Vitamin B12 in older Australians

The prevalence of low blood levels of the vitamins folate and B12 increase as people age and can lead to several potential poor health outcomes. Low folate can cause gastrointestinal tract disturbances and megaloblastic anaemia (reduced number of abnormally large red blood cells). Low vitamin B12 can also cause anaemia as well as neuropathy (nerve damage) with problems such as difficulties with walking, tingling of the hands and feet, and cognitive decline such as memory loss. We recently published data about a population-based group of 2901 older people in the Blue Mountains, aged 50 years and over, collected as part of the Blue Mountains Cohort Study with the Centre for Vision Research. Low serum vitamin B12 was found in 22.9% of participants and low serum folate in 2.3% of participants. The proportion of people with low serum vitamins increased with age, particularly amongst men

Seeing clearly with antioxidants

While the evidence pointing to the cause of AMD has been mixed, a few studies have explored the role of diets. A large randomised control trial1 that looked at people with the onset of AMD showed that high-dose vitamins C and E, zinc and beta-carotene supplementation may slow AMD progression in relatively advanced early AMD cases by up to 25 per cent. Recently, another study2 showed evidence that an above-median dietary intake of these same nutrients was associated with a 35 per cent reduction in AMD risk

Dietary fatty acids and age-related macular degeneration

Age-related macular degeneration (AMD) is a leading cause of vision loss and blindness among older people. It is important to identify modifiable risk factors which could prevent or slow the progression of this chronic disease. Dietary fatty acid intakes have been investigated in epidemiological studies as it is plausible that individual lipids have properties which modulate cellular damage in the eye. This paper reviews epidemiological studies investigating links between fatty acids and AMD. Mixed evidence has related the sub-types of saturated and monounsaturated fatty acids to AMD, but nearly all epidemiological studies have demonstrated some level of AMD protection from omega-3 polyunsaturated fatty acids (particularly long-chain fatty acids) and fish, with a tendency for a corresponding dampening effect with increased dietary omega-6 polyunsaturated fatty acids

Trends in legume consumption among ethnically diverse adults in a longitudinal cohort study in Australia

Abstract presented at the Experimental Biology 2015 conference, 28 March-1 April 2015, Boston, United States

Report on the consumpton of vegetables and fruit in NSW

Increasing vegetable and fruit consumption in the New South Wales population is a key public health priority. There is little dispute that high vegetable and fruit consumption confers significant health benefits. Epidemiological evidence indicates that increasing intakes of vegetables and fruit decreases the risk of major chronic diseases including cancer, coronary heart disease, stroke, type 2 diabetes, diverticulitis, cataracts, macular degeneration, and chronic obstructive pulmonary disease. For optimal health benefits, the importance of consuming a variety of vegetables and fruit is stressed. It is also important that there appears to be a dose-response relationship between vegetable and fruit consumption and protection from ill health. Thus, important gains can be made by increasing consumption across all intake levels. It has been estimated, conservatively, that 3% of the total burden of disease in Australia is attributable to a low intake of vegetables and fruit. Expressed economically, the potential savings to the national health care system of increasing average vegetable consumption by only one serve per day is $24.4 million per year for colorectal, breast, lung, and prostate cancer alone

Dietary glycaemic index and glycaemic load among Australian children and adolescents

There are no published data regarding the overall dietary glycaemic index (GI) and glycaemic load (GL) of Australian children and adolescents. We therefore aim to describe the dietary GI and GL of participants of the 2007 Australian National Children’s Nutrition and Physical Activity Survey (2007ANCNPAS), and to identify the main foods contributing to their GL. Children, aged 2–16 years, who provided two 24 h recalls in the 2007ANCNPAS were included. A final dataset of 4184 participants was analysed. GI of each food item was assigned using a previously published method. GL was calculated, and food groups contributing to the GL were described by age group and sex. The weighted mean dietary GI and GL of the participants were 54 (SD 5) and 136 (SD 44), respectively. Among the nutrients examined, Ca had the highest inverse relationship with GI (P,0·001), while percentage energy from starch was most positively associated with GI. The association between fibre density and GI was modest, and percentage energy from sugar had an inverse relationship with GI. Daily dietary GL contributed by energy-dense and/or nutrient-poor (EDNP) items in subjects aged 14–16 years was more than doubled that of subjects aged 2–3 years. To conclude, Australian children and adolescents were having a high-GI dietary pattern characterised by high-starchy food intake and low Ca intake. A significant proportion of their dietary GL was from EDNP foods. Efforts to reduce dietary GI and GL in children and adolescents should focus on energy-dense starchy foods. Key words: Dietary glycaemic index: Glycaemic index: Glycaemic load: Australian: Childre

Prevalence and risks of fascioliasis among adult cohorts in Binh Dinh and Quang Ngai provinces-central Viet Nam

