Medium-term prognosis of an incident cohort of parkinsonian patients compared to controls

Funding This work was supported by Parkinson's UK (grant numbers G0502, G0914), BMA Doris Hillier Award, the BUPA Foundation, NHS Grampian Endowments, RS MacDonald Trust.Peer reviewedPublisher PD

Building capacity for evidence-based public health: Reconciling the pulls of practice and the push of research

Timely implementation of principles of evidence-based public health (EBPH) is critical for bridging the gap between discovery of new knowledge and its application. Public health organizations need sufficient capacity (the availability of resources, structures, and workforce to plan, deliver, and evaluate the preventive dose of an evidence-based intervention) to move science to practice. We review principles of EBPH, the importance of capacity building to advance evidence-based approaches, promising approaches for capacity building, and future areas for research and practice. Although there is general agreement among practitioners and scientists on the importance of EBPH, there is less clarity on the definition of evidence, how to find it, and how, when, and where to use it. Capacity for EBPH is needed among both individuals and organizations. Capacity can be strengthened via training, use of tools, technical assistance, assessment and feedback, peer networking, and incentives. Modest investments in EBPH capacity building will foster more effective public health practice

Reporting and dealing with missing quality of life data in RCTs : has the picture changed in the last decade?

Peer reviewedPublisher PD

Defamation in Political Radio Broadcasts: More Grist for the Mill

Lamb v. Sutton, 164 F.Supp. 928 (M. D. Tenn 1958)

Crafting a rich and personal blending learning environment: an institutional case study from a STEM perspective

Institutional pressures to make optimal use of lecture halls and classrooms can be powerful motivators to identify resources to develop technology enhanced learning approaches to traditional curricula. From the academic’s perspective, engaging students in active learning and reducing the academic workload are important and complementary drivers. This paper presents a case study of a curriculum development exercise undertaken in a STEM subject area at a research-intensive UK university. A multi-skilled team of academics and learning designers have worked collaboratively to build this module which will be realised as a mix of online and face to face activities. Since the module addresses professional issues, a strong emphasis is being placed on establishing authentic learning activities and realistic use of prominent social tools.The learning designers are working for a cross-institutional initiative to support educational innovations; therefore it is important to carefully document the development process and to identify reusable design patterns which can be easily explained to other academics.<br/

Comparative analysis of human coronavirus-NL63 ORF3 protein homologues

It has been reported in some studies that the newly discovered human coronavirus NL-63 (HCoVNL63) is one of the most common coronaviruses associated with acute respiratory infections. HCoVNL63 was first isolated in 2004 from a 7 month old infant in Holland. The HCoV-NL63 genome encodes for one accessory protein, ORF3. This reports the computational analysis of human coronavirus NL63 ORF3 by comparing the amino acid sequences of coronavirus ORF3-homologues. The HCoV-NL63 ORF3 gene was found to encode a putative protein ~25.6 kDa in size. ORF3 was predicted to contain three potential transmembrane regions. The amino acid sequence of HCoVNL63 ORF3 was shown to be most similar to HCoV 229E ORF4 (43% identity; 62% similarity).Web of Scienc

The role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus Pathogenesis

A respiratory disease caused by a novel coronavirus, termed the severe acute respiratory syndrome coronavirus (SARS-CoV), was first reported in China in late 2002. The subsequent efficient human-to-human transmission of this virus eventually affected more than 30 countries worldwide, resulting in a mortality rate of ~10% of infected individuals. The spread of the virus was ultimately controlled by isolation of infected individuals and there has been no infections reported since April 2004. However, the natural reservoir of the virus was never identified and it is not known if this virus will re-emerge and, therefore, research on this virus continues. The SARS-CoV genome is about 30 kb in length and is predicted to contain 14 functional open reading frames (ORFs). The genome encodes for proteins that are homologous to known coronavirus proteins, such as the replicase proteins (ORFs 1a and 1b) and the four major structural proteins: nucleocapsid (N), spike (S), membrane (M) and envelope (E). SARS-CoV also encodes for eight unique proteins, called accessory proteins, with no known homologues. This review will summarize the current knowledge on SARS-CoV accessory proteins and will include: (i) expression and processing; (ii) the effects on cellular processes; and (iii) functional studies.Web of Scienc

The characterization and phylogenetic relationship of the trichoplusia ni single capsid nuclear polyhedrosis virus polyhedrin gene

The polyhedrin gene (polh) was identified from the Trichoplusia ni (Tni) single capsid nuclear polyhedrosis virus (SNPV). An EcoRI fragment containing the truncated polyhedrin gene was detected by hybridization with an AcMNPV expression vector probe; the remaining portion of the gene was amplified by reverse PCR. An open reading frame (ORF) of 741 nucleotides (nt), encoding a putative protein of 246 amino acids (a.a) with Mr 28,780 Da was identified. The 50-noncoding region contained the putative late (TAAG) transcription initiation motif. The 30 end, downstream of the translation stop codon, lacked an obvious putative poly (A) signal. Nucleotide and amino acid homology are greater than 80% to that of Mamestra brassicae polyhedrin sequences.Results suggest that T. niSNPV is a member of the group II nuclear polyhedrosis viruses.IS

Test of G. E. Type H, Transformer

Citation: Blachly, C. Paul, Fielding and Lathrop Weaver. Test of G. E. Type H, Transformer. Senior thesis, Kansas State Agricultural College, 1905.Morse Department of Special CollectionsIntroduction: Alternating current phenomena are at the present time approaching a stage of development which, when reached, may be considered the master means for the control of power and illumination. Since a great part of the water power in the United States is being utilized by the engineer and converted into electrical energy and transmitted at high voltages to distant cities. Herein lies the use of the alternating current transformer. A static transformer is a continuous laminated iron core interlinked with two electrical circuits, one of which receives electrical energy and the other delivers electrical energy. Fig. 2, Plate H. represents a simple transformer. The coil which receives the electrical energy or that one over which the E.M.F. is first impressed is called the primary, and that coil which delivers electrical energy is called the secondary. Fig.'s 3 and 4, Plate H. represent diagrammatically the core and shell types respectively. If the electric circuits surround the magnetic circuit as in (3) the transformer is said to be of the core type. If the reverse is true as in (4) it is of the shell type. The ratio of transformation is designated by the ratio of the number of turns in the secondary winding to the number in the primary winding. If this ratio is greater than unity the transformer steps up the voltage, and if less than unity steps down the voltage. The one extensive use of the transformer lies in the fact that electrical energy may be taken into the primary winding and delivered from the secondary at a different pressure