QZ Serpentis: A Dwarf Nova with a 2-Hour Orbital Period and an Anomalously Hot, Bright Secondary Star

We present spectroscopy and time-series photometry of the dwarf nova QZ Ser. The spectrum shows a rich absorption line spectrum of type K4 +- 2. K-type secondary stars are generally seen in dwarf novae with orbital periods P-orb around 6 h, but in QZ Ser the absorption radial velocities show an obvious modulation (semi-amplitude 207(5) km/s) at P-orb = 119.752(2) min, much shorter than typical for such a relatively warm and prominent secondary spectrum. The H-alpha emission-line velocity is modulated at the same period and roughly opposite phase. Time-series photometry shows flickering superposed on a modulation with two humps per orbit, consistent with ellipsoidal variation of the secondary's light. QZ Ser is a second example of a relatively short-period dwarf nova with a surprisingly warm secondary. Model calculations suggest that the secondary is strongly enhanced in helium, and had already undergone significant nuclear evolution when mass transfer began. Several sodium absorption features in the secondary spectrum are unusually strong, which may indicate that the present-day surface was the site of CNO-cycle hydrogen burning in the past.Comment: 11 pages, 3 postscript figures, 1 jpeg greyscale figure. Accepted for publication in PAS

Spectroscopy of Seven Cataclysmic Variables with Periods Above Five Hours

We present spectroscopy of seven cataclysmic variable stars with orbital periods P(orb) greater than 5 hours, all but one of which are known to be dwarf novae. Using radial velocity measurements we improve on previous orbital period determinations, or derive periods for the first time. The stars and their periods are TT Crt, 0.2683522(5) d; EZ Del, 0.2234(5) d; LL Lyr, 0.249069(4) d; UY Pup, 0.479269(7) d; RY Ser, 0.3009(4) d; CH UMa, 0.3431843(6) d; and SDSS J081321+452809, 0.2890(4) d. For each of the systems we detect the spectrum of the secondary star, estimate its spectral type, and derive a distance based on the surface brightness and Roche lobe constraints. In five systems we also measure the radial velocity curve of the secondary star, estimate orbital inclinations, and where possible estimate distances based on the MV(max) vs.P(orb) relation found by Warner. In concordance with previous studies, we find that all the secondary stars have, to varying degrees, cooler spectral types than would be expected if they were on the main sequence at the measured orbital period.Comment: 25 pages, 2 figures, accepted for Publications of the Astronomical Society of the Pacifi

1RXS J232953.9+062814: A Dwarf Nova with a 64-minute Orbital Period and a Conspicuous Secondary Star

We present spectroscopy and time-series photometry of the newly discovered dwarf nova 1RXS J232953.9+062814. Photometry in superoutburst reveals a superhump with a period of 66.06(6) minutes. The low state spectrum shows Balmer and HeI emission on a blue continuum, and in addition shows a rich absorption spectrum of type K4 +- 2. The absorption velocity is modulated sinusoidally at P_orb = 64.176(5) min, with semi-amplitude K = 348(4) km/s. The low-state light curve is double-humped at this period, and phased as expected for ellipsoidal variations. The absorption strength does not vary appreciably around the orbit. The orbital period is shorter than any other cataclysmic variable save for a handful of helium-star systems and V485 Centauri (59 minutes). The secondary is much hotter than main sequence stars of similar mass, but is well-matched by helium-enriched models, indicating that the secondary evolved from a more massive progenitor. A preliminary calculation in which a 1.2 solar-mass star begins mass transfer near the end of H burning matches this system's characteristics remarkably well.Comment: accepted to Astrophysical Journal Letters; 14 pages, 3 eps figures + 1 jpg greyscale figur

