Diagnosis Of Infant Synostotic And Nonsynostotic Cranial Deformities: A Review For Pediatricians

34449550

Platform for space management in a higher education school

Nas instituições de ensino superior há uma cada vez maior variedade de atividades de ensino e investigação a desenvolver que necessitam de espaços apropriados e adaptados às necessidades. Sendo que algumas ações têm prioridade e restrições mais exigentes que outras há que fazer uma gestão eficiente dos recursos nomeadamente dos espaços a reservar. Nesse sentido, é apresentado neste artigo uma plataforma de gestão de espaços aplicada a uma escola do ensino superior, mas que pode ser facilmente adaptada a outras instalações.In higher education institutions there is an increasing variety of teaching and research activities to be developed that need appropriate spaces and adapted to needs. Since some actions have more demanding priorities and restrictions than others, it is necessary to make an efficient management of resources, namely the spaces to be reserved. In this sense, this article presents a space management platform applied to a higher education school but which can be easily adapted to other installations.Este trabalho foi apoiado pela FCT - Fundação para a Ciência e Tecnologia no âmbito do Projeto: UIDB /05757/2020. Agradecimentos ao Instituto Politécnico de Bragança por fornecer os recursos necessários para realização deste trabalho.info:eu-repo/semantics/publishedVersio

Le Fort II osteotomy for medium-face fracture sequel correction

Introduction: Fractures should be treated by a multi-professional team to minimize sequels. The surgery aims to establish a good maxillary, mandibular relationship to improve mastication and phonetics and may benefit esthetics. Objective: to report the surgical procedure with Le Fort II osteotomy for correction of class III dentofacial deformity and the nasomaxillary deficiency caused by trauma. Case report: Patient victim of aggression for 10 years suffered a Le Fort II fracture. The fracture was not treated and the patient developed a severe anteroposterior defect of the nasomaxillary complex andClass III occlusion. The surgery for correcting deformities was performed with the bicoronal, lower eyelid and intraoral accesses. Le Fort II pyramidal osteotomy was performed with a piezoelectric motor to advance 7 mm the nasomaxillary complex. Conclusion: Le Fort II osteotomy is considered satisfactory for advancing the nasomaxillary complex, improving the patient´s psychosocial function and development.Introduction: Fractures should be treated by a multi-professional team to minimize sequels. The surgery aims to establish a good maxillary, mandibular relationship to improve mastication and phonetics and may benefit esthetics. Objective: to report the surgical procedure with Le Fort II osteotomy for correction of class III dentofacial deformity and the nasomaxillary deficiency caused by trauma. Case report: Patient victim of aggression for 10 years suffered a Le Fort II fracture. The fracture was not treated and the patient developed a severe anteroposterior defect of the nasomaxillary complex andClass III occlusion. The surgery for correcting deformities was performed with the bicoronal, lower eyelid and intraoral accesses. Le Fort II pyramidal osteotomy was performed with a piezoelectric motor to advance 7 mm the nasomaxillary complex. Conclusion: Le Fort II osteotomy is considered satisfactory for advancing the nasomaxillary complex, improving the patient´s psychosocial function and development

Astrocytic expression of GFAP and serum levels of IL-1β and TNF-α in rats treated with different pain relievers

Pro-inflammatory cytokines and glial cells, especially microglial cells, have been implicated in persistent pain sensitization. Less is known about the role of astrocytes in pain regulation. This study aimed to observe the expression of the astrocytic biomarker glial fibrillary acidic protein (GFAP) and the serum levels of interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) after short-term administration of central pain relievers in rats not submitted to noxious stimuli. Male Wistar rats were divided into five groups, receiving for nine days- (1) amitriptyline (Amt-10 mg/kg/day, by gavage); (2) gabapentin (Gb-60 mg/kg/day, by gavage; (3) methadone (Me-4.5 mg/kg/day, intraperitoneal route [IP]); (4) morphine (Mo-10 mg/kg/day, IP); or (5) 0.9% saline solution, IP. Brain samples were collected for immunohistochemical study of GFAP expression in the mesencephalon and nucleus accumbens (NAc). The area of GFAP-positive cells was calculated using MetaMorph software and serum levels of IL-1β and TNF-α were measured by enzyme-linked immunosorbent assay. Serum TNF-α levels were decreased in the groups treated with Mo, Me and Gb, but not in the Amt-treated group. IL-1β decreased only in rats treated with Me. The astrocytic expression of GFAP was decreased in the brainstem with all drugs, while it was increased in the NAc with Amt, Me and Mo

