Características clínico-laboratoriales de pacientes con lupus eritematoso sistémico del Hospital Regional Lambayeque 2013-2018

Objetivo: Describir las características clínicas y laboratoriales de lupus eritematoso sistémico en pacientes que acudieron al Hospital Regional Lambayeque durante los años 2013- 2018. Materiales y Métodos: Estudio descriptivo-transversal-retrospectivo. Se evaluaron las historias clínicas de los pacientes con diagnóstico de Lupus Eritematoso Sistémico (LES) diagnosticados en el Hospital Regional Lambayeque durante el periodo 2013-2018. Se utilizó una ficha de recolección de datos basada en los criterios de SLICC 2012; La población diana estuvo conformada por 89 historias clínicas de las cuales 26 estuvieron ausentes en los archivos, siete se excluyeron, quedando 56 historias clínicas para el análisis, el muestreo fue de tipo censal. Resultados: La mediana de la edad fue de 27 años (RIC: 11-74). Fue más frecuente en mujeres que en varones (proporción 6/1). La característica clínica más frecuente fue la nefropatía lúpica (36 pacientes) seguido del lupus cutáneo agudo (25 pacientes). Respecto de los pacientes que contaban biopsia renal (12 personas), el estadio más frecuente fue el IV (9 pacientes). Las alteraciones hematológicas más frecuentes fueron las linfopenias (16/56 pacientes). En el ámbito laboratorial la alteración más frecuente fue la positividad del anticuerpo ANA (52 pacientes). Conclusión: El LES es más frecuente en personas adultas jóvenes del sexo femenino. La nefritis lúpica y el ANA (+), son la característica clínica y laboratorial más frecuentes, respectivamente. Entre las manifestaciones hematológicas más frecuentes están las linfoideas

Radioisotope production at the IFMIF-DONES facility

This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 and 2019-2020 under grant agreement No 633053. The views and opinions expressed herein do not necessarily reflect those of the European Commission. This work was supported by the Spanish projects FIS2015-69941-C2-1-P (MINECO-FEDER, EU), A-FQM-371-UGR18 (Prog. Operativo FEDER Andalucia 2014-2020), the Spanish Association Against Cancer (AECC) (Grant No. PS16163811PORR), and the sponsors of the University of Granada Chair Neutrons for Medicine: Fundacion ACS, Capitan Antonio and La Kuadrilla.The International Fusion Materials Irradiation Facility - Demo Oriented NEutron Source (IFMIF-DONES) is a single-sited novel Research Infrastructure for testing, validation and qualification of the materials to be used in a fusion reactor. Recently, IFMIF-DONES has been declared of interest by ESFRI (European Strategy Forum on Research Infrastructures) and its European host city would be Granada (Spain). In spite the first and most important application of IFMIF-DONES related to fusion technology, the unprecedented neutron flux available could be exploited without modifying the routine operation of IFMIF-DONES. Thus, it is already planned an experimental hall for a complementary program with neutrons. Also, a complementary program on the use of the deuteron beam could help IFMIF-DONES to be more sustainable. In the present work, we study radioisotope production with deuterons of Lu-177. The results show the viability of IFMIF-DONES for such production in terms of the needs of a territory of small-medium size. Also the study suggests that new nuclear data at higher deuteron energies are mandatory for an accurate study in this field.Euratom 633053Spanish project (MINECO-FEDER, EU) FIS2015-69941-C2-1-PSpanish project (Prog. Operativo FEDER Andalucia 2014-2020) A-FQM-371-UGR18Spanish Association Against Cancer (AECC) PS16163811PORRUniversity of Granada Chair Neutrons for Medicine: Fundacion AC

Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications

Inherited retinal diseases (IRDs), defined by dysfunction or progressive loss of photoreceptors, are disorders characterized by elevated heterogeneity, both at the clinical and genetic levels. Our main goal was to address the genetic landscape of IRD in the largest cohort of Spanish patients reported to date. A retrospective hospital-based cross-sectional study was carried out on 6089 IRD affected individuals (from 4403 unrelated families), referred for genetic testing from all the Spanish autonomous communities. Clinical, demographic and familiar data were collected from each patient, including family pedigree, age of appearance of visual symptoms, presence of any systemic findings and geographical origin. Genetic studies were performed to the 3951 families with available DNA using different molecular techniques. Overall, 53.2% (2100/3951) of the studied families were genetically characterized, and 1549 different likely causative variants in 142 genes were identified. The most common phenotype encountered is retinitis pigmentosa (RP) (55.6% of families, 2447/4403). The most recurrently mutated genes were PRPH2, ABCA4 and RS1 in autosomal dominant (AD), autosomal recessive (AR) and X-linked (XL) NON-RP cases, respectively; RHO, USH2A and RPGR in AD, AR and XL for non-syndromic RP; and USH2A and MYO7A in syndromic IRD. Pathogenic variants c.3386G > T (p.Arg1129Leu) in ABCA4 and c.2276G > T (p.Cys759Phe) in USH2A were the most frequent variants identified. Our study provides the general landscape for IRD in Spain, reporting the largest cohort ever presented. Our results have important implications for genetic diagnosis, counselling and new therapeutic strategies to both the Spanish population and other related populations.This work was supported by the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Health (FIS; PI16/00425 and PI19/00321), Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER, 06/07/0036), IIS-FJD BioBank (PT13/0010/0012), Comunidad de Madrid (CAM, RAREGenomics Project, B2017/BMD-3721), European Regional Development Fund (FEDER), the Organización Nacional de Ciegos Españoles (ONCE), Fundación Ramón Areces, Fundación Conchita Rábago and the University Chair UAM-IIS-FJD of Genomic Medicine. Irene Perea-Romero is supported by a PhD fellowship from the predoctoral Program from ISCIII (FI17/00192). Ionut F. Iancu is supported by a grant from the Comunidad de Madrid (CAM, PEJ-2017-AI/BMD7256). Marta del Pozo-Valero is supported by a PhD grant from the Fundación Conchita Rábago. Berta Almoguera is supported by a Juan Rodes program from ISCIII (JR17/00020). Pablo Minguez is supported by a Miguel Servet program from ISCIII (CP16/00116). Marta Corton is supported by a Miguel Servet program from ISCIII (CPII17/00006). The funders played no role in study design, data collection, data analysis, manuscript preparation and/or publication decisions

