4,913 research outputs found
Neuronal Premotor Networks Involved in Eyelid Responses: Retrograde Transneuronal Tracing with Rabies Virus from the Orbicularis Oculi Muscle in the Rat
Retrograde transneuronal tracing with rabies virus from the right orbicularis oculi muscle was used to identify neural networks underlying spontaneous, reflex, and learned blinks. The kinetics of viral transfer was studied at sequential 12 hr intervals between 3 and 5 d after inoculation. Rabies virus immunolabeling was combined with the immunohistochemical detection of choline acetyltransferase expression in brainstem motoneurons or Fluoro-Ruby injections in the rubrospinal tract. Virus uptake involved exclusively orbicularis oculi motoneurons in the dorsolateral division of the facial nucleus. At 3-3.5 d, transneuronal transfer involved premotor interneurons of trigeminal, auditory, and vestibular reflex pathways (in medullary and pontine reticular formation, trigeminal nuclei, periolivary and ventral cochlear nuclei, and medial vestibular nuclei), motor pathways (dorsolateral quadrant of contralateral red nucleus and pararubral area), deep cerebellar nuclei (lateral portion of interpositus nucleus and dorsolateral hump ipsilaterally), limbic relays (parabrachial and Kölliker-Fuse nuclei), and oculomotor structures involved in eye-eyelid coordination (oculomotor nucleus, supraoculomotor area, and interstitial nucleus of Cajal). At 4 d, higher order neurons were revealed in trigeminal, auditory, vestibular, and deep cerebellar nuclei (medial, interpositus, and lateral), oculomotor and visual-related structures (Darkschewitsch, nucleus of the posterior commissure, deep layers of superior colliculus, and pretectal area), lateral hypothalamus, and cerebral cortex (particularly in parietal areas). At 4.5 and 5 d the labeling of higher order neurons occurred in hypothalamus, cerebral cortex, and blink-related areas of cerebellar cortex. These results provide a comprehensive picture of the premotor networks mediating reflex, voluntary, and limbic-related eyelid responses and highlight potential sites of motor learning in eyelid classical conditioning
Handlebar injury in children: Are we ignoring the signs?
AbstractThe diagnosis of blunt intestinal injury in children is difficult and often delayed. We describe two cases of delayed diagnosis of intestinal injury following handlebar injury with abdominal wall tattooing. We review the literature to try and determine the usefulness of handlebar tattooing characteristics as a clinical sign for underlying small bowel injury in order to reduce delayed treatment. We propose a management algorithm for patients with handlebar tattooing
Alarm-Based Prescriptive Process Monitoring
Predictive process monitoring is concerned with the analysis of events
produced during the execution of a process in order to predict the future state
of ongoing cases thereof. Existing techniques in this field are able to
predict, at each step of a case, the likelihood that the case will end up in an
undesired outcome. These techniques, however, do not take into account what
process workers may do with the generated predictions in order to decrease the
likelihood of undesired outcomes. This paper proposes a framework for
prescriptive process monitoring, which extends predictive process monitoring
approaches with the concepts of alarms, interventions, compensations, and
mitigation effects. The framework incorporates a parameterized cost model to
assess the cost-benefit tradeoffs of applying prescriptive process monitoring
in a given setting. The paper also outlines an approach to optimize the
generation of alarms given a dataset and a set of cost model parameters. The
proposed approach is empirically evaluated using a range of real-life event
logs
The cosmic evolution of the spatially-resolved star formation rate and stellar mass of the CALIFA survey
We investigate the cosmic evolution of the absolute and specific star
formation rate (SFR, sSFR) of galaxies as derived from a spatially-resolved
study of the stellar populations in a set of 366 nearby galaxies from the
CALIFA survey. The analysis combines GALEX and SDSS images with the 4000 break,
H_beta, and [MgFe] indices measured from the datacubes, to constrain parametric
models for the SFH, which are then used to study the cosmic evolution of the
star formation rate density (SFRD), the sSFR, the main sequence of star
formation (MSSF), and the stellar mass density (SMD). A delayed-tau model,
provides the best results, in good agreement with those obtained from
cosmological surveys. Our main results from this model are: a) The time since
the onset of the star formation is larger in the inner regions than in the
outer ones, while tau is similar or smaller in the inner than in the outer
regions. b) The sSFR declines rapidly as the Universe evolves, and faster for
early than for late type galaxies, and for the inner than for the outer regions
of galaxies. c) SFRD and SMD agree well with results from cosmological surveys.