Fascioliasis (liver fluke disease) has raised significant public health concerns in the 15 regional provinces of Central Vietnam, accounting for 93% of the national incidence of the disease. No control measures to date have proven effective. Annual reports show increasing incidence of fascioliasis but they are incomplete. This cross-sectional study was conducted to identify the prevalence of fascioliasis and to describe its associated risks in three communes in Central Vietnam. 500 human blood samples were examined (ELISA); and a survey of knowledge, attitude and practice (KAP) was conducted for 600 randomly selected adults per commune. The findings suggest that overall seroprevalence was 7.75% (95% CI 6.54-9.16%). Among the infected cases, people aged from 18-59 years (85.6%) and farmers (68.0%) accounted for majority of infection. Less than half of participants in all three communes (24.6% - 46.0%) knew the causes of fascioliasis; and considerable proportions ate improperly boiled vegetables (28.2-33.8%), drank unboiled water (23.5-42.5%), and did not own a household toilet (14.2-20.5%). Relatively high prevalence and risks of fascioliasis were found in Central Vietnam, supporting the need for comprehensive intervention measures including selective treatment, health education, and multisectoral approaches to reduce the morbidity associated with fascioliasis and thus improve the health status of the people

Effectiveness of home based early intervention on children’s BMI at age 2: randomised controlled trial

Objective To assess the effectiveness of a home based early intervention on children’s body mass index (BMI) at age 2

Dietary flavonoids and the prevalence and 15-y incidence of age-related macular degeneration

Background: The majority of research performed to date has examined the effects of commonly known antioxidants such as vitamins C, E, and A and carotenoids on age-related macular degeneration (AMD) risk and progression. To date, there is limited research on promising phytochemicals with antioxidant and anti-inflammatory properties, including flavonoids. Objective: In this exploratory study, we aimed to assess the independent associations between dietary intake of total flavonoids and common flavonoid classes with the prevalence and 15-y incidence of AMD. Design: In this population-based cohort study, 2856 adults aged ≥49 y at baseline and 2037 followed up 15 y later were included in prevalence and incidence analyses, respectively. Dietary intake was assessed by using a semiquantitative food-frequency questionnaire (FFQ). Estimates of the flavonoid content of foods in the FFQ were assessed by using the USDA Flavonoid, Isoflavone, and Proanthocyanidin databases. AMD was assessed from retinal photographs. Results: In cross-sectional analysis, each 1-SD increase in total overall flavonoid intake was associated with a reduced likelihood of any AMD (multivariable-adjusted OR: 0.76; 95% CI: 0.58, 0.99). Each 1-SD increase in dietary intake of total flavonols and total flavanones was associated with reduced odds of the prevalence of any AMD [multivariable-adjusted OR (95% CI): 0.75 (0.58, 0.97) and 0.77 (0.60, 0.99), respectively]. A marginally significant trend (P = 0.05) was observed between increasing the intake of total flavanone and hesperidin (from the first to the fourth quartile) and reduced likelihood of incident late AMD, after multivariable adjustment. Participants who reported ≥1 serving of oranges/d compared with those who never consumed oranges at baseline had a reduced risk of late AMD 15 y later (multivariable-adjusted OR: 0.39; 95% CI: 0.18, 0.85). Conclusions: Our findings suggest an independent and protective association between dietary intake of flavonoids and the likelihood of having AMD. Additional prospective cohort studies are needed to validate these findings

Illawarra Born cross-generational health study: feasibility of a multi-generational birth cohort study

Background: There is a strong interest in the concept of developmental origins of health and disease and their influence on various factors from cradle to grave . Despite the increasing appreciation of this lifelong legacy across the human life course, many gaps remain in the scientific understanding of mechanisms influencing these formative phases. Cross-generational susceptibility to health problems is emerging as a focus of research in the context of birth cohort studies. The primary aim of the Illawarra Born study is to make scientific discoveries associated with improving health and wellbeing across the lifespan, with a particular focus on preventable chronic diseases, especially mental health. This birth cohort study will follow and collect data from three cohorts representing different stages across the lifespan: infants, adults (parents) and older adults (grandparents). The multi-generational, cross-sectional and longitudinal design of this birth cohort study supports a focus on the contributions of genetics, environment and lifestyle on health and wellbeing. The feasibility of conducting a multi-generational longitudinal birth cohort project was conducted through a small pilot study. Methods/design: The purpose of this paper is to report on the feasibility and acceptability of the research protocol for a collaborative cross-generation health study in the community and test recruitment and outcome measures for the main study. This feasibility study included pregnant women who were intending to give birth in the Illawarra-Shoalhaven region in Eastern Australia. The area includes a large, regional referral hospital, with capacity to treat specialist and complex cases. Pregnant women were asked to participate in five data collection waves beginning at 22 weeks gestation and ending with a 6-month post-partum appointment. Recruitment was then extended, via the pregnant women, to also include fathers and maternal grandmothers. Discussion: This feasibility study focused on the perinatal period and collected data across three multi-disciplinary domains including mental health, diet, exposures to toxins and the role of these in maternal and infant outcomes. Forty-one families participated in extensive data collection from 22 weeks gestation to 6-months post-partum. Factors impacting on viability and feasibility including recruitment solutions provide the basis for a large-scale study