Global overview of the management of acute cholecystitis during the COVID-19 pandemic (CHOLECOVID study)

Background: This study provides a global overview of the management of patients with acute cholecystitis during the initial phase of the COVID-19 pandemic. Methods: CHOLECOVID is an international, multicentre, observational comparative study of patients admitted to hospital with acute cholecystitis during the COVID-19 pandemic. Data on management were collected for a 2-month study interval coincident with the WHO declaration of the SARS-CoV-2 pandemic and compared with an equivalent pre-pandemic time interval. Mediation analysis examined the influence of SARS-COV-2 infection on 30-day mortality. Results: This study collected data on 9783 patients with acute cholecystitis admitted to 247 hospitals across the world. The pandemic was associated with reduced availability of surgical workforce and operating facilities globally, a significant shift to worse severity of disease, and increased use of conservative management. There was a reduction (both absolute and proportionate) in the number of patients undergoing cholecystectomy from 3095 patients (56.2 per cent) pre-pandemic to 1998 patients (46.2 per cent) during the pandemic but there was no difference in 30-day all-cause mortality after cholecystectomy comparing the pre-pandemic interval with the pandemic (13 patients (0.4 per cent) pre-pandemic to 13 patients (0.6 per cent) pandemic; P = 0.355). In mediation analysis, an admission with acute cholecystitis during the pandemic was associated with a non-significant increased risk of death (OR 1.29, 95 per cent c.i. 0.93 to 1.79, P = 0.121). Conclusion: CHOLECOVID provides a unique overview of the treatment of patients with cholecystitis across the globe during the first months of the SARS-CoV-2 pandemic. The study highlights the need for system resilience in retention of elective surgical activity. Cholecystectomy was associated with a low risk of mortality and deferral of treatment results in an increase in avoidable morbidity that represents the non-COVID cost of this pandemic

Enljoyment through a proposal of active breaks in early childhood education

La siguiente propuesta muestra un estudio que pretendió comprobar cuál es la influencia que tienen los descansos activos en el disfrute del alumnado de Educación Infantil, siendo este un elemento de la motivación. Además, se evaluó la existencia de diferencias en el disfrute en función del sexo del alumnado. Para ello, se llevó a cabo una metodología basada en los descansos activos durante diez días, en los cuales se recogieron las impresiones del alumnado a través de un test que se pasaba tras la actividad sedentaria, y, de igual forma, tras los descansos activos. Igualmente, se recogieron las impresiones por parte del profesorado a través de una entrevista realizada el último día del estudio. La muestra tomada para este trabajo constaba de 22 sujetos de una clase del primer curso del segundo ciclo de Educación Infantil (3 años), siendo estos 12 niñas y 10 niños. Finalmente, los resultados permitieron concluir que los descansos activos aumentan el disfrute del alumnado, sin que se den diferencias de acuerdo con la variable sexoThe following proposal shows a study that attempted to verify the influence that active rests have on the enjoyment of Infant Education students, this being an element of motivation. In addition, the existence of differences in enjoyment according to the sex of the student body was evaluated. To this end, a methodology was carried out based on active breaks during ten days, in which the student’s impressions were collected through a test that was passed after sedentary activity and, in the same way, after active breaks. Likewise, the impressions were collected from the teachers through an interview carried out on the last day of the study. The sample taken for this work consisted of 22 subjects from a class in the first year of the second cycle of Infant Education (3 years), these being 12 girls and 10 boys. Finally, the results allowed us to conclude that active breaks increase the enjoyment of the students, without differences according to the sex variable

Montmorillonite materials with paramagnetic metal complexes: Structural studies and catalytic degradation of emerging pollutants

The aim of this work was to characterize and propose the use of new heterogeneous catalysts based on montmorillonite (Mt) materials bearing organic copper metal complexes to remove a variety of emerging pollutants such as antibiotics, azo dyes and antimycotics. The incorporation of Cu2+ ions and their coordination by 4-methyl-5-imidazolecarboxaldehyde (Im) or 4-acetylpyridine (Py) ligands in the interlayer space of the clay were studied by NMR, XRD, EPR and XPS, which provided information about the surface chemical composition of the copper centers and the ligands present in the materials. The ligands were incorporated into different zones of the Mt-Cu structure, being the Im and Py ligands (L) preferentially located outside and inside the interlayer space, respectively, showing different incorporation degrees. The catalytic activity of the composites (Mt-Cu-L) was demonstrated by their capacity to generate ROS and to degrade pollutants, producing an environmentally non-toxic waste, as assessed by the brine shrimp toxicity assay.Fil: Crespi, Ayelen Florencia. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; ArgentinaFil: Zomero, Paula Natalia. Universidad de Buenos Aires; ArgentinaFil: Pérez, Ana Laura. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Brondino, Carlos Dante. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Infantes Molina, Antonia. Universidad de Málaga; EspañaFil: Garro Linck, Yamila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Fernandez, Mariela Alejandra. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; ArgentinaFil: Rodríguez Castellón, Enrique. Universidad de Málaga. Facultad de Ciencias; EspañaFil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentin