1 research outputs found
Evaluation of some systemic inflammatory biomarkers in canine malignant mammary tumors
The aim of this study is to investigate whether neutrophil-to-lymphocyte ratio (NLR),
lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic
immune-inflammation index (SII), albumin-to-globulin ratio (AGR), and prognostic
nutritional index (PNI) parameters could be used as biomarkers for canine malignant
mammary tumors (MMTs), and the changes in these parameters according to different
tumor (T), lymph node (N), and metastasis (M) stages (TNM I-II-III, TNM IV, TNM V)
and the number of affected mammary glands (single, multiple). Thirty-seven with MMT
and 20 healthy dogs were used in this study. Complete blood count and biochemistry
analysis were performed in all dogs. Tumor material is removed by tru-cut and sent to
the pathology laboratory for diagnosis. NLR, PLR, and SII values increased, and LMR
and PNI values decreased in dogs with MMT. Median NLR values increased and median
LMR and PNI values decreased as the TNM stage progressed. In dogs with a single
MMT, median NLR, and PLR values were found to be lower than in dogs with multiple
MMTs, and median LMR, SII, AGR, and PNI values were higher. The present results
indicated that NLR, LMR, PLR, SII, and PNI parameters could be used as biomarkers
for canine MMT. Also, NLR, LMR, PLR, SII, PNI, and AGR parameters may be valuable
biomarkers that reveal the degree of systemic immune response according to different
TNM stages and the number of affected mammary glands