COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Pre-Variscan geological events in the Austrian part of the Bohemian Massif deduced from U-Pb zircon ages

In an attempt to elucidate the pre-Variscan evolution history of the various geological units in the Austrian part of the Bohemian Massif, we have analysed zircons from 12 rocks (mainly orthogneisses) by means of SHRIMP, conventional multi-grain and single-grain U-Pb isotope-dilution/mass-spectrometry. Two of the orthogneisses studied represent Cadomian metagranitoids that formed at ca. 610 Ma (Spitz gneiss) and ca. 580 Ma(Bittesch gneiss). A metagranite from the Thaya batholith also gave a Cadomian zircon age (567-5 Ma). Traces of Neoproterozoic zircon growth were also identified in several other samples, underlining the great importance ofthe Cadomian orogeny for the evolution of crust in the southern Bohemian Massif. However, important magmatic events also occurred in the Early Palaeozoic. A sample of the Gfhl gneiss was recognised as a488-6 Ma-old granite. A tonalite gneiss from the realm of the South Bohemian batholith was dated at 456-3 Ma, and zircon cores in a Moldanubian metagranitic granulite gave similar ages of 440-450 Ma. This Ordovician phase of magmatism in the Moldanubian unit is tentatively interpreted as related to the rifting and drift of South Armorica from the African Gondwana margin. The oldest inherited zircons, in a migmatite from the South Bohemian batholith, yielded an age of ca. 2.6 Ga, and many zircon cores in both Moravian and Moldanubian metagranitoid rocks gave ages around 2.0 Ga. However, rocks from the Moldanubian unit show a striking lack of zircon ages between 1.8 and 1.0 Ga, reflecting an ancestry from Armorica and the North African part of Gondwana, respectively, whereas the Moravian Bittesch gneiss contains many inherited zircons with Mesoproterozoic and Early Palaeoproterozoic ages of ca. 1.2, 1.5 and 1.65?1.8 Ga, indicating a derivation from the South American part of Gondwan