GARIS: DESVENDANDO SEU UNIVERSO

Este texto é fruto de uma pesquisa etnográfica, realizada com garis, nacidade de Franca – SP. O instrumento fundamental para a coleta de dados foi a entrevista aprofundada, com a utilização do gravador. Teve como objetivo desvendar aspectos do universo desses trabalhadores, tais como: perfil, constelação familiar, condições de vida e de trabalho, bem como valores e expectativas. A pesquisa revelou, entre outros dados, o quanto o ofício de gari é árduo, desvalorizado pela sociedade, alvo de humilhação, desprezo e discriminação

Revendo o percurso: o rural visto por dentro

This paper addresses the experience gained by the author in the field, between 1980 and 1986, when data were collected with rural workers of Fazenda Primavera (Muniipality of Andradina - SP) for her doctoral research. The text sprung from the desire to narrate what was recorded in her memory and field diary throughout the study. By inspiration on Social Anthropology, fragments, scenes, and oral reports were collected which are indicative of the values that guide those workers' lives and culture. In addition to the findings, emphasis must be given to what was experienced, felt and observed.Este texto trata das vivências de campo da autora, entre 1980 e 1986, por ocasião da coleta de dados com os lavradores da Fazenda Primavera (Município de Andradina - SP), para sua tese de doutorado. O texto nasceu do desejo de narrar o que a memória e o diário de campo registraram, ao longo da caminhada. De inspiração sócio-antropológica, recolheu fragmentos, cenas, falas, reveladores dos valores que norteiam a vida desses camponeses, de sua cultura. Para além do resultado obtido na pesquisa realizada, sobressai-se o que foi vivido, sentido, observado

Convexity and symmetry of central configurations in the five-body problem: Lagrange plus two

We study convexity and symmetry of central configurations in the five body problem when three of the masses ara located at the vertices of an equilateral triangle, that we call Lagrange plus two central configurations. First, we prove that the two bodies out of the vertices of the triangle cannot be placed on certain lines. Next, we give a geometrical characterization of such configurations in the sense as that of Dziobek, and we describe the admissible regions where the two remaining bodies can be placed. Furthermore, we prove that any Lagrange plus two central configuration is concave. Finally, we show numerically the existence of non-symmetric central configurations of the five body problem.First and second authors are supported by MINECO grants MTM2016-80117-P and MTM2016-77278-P (FEDER) and Catalan (AGAUR) grants 2017 SGR 1374 and SGR 1617. The third author is partially supported Convenio Marco UBB1755/2016-2020 No 84, FAPEMIG APQ-03149-18 and CNPq 433285/2018-4. The fourth author is partially supported by Math Amsud-Conicyt 17-Math-07 and Fondecyt 1180288.Peer ReviewedPostprint (author's final draft

Searching new proposals for medical teaching (social sciences contributions)

Pesquisa recente da CINAEM (Comissão Interinstitucional de Avaliação do Ensino Médico) aponta falhas na formação dos médicos brasileiros: deficiente formação ética e humanística; especialização precoce; preparo inadequado para o trabalho com a comunidade e para o atendimento às demandas da população. A formação de profissionais que atendam às exigências de um mercado extremamente competitivo e, ao mesmo tempo, engajados na realidade onde deverão atuar, é tarefa que se impõe a todos aqueles que pretendem colaborar na formação das novas gerações, nesta época marcada por profundas mudanças sociais.Recent research come out by CINAEM (Interinstitucional Comission to Evaluate Medical Students) brought out faults in the teaching and training of Brazilian medical students: deficient ethic and humanistic background; early  specialization not well prepared to deal with local communities considering actual community demand population. The training of professionals in an extremely competitive market, and at the same time conscious of the present social reality should be a matter of concern to be which addressed by those involved in the preparation of new generations in our age, marked by great special changes

Empowering machine learning models with contextual knowledge for enhancing the detection of eating disorders in social media posts

