Risk of bias assessment for the included randomized controlled trials.

<p>Based on the Cochrane Collaboration’s tool for assessing risk of bias, + indicates low risk of bias,—indicates high risk of bias, and? indicates unclear risk of bias.</p

Characteristics of included studies conducted in community settings.

<p>Characteristics of included studies conducted in community settings.</p

Characteristics of studies conducted in primary care.

<p>Characteristics of studies conducted in primary care.</p

Outcomes by intervention and control groups (if applicable) for studies conducted in primary care.

<p>Outcomes by intervention and control groups (if applicable) for studies conducted in primary care.</p

PRISMA flow diagram of study selection.

<p>PRISMA flow diagram of study selection.</p

Forrest plot of the meta-analysis for studies of cognitive behavioral therapy in primary care.

<p>Control condition entered in meta-analyses specified by study: Arean (2005) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0184666#pone.0184666.ref024" target="_blank">24</a>] used clinical case-management; but, Laidlaw (2008) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0184666#pone.0184666.ref028" target="_blank">28</a>], Lamers (2010) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0184666#pone.0184666.ref029" target="_blank">29</a>], Serfaty (2009) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0184666#pone.0184666.ref031" target="_blank">31</a>] used care as usual. One of the two reported outcome measurements by Laidlaw was used in the meta-analyses, namely HRSD.</p

Outcomes among intervention and control groups (if applicable) for included studies conducted in community settings.

<p>Outcomes among intervention and control groups (if applicable) for included studies conducted in community settings.</p