Five Dwarf Novae with Orbital Periods Below Two Hours

We give mean spectra and report orbital periods Porb based on radial velocities taken near minimum light for five dwarf novae, all of which prove to have Porb less than 2 hr. The stars and their periods are KX Aql, 0.06035(3) d; FT Cam, 0.07492(8) d; PU CMa, 0.05669(4) d; V660 Her, 0.07826(8) d;, and DM Lyr, 0.06546(6). The emission lines in KX Aql are notably strong and broad, and the other stars' spectra appear generally typical for short-period dwarf novae. We observed FT Cam, PU CMa, and DM Lyr on more than one observing run and constrain their periods accordingly. Differential time-series photometry of FT Cam shows strong flickering but rules out deep eclipses. Although dwarf novae in this period range generally show the superhumps and superoutbursts characteristic of the SU UMa subclass of dwarf novae, none of these objects have well-observed superhumps.Comment: 14 pages, three figures. Accepted for PAS

Superhumps in Cataclysmic Binaries. XXIII. V442 Ophiuchi and RX J1643.7+3402

We report the results of long observing campaigns on two novalike variables: V442 Ophiuchi and RX J1643.7+3402. These stars have high-excitation spectra, complex line profiles signifying mass loss at particular orbital phases, and similar orbital periods (respectively 0.12433 and 0.12056 d). They are well-credentialed members of the SW Sex class of cataclysmic variables. Their light curves are also quite complex. V442 Oph shows periodic signals with periods of 0.12090(8) and 4.37(15) days, and RX J1643.7+3402 shows similar signals at 0.11696(8) d and 4.05(12) d. We interpret these short and long periods respectively as a "negative superhump" and the wobble period of the accretion disk. The superhump could then possibly arise from the heating of the secondary (and structures fixed in the orbital frame) by inner-disk radiation, which reaches the secondary relatively unimpeded since the disk is not coplanar. At higher frequencies, both stars show another type of variability: quasi-periodic oscillations (QPOs) with a period near 1000 seconds. Underlying these strong signals of low stability may be weak signals of higher stability. Similar QPOs, and negative superhumps, are quite common features in SW Sex stars. Both can in principle be explained by ascribing strong magnetism to the white dwarf member of the binary; and we suggest that SW Sex stars are borderline AM Herculis binaries, usually drowned by a high accretion rate. This would provide an ancestor channel for AM Hers, whose origin is still mysterious.Comment: PDF, 41 pages, 4 tables, 16 figures; accepted, in press, to appear December 2002, PASP; more info at http://cba.phys.columbia.edu

The Glial Regenerative Response to Central Nervous System Injury Is Enabled by Pros-Notch and Pros-NFκB Feedback

Organisms are structurally robust, as cells accommodate changes preserving structural integrity and function. The molecular mechanisms underlying structural robustness and plasticity are poorly understood, but can be investigated by probing how cells respond to injury. Injury to the CNS induces proliferation of enwrapping glia, leading to axonal re-enwrapment and partial functional recovery. This glial regenerative response is found across species, and may reflect a common underlying genetic mechanism. Here, we show that injury to the Drosophila larval CNS induces glial proliferation, and we uncover a gene network controlling this response. It consists of the mutual maintenance between the cell cycle inhibitor Prospero (Pros) and the cell cycle activators Notch and NFκB. Together they maintain glia in the brink of dividing, they enable glial proliferation following injury, and subsequently they exert negative feedback on cell division restoring cell cycle arrest. Pros also promotes glial differentiation, resolving vacuolization, enabling debris clearance and axonal enwrapment. Disruption of this gene network prevents repair and induces tumourigenesis. Using wound area measurements across genotypes and time-lapse recordings we show that when glial proliferation and glial differentiation are abolished, both the size of the glial wound and neuropile vacuolization increase. When glial proliferation and differentiation are enabled, glial wound size decreases and injury-induced apoptosis and vacuolization are prevented. The uncovered gene network promotes regeneration of the glial lesion and neuropile repair. In the unharmed animal, it is most likely a homeostatic mechanism for structural robustness. This gene network may be of relevance to mammalian glia to promote repair upon CNS injury or disease

Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors

Background: Limits on the frequency of whole blood donation exist primarily to safeguard donor health. However, there is substantial variation across blood services in the maximum frequency of donations allowed. We compared standard practice in the UK with shorter inter-donation intervals used in other countries. Methods: In this parallel group, pragmatic, randomised trial, we recruited whole blood donors aged 18 years or older from 25 centres across England, UK. By use of a computer-based algorithm, men were randomly assigned (1:1:1) to 12-week (standard) versus 10-week versus 8-week inter-donation intervals, and women were randomly assigned (1:1:1) to 16-week (standard) versus 14-week versus 12-week intervals. Participants were not masked to their allocated intervention group. The primary outcome was the number of donations over 2 years. Secondary outcomes related to safety were quality of life, symptoms potentially related to donation, physical activity, cognitive function, haemoglobin and ferritin concentrations, and deferrals because of low haemoglobin. This trial is registered with ISRCTN, number ISRCTN24760606, and is ongoing but no longer recruiting participants. Findings: 45 263 whole blood donors (22 466 men, 22 797 women) were recruited between June 11, 2012, and June 15, 2014. Data were analysed for 45 042 (99·5%) participants. Men were randomly assigned to the 12-week (n=7452) versus 10-week (n=7449) versus 8-week (n=7456) groups; and women to the 16-week (n=7550) versus 14-week (n=7567) versus 12-week (n=7568) groups. In men, compared with the 12-week group, the mean amount of blood collected per donor over 2 years increased by 1·69 units (95% CI 1·59–1·80; approximately 795 mL) in the 8-week group and by 0·79 units (0·69–0·88; approximately 370 mL) in the 10-week group (p<0·0001 for both). In women, compared with the 16-week group, it increased by 0·84 units (95% CI 0·76–0·91; approximately 395 mL) in the 12-week group and by 0·46 units (0·39–0·53; approximately 215 mL) in the 14-week group (p<0·0001 for both). No significant differences were observed in quality of life, physical activity, or cognitive function across randomised groups. However, more frequent donation resulted in more donation-related symptoms (eg, tiredness, breathlessness, feeling faint, dizziness, and restless legs, especially among men [for all listed symptoms]), lower mean haemoglobin and ferritin concentrations, and more deferrals for low haemoglobin (p<0·0001 for each) than those observed in the standard frequency groups. Interpretation: Over 2 years, more frequent donation than is standard practice in the UK collected substantially more blood without having a major effect on donors' quality of life, physical activity, or cognitive function, but resulted in more donation-related symptoms, deferrals, and iron deficiency. Funding: NHS Blood and Transplant, National Institute for Health Research, UK Medical Research Council, and British Heart Foundation

The role of ethnicity in the attainment and experiences of graduates in distance education

In the UK, the attainment of White graduates (as measured by the class of honours that they have been awarded) tends to be higher than that of graduates from other ethnic groups. This is apparent, in particular, in graduates who have taken courses by distance learning with the Open University. Analysis of data from Open University graduates over three successive years yielded no evidence that the latter trend could be attributed to confounded demographic variables. A postal survey found little variation in perceptions of academic quality or reports of personal development among Open University graduates from different ethnic groups. Quantitative variations in the attainment of graduates from different ethnic groups are not necessarily reflected in qualitative variations in their experience of distance education

Location of Pathogenic Bacteria during Persistent Infections: Insights from an Analysis Using Game Theory

Bacterial persistent infections are responsible for a significant amount of the human morbidity and mortality. Unlike acute bacterial infections, it is very difficult to treat persistent bacterial infections (e.g. tuberculosis). Knowledge about the location of pathogenic bacteria during persistent infection will help to treat such conditions by designing novel drugs which can reach such locations. In this study, events of bacterial persistent infections were analyzed using game theory. A game was defined where the pathogen and the host are the two players with a conflict of interest. Criteria for the establishment of Nash equilibrium were calculated for this game. This theoretical model, which is very simple and heuristic, predicts that during persistent infections pathogenic bacteria stay in both intracellular and extracellular compartments of the host. The result of this study implies that a bacterium should be able to survive in both intracellular and extracellular compartments of the host in order to cause persistent infections. This explains why persistent infections are more often caused by intracellular pathogens like Mycobacterium and Salmonella. Moreover, this prediction is in consistence with the results of previous experimental studies