Social networks have become information dissemination channels, where announcements are posted frequently; they also serve as frameworks for debates in various areas (e.g., scientific, political, and social). In particular, in the health area, social networks represent a channel to communicate and disseminate novel treatments' success; they also allow ordinary people to express their concerns about a disease or disorder. The Artificial Intelligence (AI) community has developed analytical methods to uncover and predict patterns from posts that enable it to explain news about a particular topic, e.g., mental disorders expressed as eating disorders or depression. Albeit potentially rich while expressing an idea or concern, posts are presented as short texts, preventing, thus, AI models from accurately encoding these posts' contextual knowledge. We propose a hybrid approach where knowledge encoded in community-maintained knowledge graphs (e.g., Wikidata) is combined with deep learning to categorize social media posts using existing classification models. The proposed approach resorts to state-of-the-art named entity recognizers and linkers (e.g., Falcon 2.0) to extract entities in short posts and link them to concepts in knowledge graphs. Then, knowledge graph embeddings (KGEs) are utilized to compute latent representations of the extracted entities, which result in vector representations of the posts that encode these entities' contextual knowledge extracted from the knowledge graphs. These KGEs are combined with contextualized word embeddings (e.g., BERT) to generate a context-based representation of the posts that empower prediction models. We apply our proposed approach in the health domain to detect whether a publication is related to an eating disorder (e.g., anorexia or bulimia) and uncover concepts within the discourse that could help healthcare providers diagnose this type of mental disorder. We evaluate our approach on a dataset of 2,000 tweets about eating disorders. Our experimental results suggest that combining contextual knowledge encoded in word embeddings with the one built from knowledge graphs increases the reliability of the predictive models. The ambition is that the proposed method can support health domain experts in discovering patterns that may forecast a mental disorder, enhancing early detection and more precise diagnosis towards personalized medicine

O CUIDADO DA SAÚDE DA MULHER NA GESTAÇÃO, PARTO E PUEPÉRIO

Women's health during pregnancy is a topic of attention today, as it relates to health measures to prevent illnesses during this period and ensure a healthy birth. The activities of the Ministry of Health focus on promoting and supporting pregnant women to prevent diseases that affect the health of women and their babies. Health departments should focus on introducing health education strategies, prenatal care, providing information and protecting pregnant women. The objective of this study is to show the main support programs for pregnant women and the concept of maternal care through activities in the sector to guarantee women's health. We chose a method that uses a literature review approach, searching the Nursing Database (BDENF), Online Scientific Electronic Library (SCIELO), PubMed and Literature on Health Sciences from Latin America and the Caribbean (LILACS). We selected six studies to represent our understanding of antenatal care published between 2007 and 2024. The results showed that maternal health, including antenatal care, identified and treated illnesses during pregnancy, which met national health system guidelines. health. It is clear that to ensure a safe birth, the mother's recovery and the newborn's recovery, healthcare teams must be fully prepared to care for and support the pregnant woman.A saúde da mulher durante a gravidez é tema de atenção atualmente, pois se relaciona às medidas sanitárias para prevenir doenças nesse período e garantir um parto saudável. As atividades do Ministério da Saúde centram-se na promoção e apoio às mulheres grávidas para prevenir doenças que afetam a saúde das mulheres e dos seus bebés. Os departamentos de saúde devem concentrar-se na introdução de estratégias de educação para a saúde, cuidados pré-natais, fornecimento de informação e proteção das mulheres grávidas. O objetivo deste estudo é mostrar os principais programas de apoio às gestantes e o conceito de cuidado materno por meio de atividades no setor para garantir a saúde da mulher. Escolhemos um método que utiliza uma abordagem de revisão de literatura, pesquisando Base de Dados de Enfermagem (BDENF), Biblioteca Eletrônica Científica Online (SCIELO), PubMed e Literatura em Ciências da Saúde da América Latina e do Caribe (LILACS). Selecionamos seis estudos para representar nossa compreensão sobre cuidados pré-natais publicados entre 2007 e 2024. Os resultados mostraram que a saúde materna, incluindo os cuidados pré-natais, identificou e tratou doenças durante a gravidez, o que atendeu às diretrizes do sistema nacional de saúde. Fica claro que para garantir um parto seguro, a recuperação da mãe e a recuperação do recém-nascido, as equipes de saúde devem estar totalmente preparadas para cuidar e apoiar a gestante

