Correction: Braverman, E.R., et al. Managing Terrorism or Accidental Nuclear Errors, Preparing for Iodine-131 Emergencies: A Comprehensive Review. Int. J. Environ. Res. Public Health 2014, 11, 4158–4200

The authors wish to make the following amendments to their paper published in International Journal of Environmnetal Research and Public Health [1]: [...

Menopause Analytical Hormonal Correlate Outcome Study (MAHCOS) and the association to brain electrophysiology (P300) in a clinical setting.

Various studies have demonstrated that increased leptin levels and obesity are inversely related to cognitive decline in menopausal women. It is hypothesized that adiposity is inversely correlated with cognitive decline, as women with increased weight are less vulnerable to diminishing cognition. However, it is increasingly observed that menopausal women, even with increased adiposity, experience significant cognitive decline. Positron emission tomography (PET) has been used to analyze cognitive function and processing in menopausal women. Evoked potentials (P300) and neurophysiologic tests have validated brain metabolism in cognitively impaired patients. Post-hoc analyses of 796 female patients entering PATH Medical Clinic, between January 4, 2009 and February 24, 2013, were performed as part of the "Menopause Analytical Hormonal Correlate Outcome Study" (MAHCOS). Patient age range was 39-76 years (46.7 ± 0.2). P300 latency and amplitude correlated with a number of hormones: follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, estrone, estriol, DHEA, pregnenolone, progesterone, free and total testosterone, thyroid stimulating hormone (TSH), Vitamins D 1.25 and D 25OH, leptin, and insulin-like growth factor-binding protein 3 (IGF-BP3). Corrected statistics did not reveal significant associations with P300 latency or amplitude for these hormones except for leptin plasma levels. However, factor analysis showed that FSH and LH clustered together with Vitamin D1.25 and Vitamin D25OH, P300 latency (not amplitude), and log leptin were found to be associated in the same cluster. Utilizing regression analysis, once age adjusted, leptin was the only significant predictor for latency or speed (p = 0.03) with an effect size of 0.23. Higher plasma leptin levels were associated with abnormal P300 speed (OR = 0.98). Our findings show a significant relationship of higher plasma leptin levels, potentially due to leptin resistance, and prolonged P300 latency. This suggests leptin resistance may delay electrophysiological processing of memory and attention, which appears to be the first of such an association

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Principal Component Analysis in the Raw Scale Standardized Components.

<p>Principal Component Analysis in the Raw Scale Standardized Components.</p

Association between FSH and P300 Speed/Voltage.

<p>Association between FSH and P300 Speed/Voltage.</p

Principal Component Analysis in the Raw Scale Cluster Members.

<p>Principal Component Analysis in the Raw Scale Cluster Members.</p

Association between FSH and P300 Speed/Voltage for FSH under 100.

<p>Association between FSH and P300 Speed/Voltage for FSH under 100.</p

Menopause Questionnaire.

<p>Menopause Questionnaire.</p

Principal Component Analysis in the Log Scale Score and Loading Plot.

<p>Principal Component Analysis in the Log Scale Score and Loading Plot.</p

Association between FSH and P300 Speed/Voltage for FSH under 80.

<p>Association between FSH and P300 Speed/Voltage for FSH under 80.</p