The 4^4He(e,e′p)3(e,e^\prime p)^3H Reaction with Full Final--State Interaction

An {\it ab initio} calculation of the $^4$He$(e,e^\prime p)^3$H longitudinal response is presented. The use of the integral transform method with a Lorentz kernel has allowed to take into account the full four--body final state interaction (FSI). The semirealistic nucleon-nucleon potential MTI--III and the Coulomb force are the only ingredients of the calculation. The reliability of the direct knock--out hypothesis is discussed both in parallel and in non parallel kinematics. In the former case it is found that lower missing momenta and higher momentum transfers are preferable to minimize effects beyond the plane wave impulse approximation (PWIA). Also for non parallel kinematics the role of antisymmetrization and final state interaction become very important with increasing missing momentum, raising doubts about the possibility of extracting momentum distributions and spectroscopic factors. The comparison with experimental results in parallel kinematics, where the Rosenbluth separation has been possible, is discussed.Comment: 17 pages, 5 figure

V. N. Vinogradov Faculty Therapy Clinic of Sechenov University: the flagship of the therapeutic service of the Russian Federation. A review

The history of the Faculty Therapy Clinic of Sechenov University is presented. The stages of the formation of its therapeutic school are discussed. Diagnostic and therapeutic methods first developed and implemented in the clinic are described in detail

Two-body Photodisintegration of 4^{4}He with Full Final State Interaction

The cross sections of the processes $^4$He($\gamma,p$)$^3$H and $^4$He($\gamma,n$)$^3$He are calculated taking into account the full final state interaction via the Lorentz integral transform (LIT) method. This is the first consistent microscopic calculation beyond the three--body breakup threshold. The results are obtained with a semirealistic central NN potential including also the Coulomb force. The cross sections show a pronounced dipole peak at 27 MeV which lies within the rather broad experimental band. At higher energies, where experimental uncertainties are considerably smaller, one finds a good agreement between theory and experiment. The calculated sum of three-- and four--body photodisintegration cross sections is also listed and is in fair agreement with the data.Comment: 18 pages, 6 figure

Disorders in the System of Mineral and Bone Metabolism Regulators—FGF-23, Klotho and Sclerostin—in Chronic Kidney Disease: Clinical Significance and Possibilities for Correction

The chapter discusses the current understanding of the system of mineral and bone metabolism regulators—FGF-23, Klotho and sclerostin—disturbances in chronic kidney disease (CKD). In the chapter we presented the date, including our own results, which allow to suggest the change in the ratio of FGF-23-Klotho-sclerostin in CKD as an early biomarker not only for the chronic kidney damage but also for high cardiovascular (CV) risk. Results of studies show that disorders in FGF-23-Klotho-sclerostin ratio correlate with the frequency and severity of hypertension, vascular calcification, cardiac remodelling, anaemia, malnutrition, inflammation and strong aggravate CV risk in CKD. It was found independent from blood pressure (BP) action of increased serum FGF-23 on the myocardium as well as the correlation of serum high-sensitive troponin I with increased serum FGF-23 and low Klotho levels in CKD patients. At the same time, it was shown that renoprotective therapy, including renin-angiotensin blockers, low-protein diet with amino/keto acid supplementation and phosphate binders, erythropoiesis stimulators, vitamin D metabolites used to get the target levels of BP, serum phosphorus, haemoglobin, parathyroid hormone and nutritional status disorders correction can reduce the risk of CV events, as the major cause of death in CKD patients

Anemia and quality of life of chronic kidney disease patients on renal replacement therapy by programmed hemodialysis

Aim. To study relationship between anemia and health-related quality of life (HRQOL) of chronic kidney disease stage 5 patients (CKD) undergoing renal replacement therapy by programmed hemodialysis. Materials and Methods. The study was conducted on the basis of dialysis centers/departments in Moscow. The Russian-language version of the KDQOL-SFTM questionnaire, validated in Russia, was used to assess the HRQOL of patients on hemodialysis. A total of 723 patients were interviewed. Hemoglobin (Hb) levels were assessed in 442 patients based on outpatient records. To identify the relationship between Hb level and HRQOL scales, a correlation analysis was performed, as well as a HRQOL analysis in the three groups differing in hemoglobin levels (100; 100-120 and 120 g/l). Statistical data processing was carried by SPSS.22 and using parametric and nonparametric statistical methods. Results. Correlation relationship was revealed between Hb and HRQOL of patients on hemodialysis on the scales "symptoms/problems", "pain", "vital activity, energy" and "total physical component of health". According to the scales "symptoms/problems" and "vital activity, energy", higher rates were noted among patients with Hb higher than the target level, which confirms the recommendations concerning the possibility of achieving higher Hb among individual patients who have not serious concomitant diseases and cardiovascular complications in order to improve their quality of life. Conclusion. HRQOL assessment is important tool for planning and evaluating the effectiveness of anemia drug therapy among patients with CKD on hemodialysis

