Increased Vesicular Monoamine Transporter 2 (VMAT2) and Dopamine Transporter (DAT) Expression in Adolescent Brain Development: A Longitudinal Micro-PET/CT Study in Rodent

Background: Brain development and maturation in adolescence is a complex process with active changes of metabolic and neurotransmission pathways. Positron emission tomography (PET) is a useful imaging modality for tracking metabolic and functional changes in adolescent brain. In this study, changes of glucose metabolism, expression of vesicular monoamine transporter 2 and dopamine transporter during adolescent brain development in rats were investigated with PET/CT.Methods: A longitudinal PET/CT study of age-dependent changes of VMAT2, DAT and glucose metabolism in adolescent brain was conducted in a group of Wistar rats (n = 6) post sequential intravenous injection of 18F-PF-(+)-DTBZ, 11C-CFT, and 18F-FDG, respectively. PET acquisition was performed at 2, 4, 9, and 12 months of age. Radiotracer uptake in different brain regions, including the striatum, cerebellum, and hippocampus, were quantified and recorded as Standardized uptake value (SUV) and striatal specific uptake ratio (SUVR: SUV in brain regions/SUV in cerebellum).Results: Variable uptake of 18F-PF-(+)-DTBZ and 11C-CFT were detected, with highest level uptake in the striatum and accumbens. There was significant age-dependent increase of 18F-PF-(+)-DTBZ and 11C-CFT uptake in the striatum from 2 months of age (SUV: 1.36 ± 0.22, 1.37 ± 0.39, respectively), to 4 months (SUV: 2.22 ± 0.29, 2.04 ± 0.33), 9 months (1.98 ± 0.34, 2.09 ± 0.18), 12 months (SUV: 1.93 ± 0.19, 2.00 ± 0.17) of age, SUV of 18F-FDG also increased from 2 months of age to older ages (SUV in the striatum: 3.71 ± 0.78 at 2 month, 5.28 ± 0.81, 5.14 ± 0.73, 4.94 ± 0.50 at 4, 9, 12 month, respectively).Conclusion: Age-dependent increases of striatal of 18F-FDG, 18F-PF-(+)-DTBZ, and 11C-CFT uptake were detected in rats from 2 to 4 month of age, demonstrating striatal development presents over the first 4 months of age. Four months of age can be considered a safe threshold to launch brain disease studies for exclusion of confusion of continuing tissue development. These findings support further investigation of age-dependent changes in expression of DAT, VMAT2, and glucose metabolism for their potential use as a new imaging biomarker for study of brain development and functional maturation

Household Livelihood Strategy Choices, Impact Factors, and Environmental Consequences in Miyun Reservoir Watershed, China

Household livelihood strategies are embedded in the natural and socioeconomic contexts in which people live. Analyzing the factors that influence household livelihood choice and defining their consequences can be beneficial for informing rural household policies. In turn, this has great significance for fostering sustainable livelihood strategies. We grouped household livelihood strategies based on the income distribution of 756 households and analyzed their influencing factors and possible livelihood consequences in the watershed of Miyun Reservoir, the only source of surface water currently available for domestic use in Beijing, China. Local farmers’ livelihood strategies can be grouped into three types: farming, local off-farm, and labor-migrant. Farming households have the lowest livelihood capitals, other than natural capital, compared with labor-migrant households and off-farm households, the latter having better livelihood capital status. Geographical location, natural capital, household structure, labor quality, and ecological policies are the main factors affecting farmers’ choice of livelihood strategy. Local off-farm households have a significantly lower dependency on firewood, land resources, and investment than that of farming and labor-migrant households, and have the highest reliance on fossil fuel. This household classification can help us understand the livelihood characteristics, impact factors, and consequences of different types of household strategies, which also suggest tailored policy and management options to promote sustainable livelihoods based on different household types

Classification of the Relationship between Household Welfare and Ecosystem Reliance in the Miyun Reservoir Watershed, China

Household welfare is inseparable from the environment because of its dependence on ecosystems and their services. However, linking household welfare and ecosystems in order to inform differentiated household livelihood development in spatially heterogeneous regions is still a great challenge. Based on a field survey of 1754 households, we grouped the relationships between household welfare (defined by total income) and ecosystem reliance (expressed by an index of dependence on ecosystem services) in the Watershed of Miyun Reservoir, the only source of surface water for domestic use in Beijing, China. The relationships can be grouped into four types: high welfare and high dependency; low welfare and low dependency; high welfare and low dependence; and low welfare and high dependency. Family structure, households’ education and skill level, and the proximity to Beijing have significant impacts on household welfare, while the quantity of natural capital and eco-compensation fund significantly contribute to the ecosystem dependence. Maintaining suitable family size and age structure, improving education and skill levels, and strengthening payment for ecosystem services within low welfare households would be effective approaches to their welfare improvement. The above classification can help design tailored policy and management options to promote sustainable livelihoods based on different household subgroups

Telecoupled Sustainable Livelihoods in an Era of Rural–Urban Dynamics: The Case of China

