Evidence for X-Linkage in the Transmission of Manic-Depressive Illness

Seven families were found in which manic-depressive illness and either protan or deutan color blindness (X-linked recessive traits) occurred in successive generations. In these seven families, as well as in two others previously reported in the literature, detailed analysis suggests that the genetic loci for manic-depressive illness and the two kinds of colorblindness may be located on the same chromosome. A dominant X-linked gene may thus be involved in the pathogenesis of manic-depressive illness. © 1972, American Medical Association. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Assortative mating in affective disorders

Assortative mating was determined in 170 spouses of patients with major affective illness (bipolar and unipolar). An increase in affective disorders was found in both wives of affected men and husbands of affected women. The data suggest that assortative mating is present in the familial transmission of affective disorder. © 1981.SCOPUS: ar.jinfo:eu-repo/semantics/publishe