2 research outputs found
Design and synthesis of new benzophenone derivatives with in vivo anti-inflammatory activity through dual inhibition of edema and neutrophil recruitment.
A series of novel benzophenone derivatives containing a thiazole heterocyclic nucleus
were designed by molecular hybridization. Molecular docking studies have demonstrated the
inhibitory potential of the designed compounds against cyclooxygenase (COX) isoenzymes. These
compounds were synthesized, characterized, and evaluated for their anti-inflammatory properties
by the croton oil-induced ear edema assay to examine their effect on both prostaglandin (PG)
production and neutrophils recruitment. The thiazole derivatives displayed a potent effect in terms
of reducing ear edema. The analysis suggested that the presence of 4-phenyl-2-hydrazinothiazole
and the absence of C40
-OCH3 on the benzophenone derivative structure are strongly related to the
inhibition of PG production. In addition, the derivatives 2e, 3a and 3c concomitantly inhibit PG
production and neutrophil recruitment, which may be a mechanism of action better than of common
NSAIDs due to their inability to inhibit the neutrophil recruitment. Thus, these compounds can be
considered as potential lead compounds toward the development of new anti-inflammatory drugs
with an innovating mechanism of actio
Synthesis, chemical characterization and antimicrobial activity of new acylhydrazones derived from carbohydrates.
A new series of glycosylated acylhydrazones was synthesized and all the chemical structures were
confirmed by High Resolution Mass Spectrometry (HRMS), 1
H and 13C Nuclear Magnetic Resonance (1
HNMR; 13C-NMR) and Fourier Transform Infrared (FTIR) spectroscopy methods. The mass accuracy between the calculated and found values observed in HRMS analyses were near or lower than 5 ppm, which
are acceptable for proposing a molecular formula using this technique. All of the synthesized compounds
were screened for their antibacterial, antifungal and antiviral activities. Five compounds (12, 13, 14, 16
and 19) exerted a modest antifungal activity against the strains evaluated. Derivative 14 showed
fungicidal activity against Candida glabrata at 173.8 mM and saccharide unit contributed to the increase of
the antifungal potential against this strain. New chemical manipulation of derivative 14 can make it
possible to obtain new potentially antimicrobial agents