A solitary bronchial papilloma with unusual endoscopic presentation: case study and literature review

<p>Abstract</p> <p>Background</p> <p>Solitary endobronchial papillomas (SEP) are rare tumors and most of them are described by case report. A misdiagnosis is common with viral related papillomas. A histopathological classification has recently permitted a major advancement in the understanding of the disease.</p> <p>Case Presentation</p> <p>We report a case of a mixed bronchial papilloma with an unusual endoscopic presentation. The literature was extensively reviewed to ascertain the unusual characteristics of the current case. A 39-year of age male was referred to our institution for the investigation of a slight hemoptysis. Routine examination was normal. A fibroscopy revealed an unusual feature of the right main bronchus. The lesion was a plane, non-bleeding, non-glistering sub-mucosal proliferation. No enhanced coloration was noticed. Biopsies revealed a mixed solitary bronchial papilloma. In situ HPV hybridization was negative. Endoscopic treatment (electrocautery) was effective with no relapse.</p> <p>Conclusion</p> <p>This lesion contrasts with the data of the literature where papilloma were described as wart-like lesions or cauliflower tumors, with symptoms generally related to bronchial obstruction. We advise chest physicians to be cautious with unusually small swollen lesions of the bronchi that may reveal a solitary bronchial papilloma. Endoscopic imaging can significantly contribute to the difficult diagnosis of SEP by pulmonary physicians and endoscopists.</p

Gas chromatographic-mass spectrometric analysis of tannin hydrolysates from the ink of ancient manuscripts (XIth to XVIth century)

International audienceA procedure has been devised for determining the constituents of ink from ancient hand-written parchments. Some of the tannic acids and sugars resulting from acid hydrolysis of ink could be identified at the nanogram level (thus necessitating the destruction of only a small amount of ink from the manuscript) by gas chromatography-mass spectrometry of their trimethylsilyl derivatives. The presence of “ferrogallic” inks on some manuscripts was assumed from the detection of gallic acid and glucose by selection ion monitoring and capillary-column gas chromatography. The method has been applied to inks from eleven European manuscripts dating from the XIth to the XVIth century, and to various possible ink precursors (extracts from gall nuts, pods of Tara (Caesalpinia spinosa) and gum arabic)