Granulopoiesis inhibition in acute inflammation: comparative studies in healthy and leukaemic mice

It was demonstrated previously that mice undergoing an inflammatory reaction induced by subcutaneous (SC) implantation of copper rods, produce humoral factors that initially enhance, but subsequently inhibit, diffusion chamber (DC) granulopoiesis. This provided evidence that granulopoiesis is under the control of both humoral stimulators and inhibitors. In order to test the granulopoietic regulatory mechanism in leukaemic mice, we investigated the regulatory role of granulopoietic humoral inhibitors during in vivo granulopoiesis. We noticed that mice suffering from acute myeloid leukaemia (AML) are unable to augment the production of these humoral inhibitory factors when acute inflammation is induced, since no change in DC cell content was observed with or without prior inflammation. Moreover, unlike healthy mice, the serum of leukaemic mice withdrawn during the inhibition phase of acute inflammation did not show any inhibitory activity toward granulocyte—monocyte (GM) colony growth in vitro. Our results also show that increased levels of normal humoral inhibitors do not influence the proliferation and/or differentiation of leukaemic cells implanted in diffusion chamber cultures

Iron absorption in protein-energymal nutrition

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Pathophysiology of the anemia of protein-energy malnutrition -- 20

info:eu-repo/semantics/publishe

Hématologie et hémostase: physiologie

MEDinfo:eu-repo/semantics/published

A reassessment of intravascular volume measurements in protein—calorie malnutrition

Abstract. Accurate determination of plasma volume is difficult in oedematous protein–calorie malnutrition, but present studies on the equilibration of labelled red cells have shown that red cell volume measurements are valid in this syndrome. The red cell volumes have been measured in afflicted Bantu children during a refeeding programme. Expression of the results in ml/kg, ml/m2 or ml/cm is misleading and has been replaced by expressing the results as a percentage of the means of the normal values for the height. The results show that the red cell volume increase that ought to occur at the end of re‐feeding programme (and hence the iron requirement) is far higher than suggested by the packed cell volume. With treatment the red cell volume increases slowly. The red cell volume and plasma volume changes that occur during treatment do not take place at the same rate. Copyright © 1977, Wiley Blackwell. All rights reservedSCOPUS: ar.jFLWNAinfo:eu-repo/semantics/publishe

Heparin-associated thrombocytopenia: An update

SCOPUS: re.jinfo:eu-repo/semantics/publishe

Hématologie et hémostase: physiologie

2e candidature en biologie médicaleinfo:eu-repo/semantics/published

Hématologie et hémostase: physiologie

info:eu-repo/semantics/published

Exhausted platelets in cancer and other conditions

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

L'hémophilie A en Belgique au cours des 40 dernières années

SCOPUS: re.jinfo:eu-repo/semantics/publishe