10,077 research outputs found
Online open neuroimaging mass meta-analysis
We describe a system for meta-analysis where a wiki stores numerical data in
a simple format and a web service performs the numerical computation.
We initially apply the system on multiple meta-analyses of structural
neuroimaging data results. The described system allows for mass meta-analysis,
e.g., meta-analysis across multiple brain regions and multiple mental
disorders.Comment: 5 pages, 4 figures SePublica 2012, ESWC 2012 Workshop, 28 May 2012,
Heraklion, Greec
Cohesin biology meets the loop extrusion model
Extensive research has revealed that cohesin acts as a topological device, trapping chromosomal DNA within a large tripartite ring. In so doing, cohesin contributes to the formation of compact and organized genomes. How exactly the cohesin subunits interact, how it opens, closes, and translocates on chromatin, and how it actually tethers DNA strands together are still being elucidated. A comprehensive understanding of these questions will shed light on how cohesin performs its many functions, including its recently proposed role as a chromatid loop extruder. Here, we discuss this possibility in light of our understanding of the molecular properties of cohesin complexes
Binary inspiral, gravitational radiation, and cosmology
Observations of binary inspiral in a single interferometric gravitational
wave detector can be cataloged according to signal-to-noise ratio and
chirp mass . The distribution of events in a catalog composed of
observations with greater than a threshold depends on the
Hubble expansion, deceleration parameter, and cosmological constant, as well as
the distribution of component masses in binary systems and evolutionary
effects. In this paper I find general expressions, valid in any homogeneous and
isotropic cosmological model, for the distribution with and of
cataloged events; I also evaluate these distributions explicitly for relevant
matter-dominated Friedmann-Robertson-Walker models and simple models of the
neutron star mass distribution. In matter dominated Friedmann-Robertson-Walker
cosmological models advanced LIGO detectors will observe binary neutron star
inspiral events with from distances not exceeding approximately
, corresponding to redshifts of (0.26) for
(), at an estimated rate of 1 per week. As the binary system mass
increases so does the distance it can be seen, up to a limit: in a matter
dominated Einstein-deSitter cosmological model with () that limit
is approximately (1.7) for binaries consisting of two
black holes. Cosmological tests based on catalogs of the
kind discussed here depend on the distribution of cataloged events with
and . The distributions found here will play a pivotal role in testing
cosmological models against our own universe and in constructing templates for
the detection of cosmological inspiraling binary neutron stars and black holes.Comment: REVTeX, 38 pages, 9 (encapsulated) postscript figures, uses epsf.st
Wetting and Minimal Surfaces
We study minimal surfaces which arise in wetting and capillarity phenomena.
Using conformal coordinates, we reduce the problem to a set of coupled boundary
equations for the contact line of the fluid surface, and then derive simple
diagrammatic rules to calculate the non-linear corrections to the Joanny-de
Gennes energy. We argue that perturbation theory is quasi-local, i.e. that all
geometric length scales of the fluid container decouple from the
short-wavelength deformations of the contact line. This is illustrated by a
calculation of the linearized interaction between contact lines on two opposite
parallel walls. We present a simple algorithm to compute the minimal surface
and its energy based on these ideas. We also point out the intriguing
singularities that arise in the Legendre transformation from the pure Dirichlet
to the mixed Dirichlet-Neumann problem.Comment: 22 page
The Origin of Black Hole Entropy in String Theory
I review some recent work in which the quantum states of string theory which
are associated with certain black holes have been identified and counted. For
large black holes, the number of states turns out to be precisely the
exponential of the Bekenstein-Hawking entropy. This provides a statistical
origin for black hole thermodynamics in the context of a potential quantum
theory of gravity.Comment: 18 pages (To appear in the proceedings of the Pacific Conference on
Gravitation and Cosmology, Seoul, Korea, February 1-6, 1996.
Topological Entropy of Braids on the Torus
A fast method is presented for computing the topological entropy of braids on
the torus. This work is motivated by the need to analyze large braids when
studying two-dimensional flows via the braiding of a large number of particle
trajectories. Our approach is a generalization of Moussafir's technique for
braids on the sphere. Previous methods for computing topological entropies
include the Bestvina--Handel train-track algorithm and matrix representations
of the braid group. However, the Bestvina--Handel algorithm quickly becomes
computationally intractable for large braid words, and matrix methods give only
lower bounds, which are often poor for large braids. Our method is
computationally fast and appears to give exponential convergence towards the
exact entropy. As an illustration we apply our approach to the braiding of both
periodic and aperiodic trajectories in the sine flow. The efficiency of the
method allows us to explore how much extra information about flow entropy is
encoded in the braid as the number of trajectories becomes large.Comment: 19 pages, 44 figures. SIAM journal styl
Gravitational Waves from coalescing binaries: Estimation of parameters
The paper presents a statistical model which reproduces the results of Monte
Carlo simulations to estimate the parameters of the gravitational wave signal
from a coalesing binary system. The model however is quite general and would be
useful in other parameter estimation problems.Comment: LaTeX with RevTeX macros, 4 figure
The Cosmological Constant and Advanced Gravitational Wave Detectors
Interferometric gravitational wave detectors could measure the frequency
sweep of a binary inspiral [characterized by its chirp mass] to high accuracy.
The observed chirp mass is the intrinsic chirp mass of the binary source
multiplied by , where is the redshift of the source. Assuming a
non-zero cosmological constant, we compute the expected redshift distribution
of observed events for an advanced LIGO detector. We find that the redshift
distribution has a robust and sizable dependence on the cosmological constant;
the data from advanced LIGO detectors could provide an independent measurement
of the cosmological constant.Comment: 13 pages plus 5 figure, LaTeX. Revised and final version, to appear
in Phys. Rev.
Observational constraints on the neutron star mass distribution
Radio observations of neutron star binary pulsar systems have constrained
strongly the masses of eight neutron stars. Assuming neutron star masses are
uniformly distributed between lower and upper bounds and , the
observations determine with 95\% confidence that and . These limits give observational
support to neutron star formation scenarios that suggest that masses should
fall predominantly in the range , and will also be
important in the interpretation of binary inspiral observations by the Laser
Interferometer Gravitational-wave Observatory.Comment: Postscript, 4 pages, NU-GR-
Using Markov chain Monte Carlo methods for estimating parameters with gravitational radiation data
We present a Bayesian approach to the problem of determining parameters for
coalescing binary systems observed with laser interferometric detectors. By
applying a Markov Chain Monte Carlo (MCMC) algorithm, specifically the Gibbs
sampler, we demonstrate the potential that MCMC techniques may hold for the
computation of posterior distributions of parameters of the binary system that
created the gravity radiation signal. We describe the use of the Gibbs sampler
method, and present examples whereby signals are detected and analyzed from
within noisy data.Comment: 21 pages, 10 figure
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