Gestión de estructuras de innovación abierta: implementaciones y gestión del Masscapital

[ES] El nuevo paradigma de la gestión de las organizaciones reserva un papel clave a la gestión del Crowdsourcing, y al denominado Masscapital. La gestión de este último elemento es vital en una era nueva donde las denominadas “Estructuras de Innovación Abierta o Masscapital” juegan cada vez un papel más relevante. No obstante, la literatura se ha decantado más por remarcar la relevancia del Crowdsourcing y el denominado Masscapital en la generación de recursos y capacidades a la empresa, que en cómo gestionar su desempeño y desarrollo.Este trabajo se centra en la gestión del Crowdsourcing y el denominado Masscapital dentro de las nuevas concepciones de “Estructuras Organizativas de Innovación Abierta o Masscapital”. Tras remarcar la relevancia del Crowdsourcing y el Masscapital en las organizaciones, y una vez establecidos los elementos esenciales de diseño de estas estructuras el trabajo incide en los elementos clave de gestión de la misma, remarcando elementos importantes en la gestión del Masscapital. El trabajo proporciona ejemplos reales de estas organizaciones en empresas, así como las limitaciones de su uso, gestión y desarrollo práctico.[EN] The new paradigm of organizational management reserves a key role for the management of Crowdsourcing, and the so-called Masscapital. The management of this last element is vital in a new era where the so-called "Open Innovation Structures or Masscapital" play an increasingly relevant role. However, the literature has focused more on the relevance of creowdsourcing and the so-called Masscapital in the generation of resources and capabilities to the company, than on how to manage its performance and development. This paper focuses on the management of Crowdsourcing and Masscapital within the new conceptions of "Open Innovation Organional Structures or Masscapital". After highlighting the relevance of Crowdsourcing and Masscapital in organizations, and once established the essential elements of design of these structures, the work focuses on the key elements of their management, highlighting important elements in the management of Masscapital. The work provides real examples of these organizations in companies, as well as the limitations of their use, management and practical development.Garrigos-Simón, F.; Narangajavana Kaosiri, Y. (2023). Gestión de estructuras de innovación abierta: implementaciones y gestión del Masscapital. Editorial Universitat Politècnica de València. 465-475. https://doi.org/10.4995/INN2022.2022.1650246547

The Influence of Management on Teacher Well-Being and the Development of Sustainable Schools

Teaching is one of the professions with the highest levels of stress and disquiet at work, having a negative impact on teachers’ well-being and performance. Thus, well-being is one of the priorities in human resource management (HRM) in schools. In this regard, this paper studies the relationship between HRM, well-being and performance, observing the incidence of leadership and innovation in these relationships. The objective is to measure the extent to which it is necessary to encourage sustainable environments that promote the well-being of teachers and, by extension, students. The study used the methodology of structural equations and a sample of 315 secondary school teachers. The work validates the influence of leadership by example and information management on HRM and performance. In addition, we confirm the significant effect of human resource management on educational performance. The relationship is observed both directly and through the mediating effect on the improvement of well-being. On the other hand, the positive influence of innovation on performance, both in schools and in the classrooms, is reaffirmed. These results suggest the need to zero in on the human resources policies in schools linked to the improvement of teacher well-being and educational performance. They also highlight the role of school and classroom innovation as a key element in maintaining educational quality

La evolución del concepto de estrategia de marketing internacional y su aplicación al caso español de moda hogar

The export marketing strategy is one of the most important variables among the determinants of the export performance in international companies. This paper pretends to focus on this subject through the analysis of the theoretical concept of marketing and its evolution throughout the last decades, resulting in a change of tendency, which moves from a product based kind of marketing to another based on services. In this context, aspects like relational marketing, corporate social responsibility or the incorporation of new technologies to the operational process will be considered and analyzed from a consistent theoretical background based on the Resource Based View (RBV) and the theory of dynamic capabilities. Additionally, the quantitative analysis of the strategic and operational marketing policies in the home decoration industry in Spain will show, thanks to the testimony of the managers themselves, the way companies carry out their international marketing strategies, giving us the opportunity to identify their strengths and weaknesses in order to contribute to the improvement of the competitive advantage in the industry.La estrategia de marketing internacional es una de las variables más importantes entre los factores que determinan el resultado de una empresa exportadora. Este trabajo pretende profundizar en el tema mediante el análisis del concepto teórico de marketing y su evolución a lo largo de las últimas décadas, resultando en un cambio de tendencia que avanza desde un tipo de marketing centrado en el producto a otro centrado en los servicios. De esta forma, se van a considerar aspectos como el marketing relacional, la responsabilidad social corporativa o la incorporación de las nuevas tecnologías al proceso operativo, que serán analizados desde un trasfondo teórico basado en el punto de vista de los recursos de la empresa (RBV) y la teoría de las capacidades dinámicas. Por otra parte, el análisis cuantitativo de las políticas de marketing estratégico y operativo en el sector de la moda hogar en España mostrará, gracias a los testimonios de los propios directivos, la forma en la que las empresas llevan a cabo sus estrategias de marketing internacional, identificando los puntos fuertes y débiles para contribuir a la mejora de la competitividad empresarial del sector

