Legitimacy of Fan Fiction

The process began began by exploring different possible topics related to the class theme of remix culture . From there I met with Professor Biswas and formulated a strong thesis for my argument. Then I found sources applicable to my topic. I next constructed an outline, created a rough draft, had my draft peer edited by fellow students and Professor Biswas, and finally made appropriate revisions

Coding DNA into Music: An Alternate Way of Analysis

In the study, we are analyzing the human genome in order to determine patterns that may tell something about how DNA functions. Patterns require an explanation: it is highly improbable that they are random occurrence. These patterns may hint to something about how DNA functions. There are known patterns already discovered in DNA. For example, in the coding portion, three base pairs translate to a specific amino acid. In the non coding portion, however, specific patterns are not as simple. We will search for patterns by applying a coding system that turns DNA into music. Music may serve as a powerful tool because we will be able to use to analyze long codings in a short period of time, and the entire phrases will connect in some way. When you listen to a song the order of the chords and phrases have an impact on the entire sound. DNA is the same way; the individual sequencing tie in together to replicate and transcript our genetic material. We will use known knowledge of DNA to base our system of musical coding off of, such as the individual nucleotide sequencing, amino acid coding and protein binding sites. Specific musical assignments will be given to each of the pairings. For example, an adenine base pair could be assigned a C major chord. The DNA will then be played using a computer programing software. The DNA sequences will then be heard and analyzed for specific patterns

Aktualität des Mittelalters und der Renaissance in der Romanistik. Akten der Tagung vom 13.-14. Oktober 2006 in Trier, hg. Lidia Becker

Der hier vorzustellende Band eröffnet zum einen die Schriftenreihe Mittelalter und Renaissance in der Romania, in deren Rahmen die Forschungsergebnisse des gleichnamigen wissenschaftlichen Netzwerks vorgestellt werden sollen, zum anderen enthält er das Ergebnis der ersten Tagung dieses Netzwerks, deren Motto für den Band auch titelgebend geworden ist. Den Beiträgen u. a. aus den Bereichen Sprach-, Literatur- und Kulturwissenschaft sind ein kurzes «Vorwort der Reihenherausgeber » (p. 5) sowie ..

Paul Videsott. Padania scrittologica. Analisi scrittologiche e scrittometriche di testi in italiano settentrionale antico dalle origini al 1525.

Il presente volume, versione rimaneggiata e tradotta della Habilitationsschrift dell’autore,1 mira a “delineare l’evoluzione della lingua scritta volgare non letteraria dell’Italia settentrionale” (7), adoperando un metodo sviluppato, e variamente applica- to, soprattutto da Hans Goebl. L’opera si divide in quattro capitoli, preceduti da due prefazioni (1-6)2 e seguiti dalla “Bibliografia” (423-454), dalle “Cartine coropletiche” (455-620), e da due indici (621-624)

Aktualität des Mittelalters und der Renaissance in der Romanistik. Akten der Tagung vom 13.-14. Oktober 2006 in Trier, hg. Lidia Becker

Der hier vorzustellende Band eröffnet zum einen die Schriftenreihe Mittelalter und Renaissance in der Romania, in deren Rahmen die Forschungsergebnisse des gleichnamigen wissenschaftlichen Netzwerks vorgestellt werden sollen, zum anderen enthält er das Ergebnis der ersten Tagung dieses Netzwerks, deren Motto für den Band auch titelgebend geworden ist. Den Beiträgen u. a. aus den Bereichen Sprach-, Literatur- und Kulturwissenschaft sind ein kurzes «Vorwort der Reihenherausgeber » (p. 5) sowie ..

Phraseology and Stylistics of Literary Language: interdisciplinary approaches / Phraséologie et stylistique de la langue littéraire: approches interdisciplinaires

International audienc

FORMULATION, CHARACTERIZATION, AND IN VIVO EVALUATION OF A FIRST-IN-KIND POLYMER LUNG SURFACTANT THERAPY

The recent COVID-19 pandemic has emphasized the risk of respiratory infections leading to acute respiratory distress syndrome (ARDS). A significant factor contributing to poor ARDS outcomes is the impairment of lung surfactant due to infiltrating surface-active proteins and phospholipases during lung inflammation. Lung surfactant's vital role in stabilizing alveoli by reducing air-water interfacial tension becomes evident as its dysfunction severely compromises respiratory function. Although lung surfactant (LS) replacement therapy effectively addresses neonatal LS deficiencies, its efficacy in ARDS treatment for adults remains limited. The challenge lies in the chemical similarity between current animal-extracted surfactants and human lung surfactant which are both phospholipid-based. To address this issue, this dissertation outlines a transformative "polymer lung surfactant (PLS)" designed to overcome the limitations of conventional exogenous surfactants in treating ARDS.Firstly, a formulation method, referred to as equilibration-nanoprecipitation (ENP), is established which achieves reproducibility, controls sizing, and limits dispersity of the PLS formulation consisting of block copolymer (BCP) kinetically "frozen" micelles/nanoparticles suspended in water. The method uses a two-step approach of 1) equilibrating the BCP nanoparticles in a water/co-solvent mixture and 2) removing co-solvent using dialysis against a large water reservoir. Comparison of ENP with a conventional solvent-exchange technique through experimental and computational analysis yields further insights into ENP's advantages.Next, various studies are highlighted which provide fundamental characterizations of the air-water surface behavior and physical properties of BCP nanoparticles in water. The air-water surface properties of block copolymers have been studied extensively when spread as free chains in organic solvent; however, little was previously known about air-water interfacial behavior of water-spread polymer nanoparticles. The studies address such topics as the effect of nanoparticle size, effect of nanoparticle core chemistry, and the effect of temperature on surface-mechanical behavior. Insights into nanoparticle molecular structure at the interface are provided through X-ray reflectivity and grazing incidence X-ray diffraction. The effect of temperature is further characterized by developing novel NMR and Langmuir trough methods to determine the physical state (glassy vs rubbery) of the core domain in the nanoconfined state at temperatures above and below physiologic temperature.Lastly, in vivo studies are presented which demonstrate the detailed and promising proof-of-concept results on the efficacy of the PLS technology in mouse models of lung injury. The PLS therapy not only improves biomechanical function of the lung, but it also significantly lowers the extent of lung injury as shown by histological analysis and inflammatory marker measurements. An additional in vivo study is presented which highlights challenges in the delivery of the liquid PLS suspension to the lungs. The in vivo studies ultimately provide solid motivation for continued research into the development of the PLS therapy.Given the promising potential of the PLS technology shown in the in vivo studies, the materials characterizations shared in this presentation offer valuable insights into the design of a novel PLS therapy. From these insights, key design parameters such as nanoparticle size characteristics, core chemistry, and core molecular weight can be chosen to produce the most desirable material properties. Overall, this dissertation furthers the progress of PLS therapeutic development and will hopefully ultimately contribute to improved health outcomes in patients suffering from ARDS.</p