Efficiency of turbulent mixing in the abyssal ocean circulation

Turbulent mixing produced by breaking of internal waves plays an important role in setting the patterns of downwelling and upwelling of deep dense waters and thereby helps sustain the global deep ocean overturning circulation. A key parameter used to characterize turbulent mixing is its efficiency, defined here as the fraction of the energy available to turbulence that is invested in mixing. Efficiency is conventionally approximated by a constant value near one sixth. Here we show that efficiency varies significantly in the abyssal ocean and can be as large as approximately one third in density stratified regions near topographic features. Our results indicate that variations in efficiency exert a first-order control over the rate of overturning of the lower branch of the meridional overturning circulation.EPSRC Programme grant EP/K034529/1 entitled “Mathematical Underpinnings of Stratified Turbulence.

Neutron Stars in Teleparallel Gravity

In this paper we deal with neutron stars, which are described by a perfect fluid model, in the context of the teleparallel equivalent of general relativity. We use numerical simulations to find the relationship between the angular momentum of the field and the angular momentum of the source. Such a relation was established for each stable star reached by the numerical simulation once the code is fed with an equation of state, the central energy density and the ratio between polar and equatorial radii. We also find a regime where linear relation between gravitational angular momentum and moment of inertia (as well as angular velocity of the fluid) is valid. We give the spatial distribution of the gravitational energy and show that it has a linear dependence with the squared angular velocity of the source.Comment: 19 pages, 14 figures. arXiv admin note: text overlap with arXiv:1206.331

A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era

Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on “blastomas,” which variably recapitulate the morphologic maturation of organs from which they originate

Functional Characterization of the Plasmodium falciparum Chloroquine-Resistance Transporter (PfCRT) in Transformed Dictyostelium discoideum Vesicles

Chloroquine (CQ)-resistant Plasmodium falciparum malaria has been a global health catastrophe, yet much about the CQ resistance (CQR) mechanism remains unclear. Hallmarks of the CQR phenotype include reduced accumulation of protonated CQ as a weak base in the digestive vacuole of the erythrocyte-stage parasite, and chemosensitization of CQ-resistant (but not CQ-sensitive) P. falciparum by agents such as verapamil. Mutations in the P. falciparum CQR transporter (PfCRT) confer CQR; particularly important among these mutations is the charge-loss substitution K→T at position 76. Dictyostelium discoideum transformed with mutant PfCRT expresses key features of CQR including reduced drug accumulation and verapamil chemosensitization.We describe the isolation and characterization of PfCRT-transformed, hematin-free vesicles from D. discoideum cells. These vesicles permit assessments of drug accumulation, pH, and membrane potential that are difficult or impossible with hematin-containing digestive vacuoles from P. falciparum-infected erythrocytes. Mutant PfCRT-transformed D. discoideum vesicles show features of the CQR phenotype, and manipulations of vesicle membrane potential by agents including ionophores produce large changes of CQ accumulation that are dissociated from vesicular pH. PfCRT in its native or mutant form blunts the ability of valinomycin to reduce CQ accumulation in transformed vesicles and decreases the ability of K(+) to reverse membrane potential hyperpolarization caused by valinomycin treatment.Isolated vesicles from mutant-PfCRT-transformed D. discoideum exhibit features of the CQR phenotype, consistent with evidence that the drug resistance mechanism operates at the P. falciparum digestive vacuole membrane in malaria. Membrane potential apart from pH has a major effect on the PfCRT-mediated CQR phenotype of D. discoideum vesicles. These results support a model of PfCRT as an electrochemical potential-driven transporter in the drug/metabolite superfamily that (appropriately mutated) acts as a saturable simple carrier for the facilitated diffusion of protonated CQ

Feynman Rules for the Rational Part of the Standard Model One-loop Amplitudes in the 't Hooft-Veltman γ5\gamma_5 Scheme

We study Feynman rules for the rational part $R$ of the Standard Model amplitudes at one-loop level in the 't Hooft-Veltman $\gamma_5$ scheme. Comparing our results for quantum chromodynamics and electroweak 1-loop amplitudes with that obtained based on the Kreimer-Korner-Schilcher (KKS) $\gamma_5$ scheme, we find the latter result can be recovered when our $\gamma_5$ scheme becomes identical (by setting $g5s=1$ in our expressions) with the KKS scheme. As an independent check, we also calculate Feynman rules obtained in the KKS scheme, finding our results in complete agreement with formulae presented in the literature. Our results, which are studied in two different $\gamma_5$ schemes, may be useful for clarifying the $\gamma_5$ problem in dimensional regularization. They are helpful to eliminate or find ambiguities arising from different dimensional regularization schemes.Comment: Version published in JHEP, presentation improved, 41 pages, 10 figure

Unitarity Triangle global fits beyond the Standard Model: UTfit 2021 new physics update

Flavour physics represents a unique test bench for the Standard Model (SM). New analyses performed at the LHC experiments are now providing unprecedented insights into CKM metrology and new evidences for rare decays. The CKM picture can provide very precise SM predictions through global analyses. We present here the results of the latest results from UTfit new physics analysis: the Unitarity Triangle (UT) analysis can be used to constrain the parameter space in possible new physics (NP) scenarios. All of the available experimental and theoretical information on ?F = 2 processes is reinterpreted including a model-independent NP parametrisation. We determine the allowed NP contributions in the kaon, D, Bd, and Bs sectors and, in various NP scenarios, we translate them into bounds for the NP scale as a function of NP couplings