Keeneland Conference Plenary Sessions: Harvey V. Fineberg

Healthy communities are essential for healthy individuals. Healthy communities can only exist when preventive measures are taken. When prevention programs are implemented, negative health outcomes can be avoided before they even start. A necessary part of these successful prevention methods requires great research and evidence based practice. Dr. Harvey Fineberg, president of the Institute of Medicine and keynote speaker at the Keeneland Conference, addressed the audience on why good science is imperative to the public health community. It cannot just left up to chance on whether an intervention will work or not; rather it needs to be thoroughly reasoned, grounded in evidence, and be assured to have positive outcomes. Fineberg tells us not to be afraid of using good science and packaging it in a way that will make sense to both policy makers and the general public alike

Foreword

Mr. McGuire: I want to say one word to you. Just one word.Benjamin: Yes, sir.Mr. McGuire: Are you listening?Benjamin: Yes, I am.Mr. McGuire: Plastics.Benjamin: Exactly how do you mean?Mr. McGuire: There’s a great future in plastics. Think about it. Will you think about it?[Dialogue from the film, The Graduate, 1967.] Plastics – versatile, flexible, strong, lightweight, durable, impervious to water, and inexpensive – are ubiquitous in modern life. In 1967, when the film, The Graduate, was rele..

Foreword

“The future cannot be predicted, but futures can be invented.”Dennis Gabor, 1963 (inventor of holography, winner of Nobel Prize in Physics, 1971) Our climate future is invented through human action, though not by an ingenious stroke of any single inventor. What we experience as climate and climate disruption is the product of many decades of human invention, mainly in the name of economic progress—to extract materials, generate power, multiply the harvest, and market new products. Mastery of ..

A functional alternative splicing mutation in human tryptophan hydroxylase-2

The brain serotonergic system has an essential role in the physiological functions of the central nervous system and dysregulation of serotonin (5-HT) homeostasis has been implicated in many neuropsychiatric disorders. The tryptophan hydroxylase-2 (TPH2) gene is the rate-limiting enzyme in brain 5-HT synthesis, and thus is an ideal candidate gene for understanding the role of dysregulation of brain serotonergic homeostasis. Here, we characterized a common, but functional single-nucleotide polymorphism (SNP rs1386493) in the TPH2 gene, which decreases efficiency of normal RNA splicing, resulting in a truncated TPH2 protein (TPH2-TR) by alternative splicing. TPH2-TR, which lacks TPH2 enzyme activity, dominant-negatively affects full-length TPH2 function, causing reduced 5-HT production. The predicted mRNA for TPH2-TR is present in postmortem brain of rs1386493 carriers. The rs13864923 variant does not appear to be overrepresented in either global or multiplex depression cohorts. However, in combination with other gene variants linked to 5-HT homeostasis, this variant may exhibit important epistatic influences

What do parents perceive are the barriers and facilitators to accessing psychological treatment for mental health problems in children and adolescents? A systematic review of qualitative and quantitative studies

A minority of children and adolescents with mental health problems access treatment. The reasons for poor rates of treatment access are not well understood. As parents are a key gatekeeper to treatment access, it is important to establish parents’ views of barriers/facilitators to accessing treatment. The aims of this study are to synthesise findings from qualitative and quantitative studies that report parents’ perceptions of barriers/facilitators to accessing treatment for mental health problems in children/adolescents. A systematic review and narrative synthesis were conducted. Forty-four studies were included in the review and were assessed in detail. Parental perceived barriers/facilitators relating to (1) systemic/structural issues; (2) views and attitudes towards services and treatment; (3) knowledge and understanding of mental health problems and the help-seeking process; and (4) family circumstances were identified. Findings highlight avenues for improving access to child mental health services, including increased provision that is free to service users and flexible to their needs, with opportunities to develop trusting, supportive relationships with professionals. Furthermore, interventions are required to improve parents’ identification of mental health problems, reduce stigma for parents, and increase awareness of how to access services

Evidence generation and reproducibility in cell and gene therapy research: A call to action.

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