At z< 0.5, most star formation takes place in the outer regions of late spiral
galaxies, while at z>2 the inner regions of the progenitors of the current E
and S0 are the major contributors to SFRD. d) The inner regions of galaxies are
the major contributor to SMD at z> 0.5, growing their mass faster than the
outer regions, with a lookback time at 50% SMD of 9 and 6 Gyr for the inner and
outer regions. e) The MSSF follows a power-law at high redshift, with the slope
evolving with time, but always being sub-linear. f) In agreement with galaxy
surveys at different redshifts, the average SFH of CALIFA galaxies indicates
that galaxies grow their mass mainly in a mode that is well represented by a
delayed-tau model, with the peak at z~2 and an e-folding time of 3.9 Gyr.Comment: 23 pages, 16 figures, 6 tables, accepted for publication in Astronomy
& Astrophysics. *Abridged abstract
The spatially resolved star formation history of CALIFA galaxies: Cosmic time scales
This paper presents the mass assembly time scales of nearby galaxies observed
by CALIFA at the 3.5m telescope in Calar Alto. We apply the fossil record
method of the stellar populations to the complete sample of the 3rd CALIFA data
release, with a total of 661 galaxies, covering stellar masses from 10
to 10 M and a wide range of Hubble types. We apply spectral
synthesis techniques to the datacubes and process the results to produce the
mass growth time scales and mass weighted ages, from which we obtain temporal
and spatially resolved information in seven bins of galaxy morphology and six
bins of stellar mass (M) and stellar mass surface density
(). We use three different tracers of the spatially resolved
star formation history (mass assembly curves, ratio of half mass to half light
radii, and mass-weighted age gradients) to test if galaxies grow inside-out,
and its dependence with galaxy stellar mass, , and morphology.
Our main results are as follows: (a) The innermost regions of galaxies assemble
their mass at an earlier time than regions located in the outer parts; this
happens at any given M, , or Hubble type, including
the lowest mass systems. (b) Galaxies present a significant diversity in their
characteristic formation epochs for lower-mass systems. This diversity shows a
strong dependence of the mass assembly time scales on and
Hubble type in the lower-mass range (10 to 10), but a very
mild dependence in higher-mass bins. (c) All galaxies show negative
log age gradients in the inner 1 HLR. The profile
flattens with increasing values of . There is no significant
dependence on M within a particular bin, except for
the lowest bin, where the gradients becomes steeper.Comment: 15 pages, 13 figures, 3 tables, accepted for publication in Astronomy
& Astrophysics. *Abridged abstract
Paternity assessment in free ranging wild boar (Sus scrofa) - Are littermates full-sibs?
Multiple paternity within litters occurs in various groups of mammals exhibiting different mating systems. Using seven genetic markers (i.e., microsatellites) we investigated the paternity of littermates in free ranging wild boar (Sus scrofa) in a Mediterranean habitat. Using the software CERVUS 2.0 we estimated the probability of detecting multiple paternity across all loci (D), the probability of paternity (W) and a statistic ∆ that allows the assignment of paternity to the most likely male with strict and relaxed levels of confidence. Multiple paternity was inferred for one of the nine analysed litters at the 80% confidence level. This suggests that a single male may control the access to receptive adult females and it shows that multiple paternity is not very common in the studied free ranging wild boar population. Despite the possible occurrence of sperm competition and/or female cryptic choice, mate guarding seems to play a significant role in sexual selection. To better understand the wild boar’s mating strategies further studies analysing the reproductive success of both sexes and under different environmental conditions should be conducted
Chelating properties of tripeptide-9 citrulline
Tripeptide-9 Citrulline (INCI name) is a peptide with skin care properties, used for cosmetic applications. In order to elucidate its mechanism of action in the chemical pathways that involve metal ions, its ability to complex such ions was investigated using spectrophotometrical, electrochemical and electrophoretical techniques. The obtained results using Cu(II) as metal ion were consistent with the formation of a complex between Tripeptide-9 Citrulline andCu(II). Cyclic voltammetry revealed a significant changein the electrochemical potentials. In-vitro electrophoretic studies served as a proof of concept that Tripeptide-9 Citrullinemay protect DNA from radical degradation induced by the Fenton reaction
- …