Il trattamento del gozzo immerso. La nostra esperienza

Gli Autori, dopo avere accennato alla storia naturale del gozzo immerso, riferiscono la loro esperienza di tale patologia maturata negli ultimi 5 anni, sottolineando i caratteri della complessa sintoma - tologia osservata nei vari casi, la condotta terapeutica seguìta, i buoni risultati ottenuti. Si soffermano quindi ad elencare le molteplici classificazioni, via via proposte. Illustrano le complesse situazioni sia di ordine emodina - mico che respiratorio di particolare interesse anestesiologico. Discutono, infine, sulla diagnostica e soprattutto sul corretto atteggiamento terapeutico il cui obiettivo è duplice: risolvere la sinto - matologia prodotta dalla massa mediastinica ed escludere la possibi - lità di recidiv

Hypophosphatemia as Unusual Cause of ARDS in Cushing’s Syndrome Secondary to Ectopic CRH Production. A Case Report

Hypophosphatemia is an unusual cause of acute respiratory distress syndrome (ARDS). We describe a hypophosphatemia-related ARDS case report of a 50-year-old woman with ACTH dependent Cushing's syndrome secondary to ectopic CRH production. The patient clinically showed hypotension tachypnea and increasing dyspnea. Laboratory data showed carbohydrate intolerance, severe hypokalemia, and hypophosphatemia. Arterial blood gases measurement revealed hypocapnia and elevation in bicarbonate values. Chest X-ray showed diffuse bilateral alveolar infiltrates similar to acute pulmonary edema and Kerley's striae. Chest CT scan evidenced diffuse ground glass opacification, bilateral patchy consolidation, and fibrosis, compatible with the recovery phase of ARDS. Clinical symptoms and laboratory examinations supported the diagnosis of ARDS. The patient was managed with supplemental potassium, octreotide, and oxygen therapy. Hypophosphatemia was managed by treating the underlying disorder. Successive surgical removal of the adrenal gland led to complete resolution of Cushing's syndrome. In conclusion, although rare and associated with specific risk factors, hypophosphatemia should be suspected in patients who develop unexplained ARDS

Biofluid Biomarkers in Huntington's Disease

Huntington's disease (HD) is a chronic progressive neurodegenerative condition where new markers of disease progression are needed. So far no disease-modifying interventions have been found, and few interventions have been proven to alleviate symptoms. This may be partially explained by the lack of reliable indicators of disease severity, progression, and phenotype.Biofluid biomarkers may bring advantages in addition to clinical measures, such as reliability, reproducibility, price, accuracy, and direct quantification of pathobiological processes at the molecular level; and in addition to empowering clinical trials, they have the potential to generate useful hypotheses for new drug development.In this chapter we review biofluid biomarker reports in HD, emphasizing those we feel are likely to be closest to clinical applicability

L’église et les Normands en Italie du Sud et en Sicile

La conquête normande en Italie était destinée à unifier dans le Royaume de Sicile des populations chrétiennes, de rite soit gréco-byzantin soit latino-romain, et des populations musulmanes. À l’entreprise normande la papauté ne pouvait pas rester indifférente pour plusieurs raisons. La conquête coïncidait avec le renouveau de la papauté romaine, qui, avec Léon IX, prit l’initiative du mouvement réformateur dans l’Église latine. Elle coïncidait aussi avec le conflit entre Rome et le patriarcat..

Fréderic II savant et empereur

C’est le même empereur, Frédéric II, qui s’est plu à défendre et à cultiver sa réputation d’homme de culture et de science, à affirmer la valeur de la lecture et de l’étude qu’il avait pratiquées depuis l’âge le plus tendre, à allier l’intérêt et la culture personnelle à la promotion et à la diffusion de la science et au soutien des savants, à affirmer enfin l’utilité des sciences pour le gouvernement des peuples. Frédéric se présente lui-même comme un homme de science et il est reconnu comme..