The role of thiophenol in the proposed mechanism for one pot transformation of 2-phenylthio-3-aminocyclohexanols to dehydropiperidine derivatives

AbstractThis paper describes the effect of thiophenol concentration on photochemical rearrangement of 2-phenylthio-3-aminocyclohexanols to the corresponding protected aminoaldehydes. The obtained aminoaldehyde is in equilibrium with its corresponding deoxyazasugar. The latter could be converted to the corresponding dehydropiperidine with a good yield in the same reaction media by controlling the thiophenol concentration. Also a proposed mechanism for this one pot transformation is reported

Ab Initio

Ab initio calculation at RHF/6-31G* level of theory for geometry optimization of conformers of N-benzyl-2-phenylpyridinium ions are reported. The series of electron-withdrawing and electron-donating groups have been replaced by 3-H phenyl and benzyl of N-benzyl-2-phenylpyridinium ions and the energy difference between the syn- and anti- forms discussed in terms of π-π stacking

P-TSA/NaNO2/NaN3 a mild and efficient system for easy and fast conversion of arylamines to azides at room temperature

Abstract This article describes easy, fast and efficient method for the diazotization and azidation of different aromatic amines over p-TSOH hydrate, sodium nitrite and sodium azide under mild condition at room temperature. Various aryl amines possessing electron-withdrawing groups or electron-donating groups were converted into the corresponding aryl azides in 75-99% yields. The use of mild reaction conditions, avoiding the use of harmful acids and toxic solvents and short reaction time are advantages of this methodology. The selected catalyst is found to be highly efficient

A rapid and green synthesis of 1,1-diacetates from aldehydes catalyzed by triethylamine-bonded sulfonic acid [Et3NâSO3H]Cl

Bronsted acidic ionic liquid, [Et3N–SO3H]Cl, catalyzed the reaction of acetic anhydride with aryl aldehydes under solvent-free condition. Various 1,1-diacetates are obtained using 15 mol% of  triethylamine-bonded sulfonic acid in satisfactory to excellent yields in very short reaction times at ambient temperature. Different groups including electron donating or electron withdrawing groups linked to benzene ring such as methyl, chloro, nitro and methoxy were tolerated under the optimized reaction conditions. This ionic liquid was air stable and easily prepared from accessible amine and chlorosulfonic acid. The present report is a green protocol as it eliminates the need of an organic solvent. Very short reaction times, high yields, simple operational procedure and green conditions are merits of this methodology

Theoretical Studies of Using Amino Acids as a New Class of Antidote Drugs and their Possible Complexes with Zn2+as Antidote Drugs.

This paper introduces a new class of bidentate ligands as antidote drugs. By semi-empirical AM1 method calculations, we showed that natural amino acids could be used as theoretically good antidote drugs. To reach this goal, we have calculated the stability energies of glycine, alanine, valine, leucine, isoleucine, serine and threonine and their complexes with Zn2+ as indicated

Nano-Fe3O4 encapsulated-silica particles bearing sulfonic acid groups as an efficient, eco-friendly and magnetically recoverable catalyst for synthesis of various xanthene derivatives under solvent-free conditions

AbstractThis report describes an efficient method for the synthesis of 1,8-dioxo-octahydroxanthene, 14H-dibenzo[a,j]xanthene, 12-aryl-tetrahydrobenzo[a]xanthenes-11-one and 13-aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraone derivatives in the presence of a catalytic amount of nano-iron oxide encapsulated silica particles bearing sulfonic acid groups. Results present an efficient, environmentally friendly and magnetically recoverable catalyst under solvent-free conditions at 110–130°C

A Facile One-Pot Solvent-Free Synthesis of 1,2-Dihydro-1-arylnaphtho[1,2-e][1,3]oxazine-3-ones Catalyzed by Wet Cyanuric Chloride

A novel one-pot synthesis of 1,2-dihydro-1-arylnaphtho[1,2-e][1,3]oxazine-3-ones by condensation of a variety of aldehydes with β-naphthol and urea or thiourea in the presence of wet cyanuric chloride under solvent-free condition has been described. High yields, simple procedure, easy workup, short reaction times, and avoiding the use of organic solvent are the advantages of this green methodology

Ab Initio Study of Atropisomers of Derivatives of N-Benzyl-2-phenylpyridinium Ions

Ab initio calculation at RHF/6-31G* level of theory for geometry optimization of conformers of N-benzyl-2-phenylpyridinium ions are reported. The series of electron-withdrawing and electron-donating groups have been replaced by 3-H phenyl and benzyl of N-benzyl-2-phenylpyridinium ions and the energy difference between the syn- and anti- forms discussed in terms of π-π stacking

Bi-SO3H Functionalized Ionic Liquid Based on DABCO: New and Efficient Catalyst for Facile Synthesis of Dihydropyrimidinones

A simple and efficient method for the one-pot Biginelli condensation reaction of aldehydes, β-dicarbonyl compounds, and urea or thiourea employing [DABCO](SO3H)2Cl2 as a novel ionic liquid catalyst is described