96 research outputs found

    Constitvciones para el buen govierno de el Colegio Seminario de S. Sebastian desta Santa Iglesia Cathedral de Malaga

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    Jose Rodriguez Cornejo es el ed. lit., en el s. XVIII, del texto fechado en 1616.Fechas de actividad del imp.: 1723-1727.Sign: []2, B-G2.Port. con orla tip.; en h. 2r. inic. grab. y banda de adornos tip. en cabecera.e,ir r-ea uee- essi (3)BNE19970001438.Copia digital : Diputación de Málaga. Biblioteca Canovas del Castillo, 201

    Nivel de conocimiento en cirujanos dentistas sobre osteonecrosis de los maxilares inducida por bifosfonatos en el tratamiento odontológico, Chiclayo

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    El objetivo de estudio fue determinar el nivel de conocimiento sobre osteonecrosis de los maxilares relacionados con los bifosfonatos en cirujanos dentistas, Chiclayo. El estudio tiene un enfoque cuantitativo, nivel de investigación descriptivo, diseño observacional y de tipo prospectivo, transversal y descriptivo. La población total fue de 1188 Cirujanos Dentistas registrados en el Colegio Odontológico del Perú, región Lambayeque en donde se realizó un muestreo aleatorio simple y se obtuvo una muestra de 341 cirujanos dentistas. Se creó un cuestionario virtual en el programa Google Forms, que estuvo conformado por 16 preguntas con 5 alternativas de respuesta para evaluar el nivel de conocimiento, con características dicotómicas, calificando desde bajo a alto, donde la puntuación baja era de 0 – 5, medio de 6 – 10 y alto de 11 – 16. Cada una de las respuestas correctas recibió una puntuación de 1; mientras que, una respuesta incorrecta recibió una puntuación de 0. Se encontró a los cirujanos dentistas, el 56.3% tienen un nivel de conocimiento medio sobre osteonecrosis de los maxilares relacionados con los bifosfonatos, el 38.1% tienen nivel alto y el 5.6% tienen nivel bajo

    Spectroscopic studies of photodamage and photoprotection of photosystem II

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    Light is required for photosynthesis to occur, but it also has a deleterious effect by damaging the photosynthetic machinery, in particular Photosystem II (PSII). Photoinhibition of PSII is a complex process, balancing between photoinactivation, protective and repair mechanisms. Current understanding of photodamage is limited to competing hypotheses where the photosensitizer is either photosynthetic pigments or the Mn4CaO5 cluster itself, with little consensus on the mechanisms and consequences of PSII photoinactivation. Using different spectroscopic techniques, the author evaluated the mechanisms of photodamage and photoprotection of PSII under visible light. In the first Chapter a critical examination is presented of current evidence about the photodamage mechanisms, in particular that related to the action spectra of photodamage. The second Chapter examines if the damage to the Mn4CaO5 cluster is applicable to PSII under visible light as manganese absorbs visible light only weakly. The third Chapter was intended to determine which of the three main events of PSII photodamage occurs first: (1) Inactivation of the oxygen evolution; (2) inactivation of the PSII RC; (3) and release of Mn ions. The fourth Chapter evaluates whether quenching of excessive excitation does protect PSII from photodamage, as the recent rise of paradigms that advocate that photodamage is independent of excessive excitation has questioned the relevance of quenching mechanisms. Finally, the fifth Chapter discusses and integrates the result of the present thesis in the context of the current hypothesis to explain PSII photodamage. The main results of this work are: (1) visible light damages Mn4CaO5 cluster prior to photodamage to the PSII reaction center; (2) the two step model under visible light is explained mostly by limitations on the acceptor side; (3) release of Mn ions is not the cause of PSII inactivation but a later consequence; and (4) the discovery of a long-lived fluorescence quencher that accumulates faster than the light-induced loss of PSII efficiency shows that the induction of this quencher is a preventive mechanism to reduce the excitation pressure and not the consequence of photodamage. Upon critical examination of the previously reported evidence and the new discoveries in the present work, the hybrid mechanism of photoinactivation, sensitized mostly by photosynthetic pigments and in minor way the Mn4CaO5, is the most plausible explanation to PSII photodamage under visible light

    Immunity and vaccine development efforts against Trypanosoma cruzi

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    Artículo de revisión especializadoTrypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a critical lack of methods for prevention of infection or treatment of acute infection and chronic disease. Studies in experimental models have suggested that the protective immunity against T. cruzi infection requires the elicitation of Th1 cytokines, lytic antibodies and the concerted activities of macrophages, T helper cells, and cytotoxic T lymphocytes (CTLs). In this review, we summarize the research efforts in vaccine development to date and the challenges faced in achieving an efficient prophylactic or therapeutic vaccine against human CD.UTM
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