Social capital, human capital, and sustainability: a bibliometric and visualization analysis

Academic interest in social and human capital is growing significantly. Similarly, their relationship with sustainability is increasing, especially compared to sustainability’s relationship with natural capital and financial and economic capital. Bibliometric and visualization research on these relationships is nonetheless insufficient. This study analyzes the evolution of the literature on natural capital, financial and economic capital, and social and human capital related to sustainability. On the other hand, the study presents a bibliometric analysis on social capital and human capital (SHC) related to sustainability. The article studies 635 references collected from the Web of Science (WoS) Core Collection database and utilizes visualization of similarities (VOS) viewer program to graphically map the material. The analysis involves co-occurrence of keywords, co-citation, and co-authorship. The results reveal not only the state of the art and the leading trends, but also the evolution regarding impact, main journals, documents, topics, authors, institutions, and countries. The study provides researchers and practitioners with a visual and schematic frame of the research on this topic

Quality in Tourism Literature: A Bibliometric Review

[EN] The literature about quality has experienced an important expansion in the tourism sector in the last decade. This is a result of the importance of quality issues when attempting to maintain and expand sustainable business models for tourism organizations and destinations, which are critical to strengthen competitiveness in the new framework. This relevance has been reflected in the tourism literature, with numerous papers focusing on the topic of quality. Nevertheless, despite its importance, there is a lack of studies and reviews of this literature. In order to overcome this problem, this paper develops a bibliometric and visualization analysis of the literature that examines the topics of tourism and quality together. Specifically, the article studies the 4625 documents on this issue published until the end of 2018 in the Web of Science Core Collection database, by using the co-occurrence of keywords, co-citation, bibliographic coupling, and co-authorship analyses. In addition, the VOSviewer program was used to map the diverse clusters or relationships among the literature. The results showed the trends and impact of this literature, and also the main papers, authors, journals, institutions, and even countries that focus on tourism and quality aspects together. They are useful for researchers and practitioners when dealing with this topic, in order to better understand the situation of this issue and its development.This research was funded by Universitat Politecnica de Valencia, Universitat Jaume I. and The APC was funded by Walailak University.Garrigós Simón, FJ.; Narangajavana-Kaosiri, Y.; Narangajavana, Y. (2019). Quality in Tourism Literature: A Bibliometric Review. Sustainability. 11(14):1-22. https://doi.org/10.3390/su11143859S1221114Armenski, T., Dwyer, L., & Pavluković, V. (2017). Destination Competitiveness: Public and Private Sector Tourism Management in Serbia. Journal of Travel Research, 57(3), 384-398. doi:10.1177/0047287517692445Broadus, R. N. (1987). Toward a definition of «bibliometrics». Scientometrics, 12(5-6), 373-379. doi:10.1007/bf02016680Garrigos-Simon, F., Narangajavana-Kaosiri, Y., & Lengua-Lengua, I. (2018). Tourism and Sustainability: A Bibliometric and Visualization Analysis. Sustainability, 10(6), 1976. doi:10.3390/su10061976Michael Hall, C. (2011). Publish and perish? Bibliometric analysis, journal ranking and the assessment of research quality in tourism. Tourism Management, 32(1), 16-27. doi:10.1016/j.tourman.2010.07.001Benckendorff, P., & Zehrer, A. (2013). A NETWORK ANALYSIS OF TOURISM RESEARCH. Annals of Tourism Research, 43, 121-149. doi:10.1016/j.annals.2013.04.005Yuan, Y., Gretzel, U., & Tseng, Y.