Über Complication spinaler Kinderlähmung mit progressiver Muskelatrophie

vorgel. von August FilbryZugl.: Kiel, Univ., Diss., 189

Impact of a pH 5 Oil-in-Water Emulsion on Skin Surface pH

Background: Human skin surface has a physiologically acidic pH (pH ss). In cases of increased pH ss, the acidity of the skin can be restored by topical formulations. We tested a pH 5 oil-in-water (O/W) emulsion for pH ss regeneration and stabilization. Methods: We performed 2 experiments with 10 female study subjects in each. In both experiments, 2D imaging with luminescent sensor foils was used to determine pH ss. Alkalization was reached by washing the volar forearm with a soap bar and warm running tap water for 20 min. Experiment 1: after defining the baseline pH ss, we alkalized the respective area and measured pH ss over a duration of 5 h, while applying emulsion every hour. Experiment 2: study subjects used the emulsion twice daily for 1 week. Then, pH ss was measured before and after 5 min of washing a treated and an untreated area on the volar forearm. Results: (1) 5 h after alkalization, the treated arm showed a significantly lower pH ss than the untreated one (5.87 +/- 0.03 vs. 6.05 +/- 0.03); (2) after washing, the treated area had a significantly lower pH ss than controls (6.13 +/- 0.03 vs. 6.27 +/- 0.05). Conclusions: The tested pH 5 O/W emulsion seems to improve regeneration and stabilization of pH ss. (C) 2017 The Author(s) Published by S. Karger AG, Base

Highly efficient and compatible shampoo for use after hair transplant

Dorothea Schweiger,1 Andrea M Schoelermann,1 Alexander Filbry,1 Tina Hamann,1 Claudia Moser,2 Frank Rippke1 1Research and Development, Beiersdorf AG, Hamburg, Germany; 2Moser Medical, Clinics for Aesthetic Plastic Surgery, Vienna, Austria Background: Sensitive or hyperreactive skin is a common condition defined by prickling, burning, pain, and pruritus. Although this skin problem was initially described on the face, the scalp is often affected. A sensitive scalp can react with irritation to harsh surfactants or other additives which are often present in shampoos. For this reason, we developed a new rinse-off hypertolerant shampoo specifically designed for the hypersensitive and problematic scalp.Methods: The shampoo formulation is based on an extremely mild surfactant system and contains bisabolol, an anti-irritant and anti-inflammatory ingredient of chamomile. The shampoo is free of additives such as perfumes, silicones, colorants, parabens, paraffins, and betaine. Since skin can remain in a hyperreactive state after wounding, the status after hair transplantation was chosen as a model system to test the shampoo. Scalp condition and compatibility of each volunteer were analyzed by a plastic surgeon directly after hair transplant and after stitch removal. The plastic surgeons also rated whether they would recommend the further use of the test shampoo. Additionally, volunteers completed a self-assessment questionnaire.Results: Following hair transplantation, regular use of the shampoo resulted in a significant reduction in the extent of scabbing and erythema. This was confirmed by dermatological scalp examinations performed by the plastic surgeon as well as in volunteers' self-assessments. The plastic surgeon highly recommended the further use of the test shampoo after hair transplant to all study participants.Conclusion: Application of the test shampoo demonstrated excellent skin compatibility and product efficacy after hair transplant. The test shampoo significantly reduced the extent of scabs and erythema. Therefore, the shampoo is ideally suited for use after hair transplantation and for the treatment of sensitive scalp. The excellent skin compatibility is because of the mild surfactant system, the calming ingredient bisabolol, and the absence of potentially irritating ingredients.Keywords: sensitive, scalp, shampoo, bisabolol, hair transplan