PTSA CATALYZED KSF SOLID SUPPORTED MICHAEL ADDITION ON STYRYLISOXAZOLES AND THEIR REDUCTIVE CYCLIZATION TO AZEPINES

Abstract The Michel addition of styrylisoxazoles with ethyl benzoyl acetate in presence of ptoluene sulfonic acid (PTSA) catalyst supported on KSF solid furnished the Michael adducts in excellent yields in short time. The Michael adducts underwent reductive cyclization on treatment with SnCl 2 -MeOH to afford isoxazolo [4,5-b] azepines in high yields