A review of stress-induced hyperglycaemia in the context of acute ischaemic stroke: Definition, underlying mechanisms, and the status of insulin therapy

The transient elevation of blood glucose produced following acute ischaemic stroke (AIS) has been described as stress-induced hyperglycaemia (SIH). SIH is common even in patients with AIS who have no previous diagnosis of diabetes mellitus. Elevated blood glucose levels during admission and hospitalization are strongly associated with enlarged infarct size and adverse prognosis in AIS patients. However, insulin-intensive glucose control therapy defined by admission blood glucose for SIH has not achieved the desired results, and new treatment ideas are urgently required. First, we explore the various definitions of SIH in the context of AIS and their predictive value in adverse outcomes. Then, we briefly discuss the mechanisms by which SIH arises, describing the dual effects of elevated glucose levels on the central nervous system. Finally, although preclinical studies support lowering blood glucose levels using insulin, the clinical outcomes of intensive glucose control are not promising. We discuss the reasons for this phenomenon

Intrinsic nonlinear Hall effect and gate-switchable Berry curvature sliding in twisted bilayer graphene

Though the observation of quantum anomalous Hall effect and nonlocal transport response reveals nontrivial band topology governed by the Berry curvature in twisted bilayer graphene, some recent works reported nonlinear Hall signals in graphene superlattices which are caused by the extrinsic disorder scattering rather than the intrinsic Berry curvature dipole moment. In this work, we report a Berry curvature dipole induced intrinsic nonlinear Hall effect in high-quality twisted bilayer graphene devices. We also find that the application of the displacement field substantially changes the direction and amplitude of the nonlinear Hall voltages, as a result of a field-induced sliding of the Berry curvature hotspots. Our work not only proves that the Berry curvature dipole could play a dominant role in generating the intrinsic nonlinear Hall signal in graphene superlattices with low disorder densities, but also demonstrates twisted bilayer graphene to be a sensitive and fine-tunable platform for second harmonic generation and rectification

Carbonized Cow Dung as a High Performance and Low Cost Anode Material for Bioelectrochemical Systems

We develop a high-performance anode formed from carbonized cow dung for bioelectrochemical systems. Thermal gravimetric analysis showed that the CD carbonization process started at 300°C and ended at approximately 550°C; the weight was reduced by 51%. After a heat-treatment at 800°C for 2 h, the treated CD featured a good conductivity and a high specific surface area. The maximum current density of 11.74 ± 0.41 A m-2 was achieved by CD anode (heated at 800°C), which remained relatively stable from more than 10 days. This study shows that a valuable anode material can be produced through conversion of CD by high-temperature carbonization. This approach provides a new way to alleviate environmental problems associated with CD

Sodium-Glucose Cotransporter 2 Inhibitors and the Risk of Pneumonia and Septic Shock

CONTEXT: Individuals with type 2 diabetes mellitus (DM) have an increased risk of pneumonia and septic shock. Traditional glucose-lowering drugs have recently been found to be associated with a higher risk of infections. It remains unclear whether sodium-glucose cotransporter 2 inhibitors (SGLT2is), which have pleiotropic/anti-inflammatory effects, may reduce the risk of pneumonia and septic shock in DM. METHODS: MEDLINE, Embase, and ClinicalTrials.gov were searched from inception up to May 19, 2022, for randomized, placebo-controlled trials of SGLT2i that included patients with DM and reported outcomes of interest (pneumonia and/or septic shock). Study selection, data extraction, and quality assessment (using the Cochrane Risk of Bias Assessment Tool) were conducted by independent authors. A fixed-effects model was used to pool the relative risk (RRs) and 95% CI across trials. RESULTS: Out of 4568 citations, 26 trials with a total of 59 264 patients (1.9% developed pneumonia and 0.2% developed septic shock) were included. Compared with placebo, SGLT2is significantly reduced the risk of pneumonia (pooled RR 0.87, 95% CI 0.78-0.98) and septic shock (pooled RR 0.65, 95% CI 0.44-0.95). There was no significant heterogeneity of effect size among trials. Subgroup analyses according to the type of SGLT2i used, baseline comorbidities, glycemic control, duration of DM, and trial follow-up showed consistent results without evidence of significant treatment-by-subgroup heterogeneity (all P(heterogeneity) > .10). CONCLUSION: Among DM patients, SGLT2is reduced the risk of pneumonia and septic shock compared with placebo. Our findings should be viewed as hypothesis generating, with concepts requiring validation in future studies