Effects of Exercise Training on Circulating and Skeletal Muscle Renin-Angiotensin System in Chronic Heart Failure Rats

Background: Accumulated evidence shows that the ACE-AngII-AT1 axis of the renin-angiotensin system (RAS) is markedly activated in chronic heart failure (CHF). Recent studies provide information that Angiotensin (Ang)-(1-7), a metabolite of AngII, counteracts the effects of AngII. However, this balance between AngII and Ang-(1-7) is still little understood in CHF. We investigated the effects of exercise training on circulating and skeletal muscle RAS in the ischemic model of CHF.Methods/Main Results: Male Wistar rats underwent left coronary artery ligation or a Sham operation. They were divided into four groups: 1) Sedentary Sham (Sham-S), 2) exercise-trained Sham (Sham-Ex), sedentary CHF (CHF-S), and exercise-trained CHF (CHF-Ex). Angiotensin concentrations and ACE and ACE2 activity in the circulation and skeletal muscle (soleus and plantaris) were quantified. Skeletal muscle ACE and ACE2 protein expression, and AT1, AT2, and Mas receptor gene expression were also evaluated. CHF reduced ACE2 serum activity. Exercise training restored ACE2 and reduced ACE activity in CHF. Exercise training reduced plasma AngII concentration in both Sham and CHF rats and increased the Ang-(1-7)/AngII ratio in CHF rats. CHF and exercise training did not change skeletal muscle ACE and ACE2 activity and protein expression. CHF increased AngII levels in both soleus and plantaris muscle, and exercise training normalized them. Exercise training increased Ang-(1-7) in the plantaris muscle of CHF rats. the AT1 receptor was only increased in the soleus muscle of CHF rats, and exercise training normalized it. Exercise training increased the expression of the Mas receptor in the soleus muscle of both exercise-trained groups, and normalized it in plantaris muscle.Conclusions: Exercise training causes a shift in RAS towards the Ang-(1-7)-Mas axis in skeletal muscle, which can be influenced by skeletal muscle metabolic characteristics. the changes in RAS circulation do not necessarily reflect the changes occurring in the RAS of skeletal muscle.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundacao ZerbiniCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ São Paulo, Sch Med, Heart Inst InCor HCFMUSP, São Paulo, BrazilUniv São Paulo, Sch Phys Educ & Sport, São Paulo, BrazilUniv São Paulo, Inst Biomed Sci, Dept Physiol & Biophys, São Paulo, BrazilUniversidade Federal de São Paulo, Kidney & Hypertens Hosp, Div Nephrol, São Paulo, BrazilUniversidade Federal de São Paulo, Kidney & Hypertens Hosp, Div Nephrol, São Paulo, BrazilFAPESP: FAPESP-2010/50048-1Web of Scienc