-H. (2014). Revealing the Nature of Contemporary Tourism Research: Extracting Common Subject Areas through Bibliographic Coupling. International Journal of Tourism Research, 17(5), 417-431. doi:10.1002/jtr.2004Barrios, M., Borrego, A., Vilaginés, A., Ollé, C., & Somoza, M. (2008). A bibliometric study of psychological research on tourism. Scientometrics, 77(3), 453-467. doi:10.1007/s11192-007-1952-0De la Hoz-Correa, A., Muñoz-Leiva, F., & Bakucz, M. (2018). Past themes and future trends in medical tourism research: A co-word analysis. Tourism Management, 65, 200-211. doi:10.1016/j.tourman.2017.10.001García-Lillo, F., Claver-Cortés, E., Úbeda-García, M., Marco-Lajara, B., & Zaragoza-Sáez, P. C. (2018). Mapping the «intellectual structure» of research on human resources in the «tourism and hospitality management scientific domain». International Journal of Contemporary Hospitality Management, 30(3), 1741-1768. doi:10.1108/ijchm-04-2017-0187Buhalis, D. (2000). Marketing the competitive destination of the future. Tourism Management, 21(1), 97-116. doi:10.1016/s0261-5177(99)00095-3Hoegh-Guldberg, O., Mumby, P. J., Hooten, A. J., Steneck, R. S., Greenfield, P., Gomez, E., … Hatziolos, M. E. (2007). Coral Reefs Under Rapid Climate Change and Ocean Acidification. Science, 318(5857), 1737-1742. doi:10.1126/science.1152509Baker, D. A., & Crompton, J. L. (2000). Quality, satisfaction and behavioral intentions. Annals of Tourism Research, 27(3), 785-804. doi:10.1016/s0160-7383(99)00108-5Bigné, J. E., Sánchez, M. I., & Sánchez, J. (2001). Tourism image, evaluation variables and after purchase behaviour: inter-relationship. Tourism Management, 22(6), 607-616. doi:10.1016/s0261-5177(01)00035-8Parasuraman, A., Zeithaml, V. A., & Berry, L. L. (1985). A Conceptual Model of Service Quality and Its Implications for Future Research. Journal of Marketing, 49(4), 41-50. doi:10.1177/002224298504900403Reeves, C. A., & Bednar, D. A. (1994). DEFINING QUALITY: ALTERNATIVES AND IMPLICATIONS. Academy of Management Review, 19(3), 419-445. doi:10.5465/amr.1994.9412271805Kandampully, J. (2000). The impact of demand fluctuation on the quality of service: a tourism industry example. Managing Service Quality: An International Journal, 10(1), 10-19. doi:10.1108/09604520010307012“Quality”http://sdt.unwto.org/en/content/qualityUysal, M., Sirgy, M. J., Woo, E., & Kim, H. (Lina). (2016). Quality of life (QOL) and well-being research in tourism. Tourism Management, 53, 244-261. doi:10.1016/j.tourman.2015.07.013Garrigós-Simón, F. J., Galdón-Salvador, J. L., & Gil-Pechuán, I. (2015). The Economic Sustainability of Tourism Growth through Leakage Calculation. Tourism Economics, 21(4), 721-739. doi:10.5367/te.2014.0372Honarpour, A., Jusoh, A., & Md Nor, K. (2017). Total quality management, knowledge management, and innovation: an empirical study in R&D units. Total Quality Management & Business Excellence, 29(7-8), 798-816. doi:10.1080/14783363.2016.1238760Prayag, G. (2009). TOURISTS’ EVALUATIONS OF DESTINATION IMAGE, SATISFACTION, AND FUTURE BEHAVIORAL INTENTIONS—THE CASE OF MAURITIUS. Journal of Travel & Tourism Marketing, 26(8), 836-853. doi:10.1080/10548400903358729Zeithaml, V. A., Berry, L. L., & Parasuraman, A. (1996). The Behavioral Consequences of Service Quality. Journal of Marketing, 60(2), 31. doi:10.2307/1251929Lynn Shostack, G. (1982). How to Design a Service. European Journal of Marketing, 16(1), 49-63. doi:10.1108/eum0000000004799Crompton, J. L., & Love, L. L. (1995). The Predictive Validity of Alternative Approaches to Evaluating Quality of a Festival. Journal of Travel Research, 34(1), 11-24. doi:10.1177/004728759503400102Wu, H.-C., Li, M.