment effects on the proposed end points they would consider compelling to support evidence of an investigational product\u27s effectiveness for treating C3G. Members of the full work group agreed with the characterization of the data, evidence, and uncertainties, supporting the end points. Given the limitations of the available data, the work group was unable to define a minimum threshold for change in any of the end points that might be considered clinically meaningful. The work group concluded that a favorable treatment effect on all three end points would provide convincing evidence of efficacy in the setting of a therapy that targeted the complement pathway. A therapy might be considered effective in the absence of complete alignment in all three end points if there was meaningful lowering of proteinuria and stabilization or improvement in eGFR. The panel unanimously supported efforts to foster data sharing between academic and industry partners to address the gaps in the current knowledge identified by the review of the end points in the aforementioned trials