The shape of primordial non-Gaussianity and the CMB bispectrum

We present a set of formalisms for comparing, evolving and constraining primordial non-Gaussian models through the CMB bispectrum. We describe improved methods for efficient computation of the full CMB bispectrum for any general (non-separable) primordial bispectrum, incorporating a flat sky approximation and a new cubic interpolation. We review all the primordial non-Gaussian models in the present literature and calculate the CMB bispectrum up to l <2000 for each different model. This allows us to determine the observational independence of these models by calculating the cross-correlation of their CMB bispectra. We are able to identify several distinct classes of primordial shapes - including equilateral, local, warm, flat and feature (non-scale invariant) - which should be distinguishable given a significant detection of CMB non-Gaussianity. We demonstrate that a simple shape correlator provides a fast and reliable method for determining whether or not CMB shapes are well correlated. We use an eigenmode decomposition of the primordial shape to characterise and understand model independence. Finally, we advocate a standardised normalisation method for $f_{NL}$ based on the shape autocorrelator, so that observational limits and errors can be consistently compared for different models.Comment: 32 pages, 20 figure

Primordial non-Gaussianity and the CMB bispectrum

We present a new formalism, together with efficient numerical methods, to directly calculate the CMB bispectrum today from a given primordial bispectrum using the full linear radiation transfer functions. Unlike previous analyses which have assumed simple separable ansatze for the bispectrum, this work applies to a primordial bispectrum of almost arbitrary functional form, for which there may have been both horizon-crossing and superhorizon contributions. We employ adaptive methods on a hierarchical triangular grid and we establish their accuracy by direct comparison with an exact analytic solution, valid on large angular scales. We demonstrate that we can calculate the full CMB bispectrum to greater than 1% precision out to multipoles l<1800 on reasonable computational timescales. We plot the bispectrum for both the superhorizon ('local') and horizon-crossing ('equilateral') asymptotic limits, illustrating its oscillatory nature which is analogous to the CMB power spectrum

Rapid Separable Analysis of Higher Order Correlators in Large Scale Structure

We present an efficient separable approach to the estimation and reconstruction of the bispectrum and the trispectrum from observational (or simulated) large scale structure data. This is developed from general CMB (poly-)spectra methods which exploit the fact that the bispectrum and trispectrum in the literature can be represented by a separable mode expansion which converges rapidly (with $n_\textrm{max}={\cal{O}}(30)$ terms). With an effective grid resolution $l_\textrm{max}$ (number of particles/grid points $N=l_\textrm{max}^3$), we present a bispectrum estimator which requires only ${\cal O}(n_\textrm{max} \times l_\textrm{max}^3)$ operations, along with a corresponding method for direct bispectrum reconstruction. This method is extended to the trispectrum revealing an estimator which requires only ${\cal O}(n_\textrm{max}^{4/3} \times l_\textrm{max}^3)$ operations. The complexity in calculating the trispectrum in this method is now involved in the original decomposition and orthogonalisation process which need only be performed once for each model. However, for non-diagonal trispectra these processes present little extra difficulty and may be performed in ${\cal O}(l_\textrm{max}^4)$ operations. A discussion of how the methodology may be applied to the quadspectrum is also given. An efficient algorithm for the generation of arbitrary nonGaussian initial conditions for use in N-body codes using this separable approach is described. This prescription allows for the production of nonGaussian initial conditions for arbitrary bispectra and trispectra. A brief outline of the key issues involved in parameter estimation, particularly in the non-linear regime, is also given

Effect of folic acid supplementation in pregnancy on preeclampsia: The folic acid clinical trial study

Copyright © 2013 Shi Wu Wen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Preeclampsia (PE) is hypertension with proteinuria that develops during pregnancy and affects at least 5% of pregnancies. The Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia: the Folic Acid Clinical Trial (FACT) aims to recruit 3,656 high risk women to evaluate a new prevention strategy for PE: supplementation of folic acid throughout pregnancy. Pregnant women with increased risk of developing PE presenting to a trial participating center between 80/7 and 166/7 weeks of gestation are randomized in a 1: 1 ratio to folic acid 4.0 mg or placebo after written consent is obtained. Intent-to-treat population will be analyzed. The FACT study was funded by the Canadian Institutes of Health Research in 2009, and regulatory approval from Health Canada was obtained in 2010. A web-based randomization system and electronic data collection system provide the platform for participating centers to randomize their eligible participants and enter data in real time. To date we have twenty participating Canadian centers, of which eighteen are actively recruiting, and seven participating Australian centers, of which two are actively recruiting. Recruitment in Argentina, UK, Netherlands, Brazil, West Indies, and United States is expected to begin by the second or third quarter of 2013. This trial is registered with NCT01355159. © 2013 Shi Wu Wen et al.The Canadian Institutes of Healt