-Y., & Li, T. (2014). A Study of Experiential Quality, Experiential Value, Experiential Satisfaction, Theme Park Image, and Revisit Intention. Journal of Hospitality & Tourism Research, 42(1), 26-73. doi:10.1177/1096348014563396Atilgan, E., Akinci, S., & Aksoy, S. (2003). Mapping service quality in the tourism industry. Managing Service Quality: An International Journal, 13(5), 412-422. doi:10.1108/09604520310495877Merigó, J. M., & Yang, J.-B. (2016). Accounting Research: A Bibliometric Analysis. Australian Accounting Review, 27(1), 71-100. doi:10.1111/auar.12109Delgado López-Cózar, E., Robinson-García, N., & Torres-Salinas, D. (2013). The Google scholar experiment: How to index false papers and manipulate bibliometric indicators. Journal of the Association for Information Science and Technology, 65(3), 446-454. doi:10.1002/asi.23056Cancino, C., Merigó, J. M., Coronado, F., Dessouky, Y., & Dessouky, M. (2017). Forty years of Computers & Industrial Engineering: A bibliometric analysis. Computers & Industrial Engineering, 113, 614-629. doi:10.1016/j.cie.2017.08.033Blanco-Mesa, F., Merigó, J. M., & Gil-Lafuente, A. M. (2017). Fuzzy decision making: A bibliometric-based review. Journal of Intelligent & Fuzzy Systems, 32(3), 2033-2050. doi:10.3233/jifs-161640Merigó, J. M., Gil-Lafuente, A. M., & Yager, R. R. (2015). An overview of fuzzy research with bibliometric indicators. Applied Soft Computing, 27, 420-433. doi:10.1016/j.asoc.2014.10.035Hirsch, J. E. (2005). An index to quantify an individual’s scientific research output. Proceedings of the National Academy of Sciences, 102(46), 16569-16572. doi:10.1073/pnas.0507655102Van Eck, N. J., & Waltman, L. (2009). Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 84(2), 523-538. doi:10.1007/s11192-009-0146-3Small, H. (1973). Co-citation in the scientific literature: A new measure of the relationship between two documents. Journal of the American Society for Information Science, 24(4), 265-269. doi:10.1002/asi.4630240406Kessler, M. M. (1963). Bibliographic coupling between scientific papers. American Documentation, 14(1), 10-25. doi:10.1002/asi.5090140103Liao, H., Tang, M., Luo, L., Li, C., Chiclana, F., & Zeng, X.-J. (2018). A Bibliometric Analysis and Visualization of Medical Big Data Research. Sustainability, 10(2), 166. doi:10.3390/su10010166Chen, C.-F., & Chen, F.-S. (2010). Experience quality, perceived value, satisfaction and behavioral intentions for heritage tourists. Tourism Management, 31(1), 29-35. doi:10.1016/j.tourman.2009.02.008Fornell, C., & Larcker, D. F. (1981). Evaluating Structural Equation Models with Unobservable Variables and Measurement Error. Journal of Marketing Research, 18(1), 39-50. doi:10.1177/002224378101800104Yoon, Y., & Uysal, M. (2005). An examination of the effects of motivation and satisfaction on destination loyalty: a structural model. Tourism Management, 26(1), 45-56. doi:10.1016/j.tourman.2003.08.016Zeithaml, V. A. (1988). Consumer Perceptions of Price, Quality, and Value: A Means-End Model and Synthesis of Evidence. Journal of Marketing, 52(3), 2-22. doi:10.1177/002224298805200302Cronin, J. J., Brady, M. K., & Hult, G. T. M. (2000). Assessing the effects of quality, value, and customer satisfaction on consumer behavioral intentions in service environments. Journal of Retailing, 76(2), 193-218. doi:10.1016/s0022-4359(00)00028-2Anderson, J. C., & Gerbing, D. W. (1988). Structural equation modeling in practice: A review and recommended two-step approach. Psychological Bulletin, 103(3), 411-423. doi:10.1037/0033-2909.103.3.411Reyes-Gonzalez, L., Gonzalez-Brambila, C. N., & Veloso, F. (2016). Using co-authorship and citation analysis to identify research groups: a new way to assess performance. Scientometrics, 108(3), 1171-1191. doi:10.1007/s11192-016-2029-8Lai, K., Li, J., & Scott, N. (2015). Tourism problemology: Reflexivity of knowledge making. Annals of Tourism Research, 51, 17-33. doi:10.1016/j.annals.2014.12.00