Nutritional Status Disorders in Chronic Kidney Disease: Practical Aspects (Systematic Review)

Despite the significant achievements in the management of chronic kidney disease (CKD) patients, the mortality rate of these patients still remains high. Nutritional status disorders (NSD) are considered now as one of the prognostic risk factors not only for dialysis but also for predialysis CKD stages. Since the publication of KDIGO 2012 guidelines for CKD patient’s management, there has been some significant advancement in our understanding of main NSD mechanisms in CKD, including different nosological group patients (first, in diabetic and systemic diseases patients). At the same time, there is still an urgent need for randomized trials for better-informed decisions and future optimization of CKD patients’ care. This chapter provides the current data on all aspects of NSD in CKD: etiology, diagnosis, prevention, and treatment approaches, as well as on risk factors of NSD at predialysis stages and in chronic hemodialysis patients. Considerable attention was devoted to the diagnosis and differential diagnosis of NSD in CKD patients. It was determined that the overall strategy for dietary treatment contributed to improving the life quality of patients and slowing down of CKD progression. The review is written based on the published results of clinical studies performed on the position of evidence-based medicine

Anemia in Chronic Kidney Disease and After Kidney Allotransplantation (Systematic Review)

Anemia in chronic kidney disease (CKD) has been recognized as a separate independent risk factor of cardiovascular (CV) events. The aim of the review is to provide a literature summary concerning early diagnosis and treatment of anemia in CKD that may be useful for clinicians and contribute to decrease CV mortality. Literature searches were made in such major databases as: PubMed, Medline, Embase, Cochrane Library, CINAHL, Wiley Online Library, Scopus, Web of Science, e-library, and website of WHO. This search encompassed original articles, systematic reviews, and meta-analyses relevant to CKD and anemia over recent 15 years. A total of 54 references from 562 reviewed articles were selected as they met to the search criteria (anemia and CKD, including diabetes mellitus, systemic diseases and post-transplant anemia). The publications included 27 randomized controlled trials, 20 experimental studies representing new data on the links of CKD anemia and cardiovascular risk markers (cytokines, Klotho, fibroblast growth factor (FGF-23), hyperglycemia, hypoalbuminemia and some others), 4 systematic reviews and 3 clinical practice guidelines. The main attention was devoted to the analysis of the studies provided an early diagnosis of anemia, an ability to minimize the factors contributing to its severity that have allowed to improve CV and total outcomes and to reduce costs of hospital treatment of CKD patients with anemia

Establishing of local population, population dynamics and current abundance of Steller sea lion ( <i>Eumetopias jubatus</i>) in the Commander Islands

The time course of the establishment of a local population of Steller sea lions in the Commander Islands, population dynamics and current abundance were studied using literature published since the 1930s and the author’s observations conducted during breeding seasons 2008-2011. The local population of Steller sea lions started formation in the early 1960s, when mature females first began to populate the islands and the population was fully established in the early 1990s. The whole process of development the Commander Islands Steller sea lion sub-population took about three decades. Abundance of adult and juvenile sea lions fluctuated highly in 1991-2011 without any statistically significant trend, but numbers of pups had a pronounced negative slope mostly due to three sharp declines in pup production in 2000, 2009, and 2011. A total of about 700 animals of age 1+ inhabit the islands during the breeding season and about 200 pups are born annually at the present time. This total number of Steller sea lions is close to the mean value for the period after 1990s. Nevertheless, occasional sharp declines in pup production cause some anxiety, so far as they could lead to extinction of the Steller sea lion sub-population in this area as had occurred in the middle of the 19th century

Theory of magnetoresistance in films of dilute magnetic alloys

Earlier a magnetic anisotropy for magnetic impurities nearby the surface of non-magnetic host was proposed in order to explain the size dependence of the Kondo effect in dilute magnetic alloys. Recently Giordano has measured the magnetoresistance of dilute Au(Fe) films for different thicknesses well above the Kondo temperature $T_K$. In this way he verified the existence of that anisotropy even for such a case where the Kondo effect is not dominating. For detailed comparison of that suggestion with experiments, the magnetic field dependence of the magnetoresistance is calculated in the lowest approximation, thus in the second order of the exchange coupling. The strength of the anisotropy is very close to earlier estimates deduced from the size dependence of the Kondo resistivity amplitude.Comment: (11 pages, 8 figures, essential changes compared to the old version

Electric dipole moments and the search for new physics

Static electric dipole moments of nondegenerate systems probe mass scales for physics beyond the Standard Model well beyond those reached directly at high energy colliders. Discrimination between different physics models, however, requires complementary searches in atomic-molecular-and-optical, nuclear and particle physics. In this report, we discuss the current status and prospects in the near future for a compelling suite of such experiments, along with developments needed in the encompassing theoretical framework.Comment: Contribution to Snowmass 2021; updated with community edits and endorsement