Fatores imunogenéticos associados ao diabetes mellitus do tipo 1

Type 1 diabetes mellitus has been considered an organ-specific autoimmune disease derived from the selective destruction of pancreatic beta cells. It presents a complex pathogenesis, involving the participation of several factors, including the immunogenetic susceptibility with strong association to histocompatibility genes (HLA), environmental events and autoimmune response with the presence of autoantibodies and/or autoreactive lymphocytes, culminating in metabolic abnormalities. In this study, the literature review describes mechanisms through which some factors cause susceptibility to its appearance and, additionally, prediction innovations regarding this disorder, which will certainly contribute to nursing care for patients with type 1 diabetes.La Diabetes Mellitus tipo 1 ha sido considerada una enfermedad autoinmune órgano-específica debido a la destrucción selectiva de las células beta pancreáticas. Presenta una patogenia compleja, involucrando la participación de varios factores, entre esos la susceptibilidad inmunogenética con fuerte asociación a los genes de histocompatibilidad (HLA), eventos ambientales y respuesta autoinmune con presencia de auto-anticuerpos y/o linfocitos auto-reactivos, culminando en anormalidades metabólicas. En este estudio, la revisión de la literatura describe los mecanismos por los cuales determinados factores resultan en susceptibilidad para su desarrollo y, adicionalmente, las innovaciones en la predicción de ese desorden que, por cierto, van a contribuir para la atención de enfermería a los pacientes portadores de la diabetes tipo 1.O diabetes mellitus do tipo 1 tem sido considerado uma doença auto-imune órgão-específica, decorrente da destruição seletiva das células betapancreáticas. Apresenta patogenia complexa, envolvendo a participação de vários fatores, dentre esses a susceptibilidade imunogenética com forte associação aos genes de histocompatibilidade (HLA), eventos ambientais e resposta auto-imune com presença de auto-anticorpos e/ou linfócitos auto-reativos, culminando em anormalidades metabólicas. Neste estudo, a revisão da literatura descreve os mecanismos pelos quais determinados fatores conferem susceptibilidade para o seu desencadeamento e, adicionalmente, as inovações na predição dessa desordem que, certamente, contribuirão para a assistência de enfermagem aos pacientes portadores do diabetes tipo 1

Avaliação de indicadores de manejo ambiental em sistemas de produção agrícola de altinópolis-sp

Para analisar e comparar os sistemas de produção agrícolas no município de Altinópolis-SP foram identificados indicadores ambientais, como proposto pelo método MESMIS. Estes indicadores foram mensurados através de pesquisa de campo, com participação dos agricultores locais. Foi possível observar que, as propriedades familiares ( 4 módulos fiscais), apresentaram como destaque baixa mobilização do solo, correção do solo freqüente e presença de APP averbada.To analyze and compare the agricultural production systems in the municipality of Altinópolis-SP were identified environmental indicators as proposed by MESMIS method. These indicators were measured through field research, with the participation of local farmers. It was observed that family farms ( fiscal modules) presented as a highlight: low tillage, frequent soil correction and regularized presence of APP.Eje A4: Ambiente, Naturaleza y AgroecologíaFacultad de Ciencias Agrarias y Forestale

Avaliação de indicadores de manejo ambiental em sistemas de produção agrícola de altinópolis-sp

Para analisar e comparar os sistemas de produção agrícolas no município de Altinópolis-SP foram identificados indicadores ambientais, como proposto pelo método MESMIS. Estes indicadores foram mensurados através de pesquisa de campo, com participação dos agricultores locais. Foi possível observar que, as propriedades familiares ( 4 módulos fiscais), apresentaram como destaque baixa mobilização do solo, correção do solo freqüente e presença de APP averbada.To analyze and compare the agricultural production systems in the municipality of Altinópolis-SP were identified environmental indicators as proposed by MESMIS method. These indicators were measured through field research, with the participation of local farmers. It was observed that family farms ( fiscal modules) presented as a highlight: low tillage, frequent soil correction and regularized presence of APP.Eje A4: Ambiente, Naturaleza y AgroecologíaFacultad de Ciencias Agrarias y Forestale

Avaliação de indicadores de manejo ambiental em sistemas de produção agrícola de altinópolis-sp

Para analisar e comparar os sistemas de produção agrícolas no município de Altinópolis-SP foram identificados indicadores ambientais, como proposto pelo método MESMIS. Estes indicadores foram mensurados através de pesquisa de campo, com participação dos agricultores locais. Foi possível observar que, as propriedades familiares ( 4 módulos fiscais), apresentaram como destaque baixa mobilização do solo, correção do solo freqüente e presença de APP averbada.To analyze and compare the agricultural production systems in the municipality of Altinópolis-SP were identified environmental indicators as proposed by MESMIS method. These indicators were measured through field research, with the participation of local farmers. It was observed that family farms ( fiscal modules) presented as a highlight: low tillage, frequent soil correction and regularized presence of APP.Eje A4: Ambiente, Naturaleza y AgroecologíaFacultad de Ciencias Agrarias y Forestale