Connectivity in the set of Tight Frame Wavelets (TFW)

We introduce new ideas to treat the problem of connectivity of wavelets. We develop a method which produces intermediate paths of Tight Frame Wavelets (TFW). Using this method we prove that a large class of TFW-s, with only mild conditions on their spectrum, are arcwise connected

Uso de Twitter en docencia: estudio bibliométrico

[ES] En la presente comunicación se expone el resumen de un estudio bibliométrico realizado sobre el uso de Twitter en la docencia, empleando para ello la base de datos de utilizando la base de datos de la Web of Science, identificando los artículos más relevantes clasificada por artículos, autores, y países.[EN] In thepresentcommunicationthesummary of a bibliometricstudymadeonthe use of Twitter in teachingisexposed, usingforthisthedatabase of usingtheWeb of Sciencedatabase, identifyingthemostrelevantarticlesclassifiedbyarticles, authors, and countries.Oltra Gutiérrez, JV.; Garrigos Simón, F.; Narangajavana, Y.; Montesa Andrés, J. (2019). Uso de Twitter en docencia: estudio bibliométrico. En INNODOCT/18. International Conference on Innovation, Documentation and Education. Editorial Universitat Politècnica de València. 929-938. https://doi.org/10.4995/INN2018.2018.8924OCS92993

Tourism and Sustainability: A Bibliometric and Visualization Analysis

[EN] Sustainability is a growing research topic in tourism due to the importance of environmental and social issues, and the maintenance of patrimony and other facilities to conserve the potential of tourism destinations. Specifically, sustainability in tourism is crucial in order to guarantee a consistent development of destinations, measured by growth in income and employment. This relevance has been translated into an explosive growth in the sustainability literature regarding tourism, income, and employment. However, there is a lack of bibliometric and visualization research on tourism sustainability (TS), and specifically on its relationship with income and employment. This paper aims to present a bibliometric overview of TS research, and specifically TS related to income and employment. The current work analyzed 2279 references collected from the Web of Science (WoS) Core Collection database and used the visualization of similarities (VOS)viewer program to graphically map the material. The study used co-occurrence of keywords, co-citation, bibliographic coupling, and co-authorship analyses. The results identify the development status and the leading trends in terms of impact, main journals, papers, topics, authors, institutions, and countries. The analysis and graphical presentations are relevant, as they can help researchers and practitioners better understand the state of the art of TS.The authors would like to thank Universitat Politecnica de Valencia, for supporting this research.Garrigós Simón, FJ.; Narangajavana-Kaosiri, Y.; Lengua, I. (2018). Tourism and Sustainability: A Bibliometric and Visualization Analysis. Sustainability. 10(6):1-23. https://doi.org/10.3390/su10061976S12310

