C-Telopeptide Pyridinoline Cross-Links: Sensitive Indicators of Periodontal Tissue Destruction

C-telopeptides and related pyridinoline cross-links of bone Type I collagen are sensitive markers of bone resorption in osteolytic diseases such as osteoporosis and osteoarthritis. We have studied the release of C-telopeptide pyridinoline crosslinks of Type I collagen as measures of bone destruction in periodontal disease. Studies in preclinical animal models and humans have demonstrated the relationship between radiographic bone loss and crevicular fluid C-telopeptide levels. We have recently found that C-telopeptide levels correlate strongly with microbial pathogens associated with periodontitis and around endosseous dental implants. Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72598/1/j.1749-6632.1999.tb07698.x.pd

Effect of absorbable membranes on sandwich bone augmentation

Objectives : This study was conducted to evaluate the effect of barrier membranes on sandwich bone augmentation (SBA) for the treatment of implant dehiscence defects. Material and methods : Twenty-six implant-associated buccal dehiscence defects in 22 patients were treated according to the SBA concept – mineralized human cancellous allograft (inner layer), mineralized human cortical allograft (outer layer) and coverage with barrier membrane. The defects were randomly assigned to the bovine collagen membrane (BME) group; acellular dermal matrix (ADM) group; and no membrane group. Measurements at baseline and 6 months re-entry included defect height (DH: from smooth–rough junction to the most apical part of the defect), defect width (DW: at the widest part of the defect), and horizontal defect depth (HDD: at three locations – smooth–rough junction, middle, and most apical portion of the defect). All measurements were taken from a reference stent. Statistical analyses were performed for comparison of intra- and inter-group comparisons. Results : All implants placed were successfully osseointegrated. DH at baseline for three groups were not significantly different ( P =0.858). Mean % DH reductions for ADM, BME, and control groups at 6 months were 73.9±17.6%, 68.1±30.1%, and 63.6±23.9%, respectively, with no significant difference among the groups ( P =0.686). Mean horizontal bone gain, however, was significantly greater for membrane groups (1.7 mm for ADM, 1.6 mm for BME) compared with control group (1 mm) ( P =0.044). Implant exposure resulted in significant reduction in total height gain (79.1±14.3% vs. 57±23.5%, P =0.021). Conclusions : Within the limit of this study, it is concluded that SBA technique achieved predictable clinical outcomes. The addition of absorbable membranes enhanced bone gain in thickness compared with membrane-treated sites. To cite this article: Park S-H, Lee K-w, Oh T-J, Misch CE, Shotwell J, Wang H-L. Effect of absorbable membranes on sandwich bone augmentation. Clin. Oral Impl. Res . 19 , 2008; 32–41. doi: 10.1111/j.1600-0501.2007.01408.xPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74133/1/j.1600-0501.2007.01408.x.pd