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

CCQM-K55.b (Aldrin) : Final report: october 2012. CCQM-K55.b key comparison on the characterization of organic substances for chemical purity

Under the auspices of the Organic Analysis Working Group (OAWG) of the Comité Consultatif pour la Quantité de Matière (CCQM) a key comparison, CCQM K55.b, was coordinated by the Bureau International des Poids et Mesures (BIPM) in 2010/2011. Nineteen national measurement institutes and the BIPM participated. Participants were required to assign the mass fraction of aldrin present as the main component in the comparison sample for CCQM-K55.b which consisted of technical grade aldrin obtained from the National Measurement Institute Australia that had been subject to serial recrystallization and drying prior to sub-division into the units supplied for the comparison. Aldrin was selected to be representative of the performance of a laboratory's measurement capability for the purity assignment of organic compounds of medium structural complexity [molar mass range 300 Da to 500 Da] and low polarity (pKOW < −2) for which related structure impurities can be quantified by capillary gas phase chromatography (GC). The key comparison reference value (KCRV) for the aldrin content of the material was 950.8 mg/g with a combined standard uncertainty of 0.85 mg/g. The KCRV was assigned by combination of KCRVs assigned by consensus from participant results for each orthogonal impurity class. The relative expanded uncertainties reported by laboratories having results consistent with the KCRV ranged from 0.3% to 0.6% using a mass balance approach and 0.5% to 1% using a qNMR method. The major analytical challenge posed by the material proved to be the detection and quantification of a significant amount of oligomeric organic material within the sample and most participants relying on a mass balance approach displayed a positive bias relative to the KCRV (overestimation of aldrin content) in excess of 10 mg/g due to not having adequate procedures in place to detect and quantify the non-volatile content—specifically the non-volatile organics content—of the comparison sample. There was in general excellent agreement between participants in the identification and the quantification of the total and individual related structure impurities, water content and the residual solvent content of the sample. The comparison demonstrated the utility of 1H NMR as an independent method for quantitative analysis of high purity compounds. In discussion of the participant results it was noted that while several had access to qNMR estimates for the aldrin content that were inconsistent with their mass balance determination they decided to accept the mass balance result and assumed a hidden bias in their NMR data. By contrast, laboratories that placed greater confidence in their qNMR result were able to resolve the discrepancy through additional studies that provided evidence of the presence of non-volatile organic impurity at the requisite level to bring their mass balance and qNMR estimates into agreement.Fil: Westwood, Steven. Bureau International des Poids et Mesures (BIPM); FranciaFil: Josephs, Ralf. Bureau International des Poids et Mesures (BIPM); FranciaFil: Choteau, Tiphaine. Bureau International des Poids et Mesures (BIPM); FranciaFil: Daireaux, Adeline. Bureau International des Poids et Mesures (BIPM); FranciaFil: Mesquida, Charline. Bureau International des Poids et Mesures (BIPM); FranciaFil: Wielgosz, Robert. Bureau International des Poids et Mesures (BIPM); FranciaFil: Rosso, Adriana. Instituto Nacional de Tecnología Industrial (INTI); ArgentinaFil: Ruiz de Arechavaleta, Mariana. Instituto Nacional de Tecnología Industrial (INTI); ArgentinaFil: Davies, Stephen. National Measurement Institute (NMIA); AustraliaFil: Wang, Hongjie. National Measurement Institute (NMIA); AustraliaFil: Pires do Rego, Eliane Cristina. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Marques Rodrigues, Janaína. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: de Freitas Guimarães, Evelyn. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Barreto Sousa, Marcus Vinicius. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Monteiro, Tânia Maria. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Alves das Neves Valente, Laura. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Marques Violante, Fernando Gustavo. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Rubim, Renato. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Almeida, Ribeiro. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Baptista Quaresma, Maria Cristina. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Nogueira, Raquel. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Windust, Anthony. Institute for National Measurement Standards. National Research Council Canada (NRC-INMS); CanadáFil: Dai, Xinhua. National Institute of Metrology (NIM); ChinaFil: Li, Xiaomin. National Institute of Metrology (NIM); ChinaFil: Zhang, Wei. National Institute of Metrology (NIM); ChinaFil: Li, Ming. National Institute of Metrology (NIM); ChinaFil: Shao, Mingwu. National Institute of Metrology (NIM); ChinaFil: Wei, Chao. National Institute of Metrology (NIM); ChinaFil: Wong, Siu-kay. Government Laboratory of Hong Kong SAR (GLHK); ChinaFil: Cabillic, Julie. Laboratoire National de Métrologie et d’Essais (LNE); FranciaFil: Gantois, Fanny. Laboratoire National de Métrologie et d’Essais (LNE); FranciaFil: Philipp, Rosemarie. Bundesanstalt für Materialforschung (BAM); AlemaniaFil: Pfeifer, Dietmar. Bundesanstalt für Materialforschung (BAM); AlemaniaFil: Hein, Sebastian. Bundesanstalt für Materialforschung (BAM); AlemaniaFil: Klyk-Seitz, Urszula-Anna. Bundesanstalt für Materialforschung (BAM); AlemaniaFil: Ishikawa, Keiichiro. National Metrology Institute of Japan (NMIJ); JapónFil: Castro, Esther. Centro Nacional de Metrología (CENAM); MéxicoFil: Gonzalez, Norma. Centro Nacional de Metrología (CENAM); MéxicoFil: Krylov, Anatoly. D. I. Mendeleev Institute for Metrology (VNIIM); RusiaFil: Lin, Teo Tang. Health Sciences Authority (HSA); SingapurFil: Kooi, Lee Tong. Health Sciences Authority (HSA); SingapurFil: Fernandes-Whaley, M. National Metrology Institute of South Africa (NMISA); SudáfricaFil: Prévoo, D. National Metrology Institute of South Africa (NMISA); SudáfricaFil: Archer, M. National Metrology Institute of South Africa (NMISA); SudáfricaFil: Visser, R. National Metrology Institute of South Africa (NMISA); SudáfricaFil: Nlhapo, N. National Metrology Institute of South Africa (NMISA); SudáfricaFil: de Vos, B. National Metrology Institute of South Africa (NMISA); SudáfricaFil: Ahn, Seonghee. Korea Research Institute of Standards and Science (KRISS); Corea del SurFil: Pookrod, Preeyaporn. National Institute of Metrology of Thailand (NIMT); TailandiaFil: Wiangnon, Kanjana. National Institute of Metrology of Thailand (NIMT); TailandiaFil: Sudsiri, Nittaya. National Institute of Metrology of Thailand (NIMT); TailandiaFil: Muaksang, Kittiya. National Institute of Metrology of Thailand (NIMT); TailandiaFil: Cherdchu, Chainarong. National Institute of Metrology of Thailand (NIMT); TailandiaFil: Gören, Ahmet Ceyhan. National Metrology Institute (TUBITAK UME); TurquíaFil: Bilsel, Mine. National Metrology Institute (TUBITAK UME); TurquíaFil: LeGoff, Thierry. LGC Limited; Reino UnidoFil: Bearden, Dan. National Institute of Standards and Technology (NIST); Estados UnidosFil: Bedner, Mary. National Institute of Standards and Technology (NIST); Estados UnidosFil: Duewer, David. National Institute of Standards and Technology (NIST); Estados UnidosFil: Hancock, Diane. National Institute of Standards and Technology (NIST); Estados UnidosFil: Lang, Brian. National Institute of Standards and Technology (NIST); Estados UnidosFil: Lippa, Katrice. National Institute of Standards and Technology (NIST); Estados UnidosFil: Schantz, Michele. National Institute of Standards and Technology (NIST); Estados UnidosFil: Sieber, John. National Institute of Standards and Technology (NIST); Estados Unido