Characterization of protons accelerated from a 3 TW table-top laser system

[EN] We report on benchmark tests of a 3 TW/50 fs, table-top laser system specifically developed for proton acceleration with an intrinsic pump rate up to 100 Hz. In two series of single-shot measurements differing in pulse energy and contrast the successful operation of the diode pumped laser is demonstrated. Protons have been accelerated up to 1.6 MeV in interactions of laser pulses focused on aluminium and mylar foils between 0.8 and 25 mu m thickness. Their spectral distributions and maximum energies are consistent with former experiments under similar conditions. These results show the suitability of our system and provide a reference for studies of laser targets at high repetition rate and possible applications.This project has been funded by Centro para el Desarrollo Tecnologico Industrial (CDTI, Spain) within the INNPRONTA program, grant no. IPT-20111027, by EUROSTARS project E9113, and by the Spanish Ministry for Economy and Competitiveness within the Retos-Colaboracion 2015 initiative, ref. RTC-2015-3278-1.Bellido-Millán, PJ.; Lera, R.; Seimetz, M.; Ruiz-De La Cruz, A.; Torres Peiró, S.; Galán, M.; Mur, P.... (2017). Characterization of protons accelerated from a 3 TW table-top laser system. Journal of Instrumentation. 12:1-12. https://doi.org/10.1088/1748-0221/12/05/T05001S11212Daido, H., Nishiuchi, M., & Pirozhkov, A. S. (2012). Review of laser-driven ion sources and their applications. Reports on Progress in Physics, 75(5), 056401. doi:10.1088/0034-4885/75/5/056401Macchi, A., Borghesi, M., & Passoni, M. (2013). Ion acceleration by superintense laser-plasma interaction. Reviews of Modern Physics, 85(2), 751-793. doi:10.1103/revmodphys.85.751Ledingham, K., Bolton, P., Shikazono, N., & Ma, C.-M. (2014). Towards Laser Driven Hadron Cancer Radiotherapy: A Review of Progress. Applied Sciences, 4(3), 402-443. doi:10.3390/app4030402Kraft, S. D., Richter, C., Zeil, K., Baumann, M., Beyreuther, E., Bock, S., … Pawelke, J. (2010). Dose-dependent biological damage of tumour cells by laser-accelerated proton beams. New Journal of Physics, 12(8), 085003. doi:10.1088/1367-2630/12/8/085003Yogo, A., Sato, K., Nishikino, M., Mori, M., Teshima, T., Numasaki, H., … Daido, H. (2009). Application of laser-accelerated protons to the demonstration of DNA double-strand breaks in human cancer cells. Applied Physics Letters, 94(18), 181502. doi:10.1063/1.3126452Fritzler, S., Malka, V., Grillon, G., Rousseau, J. P., Burgy, F., Lefebvre, E., … Ledingham, K. W. D. (2003). Proton beams generated with high-intensity lasers: Applications to medical isotope production. Applied Physics Letters, 83(15), 3039-3041. doi:10.1063/1.1616661Kishimura, H., Morishita, H., Okano, Y. H., Okano, Y., Hironaka, Y., Kondo, K., … Nemoto, K. (2004). Enhanced generation of fast protons from a polymer-coated metal foil by a femtosecond intense laser field. Applied Physics Letters, 85(14), 2736-2738. doi:10.1063/1.1803915Nakamura, S., Iwashita, Y., Noda, A., Shirai, T., Tongu, H., Fukumi, A., … Wada, Y. (2006). Real-Time Optimization of Proton Production by Intense Short-Pulse Laser with Time-of-Flight Measurement. Japanese Journal of Applied Physics, 45(No. 34), L913-L916. doi:10.1143/jjap.45.l913Nishiuchi, M., Fukumi, A., Daido, H., Li, Z., Sagisaka, A., Ogura, K., … Nakamura, S. (2006). The laser proton acceleration in the strong charge separation regime. Physics Letters A, 357(4-5), 339-344. doi:10.1016/j.physleta.2006.04.053Yogo, A., Daido, H., Fukumi, A., Li, Z., Ogura, K., Sagisaka, A., … Itoh, A. (2007). Laser prepulse dependency of proton-energy distributions in ultraintense laser-foil interactions with an online time-of-flight technique. Physics of Plasmas, 14(4), 043104. doi:10.1063/1.2721066Robinson, A. P. L., Foster, P., Adams, D., Carroll, D. C., Dromey, B., Hawkes, S., … Neely, D. (2009). Spectral modification of laser-accelerated proton beams by self-generated magnetic fields. New Journal of Physics, 11(8), 083018. doi:10.1088/1367-2630/11/8/083018Nemoto, K., Maksimchuk, A., Banerjee, S., Flippo, K., Mourou, G., Umstadter, D., & Bychenkov, V. Y. (2001). Laser-triggered ion acceleration and table top isotope production. Applied Physics Letters, 78(5), 595-597. doi:10.1063/1.1343845Lee, K., Park, S. H., Cha, Y.-H., Lee, J. Y., Lee, Y. W., Yea, K.