Recently, increasingly sophisticated studies have investigated the relationship between agrarian livelihoods and the environment, as well as rural–urban interactions in developing countries. The policies developed to respond to these dynamics can constrain livelihood options or provide additional opportunities. In the present study, using a modified version of the telecoupled sustainable livelihood framework to generalize dynamic livelihood strategies in the context of rural–urban transformation and by focusing on recent research in China, we review important factors that shape rural livelihood strategies as well as the types of strategies that typically intersect with livelihood and environmental dynamics. We then examine telecoupled rural–urban linkages given that the dynamics of the livelihood strategies of farmers can cause flows of labor, capital, ecosystem services, and other processes between rural and urban areas, thereby placing livelihood strategies in a dynamic context, which has not been considered widely in previous research. We show that most previous studies focused on the reduction of environmental impacts via livelihood diversification and rural–urban migration. We propose several areas for future policy development and research

Clinical Characteristics of Cerebral Venous Sinus Thrombosis in Patients with Systemic Lupus Erythematosus: A Single-Centre Experience in China

Clinical characteristics of systemic lupus erythematosus (SLE) patients complicated with cerebral venous sinus thrombosis (CVST) between 2000 and 2013 were analyzed through this retrospective, single-centre study. Of 4747 hospitalized SLE patients, 17 (0.36%, 12 females, average age 30) had CVST. Headache (88.2%) was the most common neurological symptom followed by nausea or vomiting (47.1%), conscious disturbance (41.2%), edema of eyelids or conjunctiva (35.3%), blurred vision or diplopia (35.3%), and seizure (35.3%). Increased intracranial pressure (ICP) occurred in 13 cases (76.5%). Magnetic resonance venography (MRV) detected thrombosis in the transverse (82.4%), sigmoid (52.9%), and sagittal (35.3%) sinuses, with frequent (70.6%) multiple sinus occlusions. Compared to SLE patients without CVST, SLE patients with CVST had a higher prevalence of thrombocytopenia and positive antiphospholipid antibodies and a higher SLE disease activity index (SLEDAI) score. 13 patients achieved improvement following glucocorticoids and immunosuppressants treatment, as well as anticoagulants, while 3 patients died at the hospital. CVST is relatively rare in SLE and tends to occur in active lupus patients. Intracranial hypertension is common but nonspecific clinical feature, so MRV evaluation is necessary to establish a diagnosis. Aggressive treatment for the rapid control of SLE activity combined with anticoagulants can improve the prognosis

Cardiac involvement in patients with primary biliary cholangitis: A 14-year longitudinal survey-based study.

Patients with primary biliary cholangitis (PBC) can have extrahepatic manifestations. However, data about cardiac involvement of PBC is limited. We aimed in this study to analyze the clinical characteristics in patients with PBC complicated with and without cardiac involvement, and the risk factors of cardiac involvement in PBC. PBC patients admitted to Peking Union Medical College Hospital between January 2002 and February 2016 were consecutively enrolled. Structured interview, systemic rheumatologic examination, and laboratory tests were conducted for each patient, and risk factors of cardiac involvement were analyzed by comparing patients with and without cardiac involvement. In total, 580 PBC patients were enrolled, and cardiac involvement was identified in 24 patients (4%), with 11 male (46%) and a mean age of 57±8 year. Cardiomyopathy and arrhythmias were presented in 17 (70.8%) and 21 (87.5%) patients, respectively. Patients with cardiac involvement were more frequently male (46% vs. 11%, P<0.01), complicated with inflammatory myopathy (IM) (58% vs. 1%, P<0.01), and had a longer disease course (median, 72 vs 24 month, P<0.01). Furthermore, concomitant IM was the independent risk factor of cardiac involvement in PBC (OR = 77.333, 95% CI: 23.704-252.294). Cardiac involvement was a rare complication of PBC, which was more frequently observed in male or long-course patients. Importantly, concomitant IM was the strong independent risk factor of cardiac involvement in PBC. Given cardiac involvement is a serious complication, thorough evaluation of cardiac manifestation in high-risk PBC patients is highly recommended

Magnetic properties and high frequency characteristics of isotropic FeCoZr thin films with stripe domains

Magnetic properties and high frequency characteristicsof (Fe70.6Co29.4)100−xZrx (x = 4.0 − 18.2 at.%) thin　films have been investigated. The saturation magnetization　4πMs decreases continuously from 21.7 kGs for x = 4.0 at.%　to 12.2 kGs for x = 18.2 at.% and it is consistent with the　decreasing of Fe-Co composition. It is found that the filmsshow nearly isotropic magnetic behavior in the film plane　for the Zr content ranging from 7.2 to 18.2 at.%. These films　exhibit a weak perpendicular magnetic anisotropy with coercivity　values of 24–67 Oe. Meanwhile, the in-plane isotropic　FeCoZr films show a good high frequency response of permeability.　In particular, the film with x = 7.2 at.% shows a　resonance frequency of 2.8 GHz along the direction perpendicular　to the stripe domain axis. The permeability spectra　of the thin films with higher Zr content display multiple　resonance peaks, which may be due to the perpendicular　magnetic anisotropy induced by the stress