Semi-industrial development of nutritious and healthy seafood dishes from sustainable species

This study aimed to devise innovative, tailor-made, appealing, tasty and semi-industrialized dishes, using sustainable and under-utilized seafood species (bib, common dab, common carp, blue mussel and blue whiting), that can meet the specific nutritional and functional needs of children (8-10-years), pregnant women (20-40-years) and seniors (≥60-years). Hence, contests were organised among cooking schools from 6 European countries and the best recipes/dishes were reformulated, semi-industrially produced and chemically and microbiologically evaluated. The dishes intended for: (i) children and pregnant women had EPA + DHA and I levels that reached the target quantities, supporting the claim as "high in I"; and (ii) seniors were "high in protein" (24.8%-Soup_S and 34.0%-Balls_S of the energy was provided by proteins), "high in vitamin B12", and had Na contents (≤0.4%) below the defined limit. All dishes reached the vitamin D target value. Sausages_C, Roulade_P, Fillet_P and Balls_S had a well-balanced protein/fat ratio. Roulade_P presented the highest n-3 PUFA/n-6 PUFA ratio (3.3), while Sausages_C the lowest SFA/UNS ratio (0.2). Dishes were considered safe based on different parameters (e.g. Hg-T, PBDEs, Escherichia coli). All represent dietary sources contributing to meet the reference intakes of target nutrients (33->100%), providing valuable options to overcome nutritional and functional imbalances of the three groups.This project has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement no. 773400 (SEAFOODTOMORROW). This work was also supported by the Spanish Ministry of Science and Innovation (Project CEX 2018-000794-S), the Generalitat de Catalunya (Consolidated Research Group Water and Soil Quality Unit 2017 SGR 1404) and Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through national funds (UID/QUI/50006/2019, UIDB/50006/2020, UIDP/50006/2020, UIDB/04423/2020 and UIDP/04423/2020). The authors also thank FCT and the European Union's H2020 Research and Innovation Programme for funding through the project Systemic - An integrated approach to the challenge of sustainable food systems: adaptive and mitigatory strategies to address climate change and malnutrition. Sara Cunha also acknowledges FCT for the IF/01616/2015 contract. Biotage is acknowledged for providing SPE cartridges and Bekolut for the QuEChERS kits. This output reflects the views only of the author(s), and the European Union cannot be held responsible for any use that may be made of the information contained therein.Peer reviewe

Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that present variable outcomes. To date, no effective therapies or reliable prognostic markers are available for patients who develop metastatic PPGL (mPPGL). Our aim was to discover robust prognostic markers validated through models, and define specific therapeutic options according to tumor genomic features. : We analyzed three PPGL miRNome datasets (n=443), validated candidate markers and assessed them in serum samples (n=36) to find a metastatic miRNA signature. An integrative study of miRNome, transcriptome and proteome was performed to find miRNA targets, which were further characterized . : A signature of six miRNAs (miR-21-3p, miR-183-5p, miR-182-5p, miR-96-5p, miR-551b-3p, and miR-202-5p) was associated with metastatic risk and time to progression. A higher expression of five of these miRNAs was also detected in PPGL patients' liquid biopsies compared with controls. The combined expression of miR-21-3p/miR-183-5p showed the best power to predict metastasis (AUC=0.804, =4.67·10), and was found associated with pro-metastatic features, such as neuroendocrine-mesenchymal transition phenotype, and increased cell migration rate. A pan-cancer multi-omic integrative study correlated miR-21-3p levels with TSC2 expression, mTOR pathway activation, and a predictive signature for mTOR inhibitor-sensitivity in PPGLs and other cancers. Likewise, we demonstrated a repression and an enhanced rapamycin sensitivity upon miR-21-3p expression. : Our findings support the assessment of miR-21-3p/miR-183-5p, in tumors and liquid biopsies, as biomarkers for risk stratification to improve the PPGL patients' management. We propose miR-21-3p to select mPPGL patients who may benefit from mTOR inhibitors