-H., & Jeong, Y. U. (2008). Generation of intense proton beams from plastic targets irradiated by an ultraintense laser pulse. Physical Review E, 78(5). doi:10.1103/physreve.78.056403Yogo, A., Daido, H., Bulanov, S. V., Nemoto, K., Oishi, Y., Nayuki, T., … Tajima, T. (2008). Laser ion acceleration via control of the near-critical density target. Physical Review E, 77(1). doi:10.1103/physreve.77.016401Lee, K., Lee, J. Y., Park, S. H., Cha, Y.-H., Lee, Y. W., Kim, K. N., & Jeong, Y. U. (2011). Dominant front-side acceleration of energetic proton beams from plastic targets irradiated by an ultraintense laser pulse. Physics of Plasmas, 18(1), 013101. doi:10.1063/1.3496058OKIHARA, S., SENTOKU, Y., SUEDA, K., SHIMIZU, S., SATO, F., MIYANAGA, N., … SAKABE, S. (2002). Energetic Proton Generation in a Thin Plastic Foil Irradiated by Intense Femtosecond Lasers. Journal of Nuclear Science and Technology, 39(1), 1-5. doi:10.1080/18811248.2002.9715150McKenna, P., Ledingham, K. W. D., Spencer, I., McCany, T., Singhal, R. P., Ziener, C., … Clark, E. L. (2002). Characterization of multiterawatt laser-solid interactions for proton acceleration. Review of Scientific Instruments, 73(12), 4176-4184. doi:10.1063/1.1516855Spencer, I., Ledingham, K. W. D., McKenna, P., McCanny, T., Singhal, R. P., Foster, P. S., … Davies, J. R. (2003). Experimental study of proton emission from 60-fs, 200-mJ high-repetition-rate tabletop-laser pulses interacting with solid targets. Physical Review E, 67(4). doi:10.1103/physreve.67.046402Kaluza, M., Schreiber, J., Santala, M. I. K., Tsakiris, G. D., Eidmann, K., Meyer-ter-Vehn, J., & Witte, K. J. (2004). Influence of the Laser Prepulse on Proton Acceleration in Thin-Foil Experiments. Physical Review Letters, 93(4). doi:10.1103/physrevlett.93.045003Ceccotti, T., Lévy, A., Popescu, H., Réau, F., D’Oliveira, P., Monot, P., … Martin, P. (2007). Proton Acceleration with High-Intensity Ultrahigh-Contrast Laser Pulses. Physical Review Letters, 99(18). doi:10.1103/physrevlett.99.185002Neely, D., Foster, P., Robinson, A., Lindau, F., Lundh, O., Persson, A., … McKenna, P. (2006). Enhanced proton beams from ultrathin targets driven by high contrast laser pulses. Applied Physics Letters, 89(2), 021502. doi:10.1063/1.2220011Steinke, S., Henig, A., Schnürer, M., Sokollik, T., Nickles, P. V., Jung, D., … Habs, D. (2010). Efficient ion acceleration by collective laser-driven electron dynamics with ultra-thin foil targets. Laser and Particle Beams, 28(1), 215-221. doi:10.1017/s0263034610000157Strickland, D., & Mourou, G. (1985). Compression of amplified chirped optical pulses. Optics Communications, 56(3), 219-221. doi:10.1016/0030-4018(85)90120-8Yogo, A., Kondo, K., Mori, M., Kiriyama, H., Ogura, K., Shimomura, T., … Bolton, P. R. (2014). Insertable pulse cleaning module with a saturable absorber pair and a compensating amplifier for high-intensity ultrashort-pulse lasers. Optics Express, 22(2), 2060. doi:10.1364/oe.22.002060Trisorio, A., Grabielle, S., Divall, M., Forget, N., & Hauri, C. P. (2012). Self-referenced spectral interferometry for ultrashort infrared pulse characterization. Optics Letters, 37(14), 2892. doi:10.1364/ol.37.002892Seimetz, M., Bellido, P., Soriano, A., Garcia Lopez, J., Jimenez-Ramos, M. C., Fernandez, B., … Benlloch, J. M. (2015). 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Weak phenotypic reversion of ivermectin resistance in a field resistant isolate of Haemonchus contortus by verapamil

Recent advances in anthelmintic resistant phenotype reversion by Pgp modulating drugs in ruminant nematodes indicate that this can be a useful tool to helminth control. The aim of the present study was to evaluate the efficacy of ivermectin (IVM) in combination with verapamil (VRP), in oil or water-based vehicle, against an IVM-resistant field isolate of Haemonchus contortus through a larval migration assay and experimental infection trial. In the in vitro assay was observed a phenotypic reversion of H. contortus resistance to ivermectin at a high concentration of VRP, increasing IVM efficacy from 53.1% to 94.3. In the in vivo trial, IVM + VRP demonstrated 36.02% efficacy compared to the 7.75% of IVM alone. The vehicle formulation showed no influence in efficacy. These are the first results demonstrating the effect of VRP as a partial IVM-resistance phenotype reverser in a field isolate of IVM-resistant H. contortus experimentally inoculated in sheep