Mutual Explanations for Cooperative Decision Making in Medicine

Exploiting mutual explanations for interactive learning is presented as part of an interdisciplinary research project on transparent machine learning for medical decision support. Focus of the project is to combine deep learning black box approaches with interpretable machine learning for classification of different types of medical images to combine the predictive accuracy of deep learning and the transparency and comprehensibility of interpretable models. Specifically, we present an extension of the Inductive Logic Programming system Aleph to allow for interactive learning. Medical experts can ask for verbal explanations. They can correct classification decisions and in addition can also correct the explanations. Thereby, expert knowledge can be taken into account in form of constraints for model adaption

The Next Generation of Medical Decision Support : A Roadmap Toward Transparent Expert Companions

Artikelnummer 507973Increasing quality and performance of artificial intelligence (AI) in general and machine learning (ML) in particular is followed by a wider use of these approaches in everyday life. As part of this development, ML classifiers have also gained more importance for diagnosing diseases within biomedical engineering and medical sciences. However, many of those ubiquitous high-performing ML algorithms reveal a black-box-nature, leading to opaque and incomprehensible systems that complicate human interpretations of single predictions or the whole prediction process. This puts up a serious challenge on human decision makers to develop trust, which is much needed in life-changing decision tasks. This paper is designed to answer the question how expert companion systems for decision support can be designed to be interpretable and therefore transparent and comprehensible for humans. On the other hand, an approach for interactive ML as well as human-in-the-loop-learning is demonstrated in order to integrate human expert knowledge into ML models so that humans and machines act as companions within a critical decision task. We especially address the problem of Semantic Alignment between ML classifiers and its human users as a prerequisite for semantically relevant and useful explanations as well as interactions. Our roadmap paper presents and discusses an interdisciplinary yet integrated Comprehensible Artificial Intelligence (cAI)-transition-framework with regard to the task of medical diagnosis. We explain and integrate relevant concepts and research areas to provide the reader with a hands-on-cookbook for achieving the transition from opaque black-box models to interactive, transparent, comprehensible and trustworthy systems. To make our approach tangible, we present suitable state of the art methods with regard to the medical domain and include a realization concept of our framework. The emphasis is on the concept of Mutual Explanations (ME) that we introduce as a dialog-based, incremental process in order to provide human ML users with trust, but also with stronger participation within the learning process

Uncovering the Bias in Facial Expressions

Over the past decades the machine and deep learning community has celebrated great achievements in challenging tasks such as image classification. The deep architecture of artificial neural networks together with the plenitude of available data makes it possible to describe highly complex relations. Yet, it is still impossible to fully capture what the deep learning model has learned and to verify that it operates fairly and without creating bias, especially in critical tasks, for instance those arising in the medical field. One example for such a task is the detection of distinct facial expressions, called Action Units, in facial images. Considering this specific task, our research aims to provide transparency regarding bias, specifically in relation to gender and skin color. We train a neural network for Action Unit classification and analyze its performance quantitatively based on its accuracy and qualitatively based on heatmaps. A structured review of our results indicates that we are able to detect bias. Even though we cannot conclude from our results that lower classification performance emerged solely from gender and skin color bias, these biases must be addressed, which is why we end by giving suggestions on how the detected bias can be avoided.Comment: Accepted at the colloquium "Forschende Frauen", University of Bamberg, 202

Deriving Temporal Prototypes from Saliency Map Clusters for the Analysis of Deep-Learning-based Facial Action Unit Classification

Reliably determining the emotional state of a person is a difficult task for both humans as well as machines. Automatic detection and evaluation of facial expressions is particularly important if people are unable to express their emotional state themselves, for example due to cognitive impairments. Identifying the presence of Action Units in a human’s face is a psychologically validated approach of quantifying which emotion is expressed. To automate the detection process of Action Units Neural Networks have been trained. However, the black-box nature of Deep Neural Networks provides no insight on the relevant features identified during the decision process. Approaches of Explainable Artificial Intelligence have to be applied to provide an explanation why the network came to a certain conclusion. In this work "Layer-Wise Relevance Propagation" (LRP) in combination with the meta analysis approach "Spectral Relevance Analysis" (SpRAy) is used to derive temporal prototypes from predictions in video sequences. Temporal prototypes provide an aggregated view on the prediction of the network by grouping together similar frames by considering relevance. Additionally, a specific visualization method for temporal prototypes is presented that highlights the most relevant areas for a prediction of an Action Unit. A quantitative evaluation of our approach shows that temporal prototypes aggregate temporal information well. The proposed method can be used to generate concise visual explanations for a sequence of interpretable saliency maps. Based on the above, this work shall provide the foundation for a new temporal analysis method as well as an explanation approach that is supposed to help researchers and experts to gain a deeper understanding of how the underlying network decides which Action Units are active in a particular emotional state

Verifying Deep Learning-based Decisions for Facial Expression Recognition

Neural networks with high performance can still be biased towards non-relevant features. However, reliability and robustness is especially important for high-risk fields such as clinical pain treatment. We therefore propose a verification pipeline, which consists of three steps. First, we classify facial expressions with a neural network. Next, we apply layer-wise relevance propagation to create pixel-based explanations. Finally, we quantify these visual explanations based on a bounding-box method with respect to facial regions. Although our results show that the neural network achieves state-of-the-art results, the evaluation of the visual explanations reveals that relevant facial regions may not be considered.Comment: accepted at ESANN 202

Generating Explanations for Conceptual Validation of Graph Neural Networks : An Investigation of Symbolic Predicates Learned on Relevance-Ranked Sub-Graphs

Graph Neural Networks (GNN) show good performance in relational data classification. However, their contribution to concept learning and the validation of their output from an application domain’s and user’s perspective have not been thoroughly studied. We argue that combining symbolic learning methods, such as Inductive Logic Programming (ILP), with statistical machine learning methods, especially GNNs, is an essential forward-looking step to perform powerful and validatable relational concept learning. In this contribution, we introduce a benchmark for the conceptual validation of GNN classification outputs. It consists of the symbolic representations of symmetric and non-symmetric figures that are taken from a well-known Kandinsky Pattern data set. We further provide a novel validation framework that can be used to generate comprehensible explanations with ILP on top of the relevance output of GNN explainers and human-expected relevance for concepts learned by GNNs. Our experiments conducted on our benchmark data set demonstrate that it is possible to extract symbolic concepts from the most relevant explanations that are representative of what a GNN has learned. Our findings open up a variety of avenues for future research on validatable explanations for GNNs

Explaining and Evaluating Deep Tissue Classification by Visualizing Activations of Most Relevant Intermediate Layers

Deep Learning-based tissue classification may support pathologists in analyzing digitized whole slide images. However, in such critical tasks, only approaches that can be validated by medical experts in advance to deployment, are suitable. We present an approach that contributes to making automated tissue classification more transparent. We step beyond broadly used visualizations for last layers of a convolutional neural network by identifying most relevant intermediate layers applying Grad-CAM. A visual evaluation by a pathologist shows that these layers assign relevance, where important morphological structures are present in case of correct class decisions. We introduce a tool that can be easily used by medical experts for such validation purposes for any convolutional neural network and any layer. Visual explanations for intermediate layers provide insights into a neural network’s decision for histopathological tissue classification. In future research also the context of the input data must be considered