The Trans-Pacific Partnership Agreement: Looking Ahead to the Next Steps

Pressure has been building for the conclusion of the 12-country Trans-Pacific Partnership (TPP) negotiations. Getting the deal done is important, but the TPP is not just another free trade agreement (FTA). It represents the chance to set a trade agenda for the future across a wide range of topics for countries throughout the Asia-Pacific region. This means that the agreement should not be settled in haste. More importantly, it also means that key decisions need to be reached about broader issues related to the institutional structure of the TPP. These decisions must be made now, before the deal is closed, on issues such as how to create the TPP as a living agreement, the formation of a TPP Secretariat, and the clarification of entry conditions for future members such as the People’s Republic of China (PRC). These choices must be made deliberately and carefully even while officials are struggling with reaching closure on the most highly sensitive issues still remaining in the agreement. It will not be easy, but wise decisions are necessary now to ensure the long-term success of the TPP

Characterisation and properties of a small cell lung cancer cell line and xenograft WX322 with marked sensitivity to alpha-interferon.

Controversy exists as to whether interferons usefully influence the growth of epithelial carcinomas. A small cell lung carcinoma (SCLC) cell line, WX322, has been derived which is greater than 1000-fold more sensitive to alpha-interferon (IFN) when grown in agar than other reported SCLC cell lines. The WX322 line has been characterised to prove its epithelial origin and its chemosensitivity compared with that of the NCI-H69 small cell line. The WX322 cell line expresses neuroendocrine and epithelial markers and possesses a morphology consistent with SCLC origin. A concentration of 5 IU ml-1 of IFN produced 50% inhibition of colony formation in agar in the WX322 line, whereas a concentration of greater than 10(5) IU ml-1 was required to produce a comparable effect with the NCI-H69 cell line. In contrast, WX322, possessed similar sensitivity to NCI-H69 cells when exposed to a range of cytotoxic agents. Analysis of the cell cycle indicated that IFN increased the percentage of cells in the G0/G1 phase for the WX322 cell line but increased the percentage in S phase for the NCI-H69 line. Growth of the xenograft, from which the cell line was derived, was also inhibited by IFN at doses greater than 10(5) IU/mouse/day. The WX322 cell line whether grown in agar or as a xenograft shows an unusually high sensitivity to IFN and provides an interesting model for studying mechanisms of IFN cytotoxicity to epithelial cells

Optimal bispectrum constraints on single-field models of inflation

We use WMAP 9-year bispectrum data to constrain the free parameters of an 'effective field theory' describing fluctuations in single-field inflation. The Lagrangian of the theory contains a finite number of operators associated with unknown mass scales. Each operator produces a fixed bispectrum shape, which we decompose into partial waves in order to construct a likelihood function. Based on this likelihood we are able to constrain four linearly independent combinations of the mass scales. As an example of our framework we specialize our results to the case of 'Dirac-Born-Infeld' and 'ghost' inflation and obtain the posterior probability for each model, which in Bayesian schemes is a useful tool for model comparison. Our results suggest that DBI-like models with two or more free parameters are disfavoured by the data by comparison with single parameter models in the same class

Constraining Galileon inflation

In this short paper, we present constraints on the Galileon inflationary model from the CMB bispectrum. We employ a principal-component analysis of the independent degrees of freedom constrained by data and apply this to the WMAP 9-year data to constrain the free parameters of the model. A simple Bayesian comparison establishes that support for the Galileon model from bispectrum data is at best weak

Creating citizen-consumers? Public service reform and (un)willing selves

About the book: Postmodern theories heralded the "death of the subject", and thereby deeply contested our intuition that we are free and willing selves. In recent times, the (free) will has come under attack yet again. Findings from the neuro- and cognitive sciences claim the concept of will to be scientifically untenable, specifying that it is our brain rather than our 'self' which decides what we want to do. In spite of these challenges however, the willing self has come to take centre stage in our society: juridical and moral practices ascribing guilt, or the organization of everyday life attributing responsibilities, for instance, can hardly be understood without taking recourse to the willing subject. In this vein, the authors address topics such as the genealogy of the concept of willing selves, the discourse on agency in neuroscience and sociology, the political debate on volition within neoliberal and neoconservative regimes, approaches toward novel forms of relational responsibility as well as moral evaluations in conceptualizing autonomy