Adenoid lymphocyte heterogeneity in pediatric adenoid hypertrophy and obstructive sleep apnea

IntroductionAdenoid hypertrophy is the main cause of obstructive sleep apnea in children. Previous studies have suggested that pathogenic infections and local immune system disorders in the adenoids are associated with adenoid hypertrophy. The abnormalities in the number and function of various lymphocyte subsets in the adenoids may play a role in this association. However, changes in the proportion of lymphocyte subsets in hypertrophic adenoids remain unclear.MethodsTo identify patterns of lymphocyte subsets in hypertrophic adenoids, we used multicolor flow cytometry to analyze the lymphocyte subset composition in two groups of children: the mild to moderate hypertrophy group (n = 10) and the severe hypertrophy group (n = 5).ResultsA significant increase in naïve lymphocytes and a decrease in effector lymphocytes were found in severe hypertrophic adenoids.DiscussionThis finding suggests that abnormal lymphocyte differentiation or migration may contribute to the development of adenoid hypertrophy. Our study provides valuable insights and clues into the immunological mechanism underlying adenoid hypertrophy

Cassava genome from a wild ancestor to cultivated varieties

Cassava is a major tropical food crop in the Euphorbiaceae family that has high carbohydrate production potential and adaptability to diverse environments. Here we present the draft genome sequences of a wild ancestor and a domesticated variety of cassava and comparative analyses with a partial inbred line. We identify 1,584 and 1,678 gene models specific to the wild and domesticated varieties, respectively, and discover high heterozygosity and millions of single-nucleotide variations. Our analyses reveal that genes involved in photosynthesis, starch accumulation and abiotic stresses have been positively selected, whereas those involved in cell wall biosynthesis and secondary metabolism, including cyanogenic glucoside formation, have been negatively selected in the cultivated varieties, reflecting the result of natural selection and domestication. Differences in microRNA genes and retrotransposon regulation could partly explain an increased carbon flux towards starch accumulation and reduced cyanogenic glucoside accumulation in domesticated cassava. These results may contribute to genetic improvement of cassava through better understanding of its biology

Optimal Configuration Method of Sampling Points Based on Variability of Sea Surface Temperature

In situ observation is one of the most direct and efficient ways to understand the ocean, but it is usually limited in terms of spatial and temporal coverage. The determination of optimal sampling strategies that effectively utilize available resources to maximize the information content of the collected ocean data is becoming an open problem. The historical sea surface temperature (SST) dataset contains the spatial variability information of SST, and this prior knowledge can be used to optimize the configuration of sampling points. Here, a configuration method of sampling points based on the variability of SST is studied. Firstly, in order to get the spatial variability of SST in the ocean field to be sampled, the historical SST data of the field is analyzed. Then, K-means algorithm is used to cluster the subsampled fields to make the configuration of sampling points more suitable. Finally, to evaluate the sampling performance of the new configuration method of sampling points, the SST field is reconstructed by the method based on compression sensing algorithm. Results show that the proposed optimal configuration method of sampling points significantly outperforms the traditional random sampling points distribution method in terms of reconstruction accuracy. These results provide a new method for configuring sampling points of ocean in situ observation with limited resources

Research on the Application of Multi-Source Data Analysis for Bridge Safety Monitoring in the Reconstruction and Demolition Process

With the increase of bridge-required demolition/dismantling for reconstruction or modification, the early warning of construction emergencies is greatly needed for monitoring the structural safety of bridges under construction. In this paper, based on the multi-source data of nearby construction and demolition construction of a large-span RC arch bridge in China, the Analytic Hierarchy Process (AHP) method is adopted to analyze the multi-source data and set the early warning threshold for bridge safety in construction. According to the analytical results, a reasonable evaluation of AHP factors can improve the accuracy and timeliness of safety early warning in the structural safety monitoring of bridges during the construction process. The weight of the monitoring data in AHP should be assigned according to its reliability, stability, and importance. Bridge safety assessment of nearby construction having harmful vibration should prioritize dynamic bridge monitoring by cooperating with multi-source data, including stress, and deformation monitoring of the bridge is necessary. The assessment results proved that multi-source data, including but not limited to structural stress and deformation monitoring data, vibration data, theoretical prediction data, environment data such as temperature data, and construction/maintenance history data, are necessary for safety monitoring and early warning of construction with specifications related to bridge construction. The early warnings triggered by the evaluation results successfully ensure the safety status of the bridge during nearby construction and demolition construction, which shows the proposed method can provide a guideline for comprehensively evaluating and early warning of the status of bridge construction