The Construction of Ecological Management System of Urban Lakes：A Case Study of Wuhan

This paper clearly sorts out the construction process of ecological management system of urban lakes in Wuhan by analyzing its three progressive phases. The ecological management system of urban lakes refers to the ecological management system dedicated to lake protection and ecosystem restoration. The management behavior of this system emphasizes the construction of the entirety and the systematicity of the lake areas, and it also highly concerns about the sustainable development of the regional economy and ecology as well as the widespread participation of the public and the stakeholders. Urban ecological management system based on an ecological treatment diagram with polyhydric cooperation allows urban lakes to fairly and sustainably meet the objectives and requirements of the ecosystem and human beings and ultimately achieves the “healthy ecological governance” of urban lakes.

New Reflection on Undergraduate Teaching System Construction of Landscape in Art Colleges

By the end of 2012, the undergraduate course catalog in colleges and universities has expressly stipulated that landscape architecture majors can be granted Bachelor of Arts. The promulgation of this provision not only laid the academic foundation of landscape profession (landscape architecture) but pointed out the future direction of landscape architecture for art colleges. According to the unique academic characteristics of art colleges, the authors in this paper put forward three suggestions on constructing undergraduate teaching of landscape architecture in art colleges, in hope that people with lofty ideals would pay more attention to exploring the construction of characteristic landscape architecture for art colleges under the new situation

Circ_0000284 facilitates the growth, metastasis and glycolysis of intrahepatic cholangiocarcinoma through miR-152-3p-mediated PDK1 expression

Background. Circular RNAs (circRNAs) are key molecules in the regulation of intrahepatic cholangiocarcinoma (ICC) progression. The purpose of this study was to analyze the function and underlying molecular mechanism of circ_0000284 in ICC. Methods. Quantitative real-time PCR was used to analyze the circ_0000284, microRNA (miR)-152-3p and pyruvate dehydrogenase kinase 1 (PDK1) expression. Cell proliferation, apoptosis, invasion and migration were executed by cell counting kit 8 assay, EdU assay, flow cytometry, transwell assay and wound healing assay, respectively. All protein expression levels were examined using western blot analysis. Cell glycolysis was analyzed by detecting glucose consumption, lactate production and ATP/ADP ratios. Target relationship was estimated by dual-luciferase reporter assay. The effect of circ_0000284 on ICC tumor growth in vivo was evaluated by constructing xenograft mice model. Results. We detected high expression of circ_0000284 in ICC tumor tissues and cells. Downregulated circ_0000284 inhibited ICC cell proliferation, invasion, migration, glycolysis, and accelerated apoptosis. MiR-152-3p was sponged by circ_0000284, and its inhibitor revoked the effect of circ_0000284 knockdown on ICC cell progression. PDK1 was a target of miR-152-3p, and its expression was suppressed by circ_0000284 knockdown. PDK1 overexpression reversed the inhibition effect of miR-152-3p on ICC cell growth, metastasis and glycolysis. In animal experiments, circ_0000284 downregulation also inhibited ICC tumor growth. Conclusion. Circ_0000284 promoted the growth, metastasis and glycolysis of ICC by miR-152-3p/PDK1 pathway, showing that circ_0000284 was a potential therapeutic target for ICC

Biomechanical Analysis of the Fixation System for T-Shaped Acetabular Fracture

This study aims to evaluate the biomechanical mechanism of fixation systems in the most frequent T-shaped acetabular fracture using finite element method. The treatment of acetabular fractures was based on extensive clinical experience. Three commonly accepted rigid fixation methods (double column reconstruction plates (P × 2), anterior column plate combined with posterior column screws (P + PS), and anterior column plate combined with quadrilateral area screws (P + QS)) were chosen for evaluation. On the basis of the finite element model, the biomechanics of these fixation systems were assessed through effective stiffness levels, stress distributions, force transfers, and displacements along the fracture lines. All three fixation systems can be used to obtain effective functional outcomes. The third fixation system (P + QS) was the optimal method for T-shaped acetabular fracture. This fixation system may reduce many of the risks and limitations associated with other fixation systems

Di-tert-butyl­chlorido(pyrrolidine-1-dithio­carboxyl­ato-κ2 S,S′)tin(IV)

The title compound, [Sn(C4H9)2(C5H8NS2)Cl], contains two mol­ecules in the asymmetric unit, with similar conformations. In both mol­ecules, the Sn atom adopts a distorted trigonal-bipyramidal geometry arising from two C atoms, one Cl atom and two S atoms from the bidentate dithio­carbamate ligand, with one Sn—S bond much longer than the other. One C atom of the pyrrolidine ring is disordered equally over two sites

Influence Maximization with Novelty Decay in Social Networks

Influence maximization problem is to find a set of seed nodes in a social network such that their influence spread is maximized under certain propagation models. A few algorithms have been proposed for solving this problem. However, they have not considered the impact of novelty decay on influence propagation, i.e., repeated exposures will have diminishing influence on users. In this paper, we consider the problem of influence maximization with novelty decay (IMND). We investigate the effect of novelty decay on influence propagation on real-life datasets and formulate the IMND problem. We further analyze the problem properties and propose an influence estimation technique. We demonstrate the performance of our algorithms on four social networks

Rabbit Meat—Production, Consumption and Consumers’ Attitudes and Behavior

Rabbit meat could play an important role in health, the rural economy, and sustainable development. Rabbit meat has excellent nutritional features, such as high protein content, low-fat content, and a high percentage of unsaturated fatty acids, low cholesterol and sodium levels. In addition, rabbit meat production contributes to maintaining economic activities in rural marginal areas. However, the consumption of rabbit meat is still limited due to several factors such as the higher cost of commercial food that is slowing down rabbits’ breeding. Socio-demographic characteristics, attitudes, and nationality of consumers influence the demand and consumption of rabbit meat. The social and economic changes of the past years are leading to an increased interest in rabbit meat products with convenience characteristics. Consumers are also increasingly paying attention to animal husbandry methods for health concerns and ethical reasons. This paper presents an overview of rabbit meat focusing on production, nutritional composition, consumers’ preferences, and marketing. The review proposes strategies that, coupled with information campaigns could improve consumers’ knowledge of the positive characteristics of rabbit meat, which would contribute to the market development

Dissecting the target specificity of RNase H recruiting oligonucleotides using massively parallel reporter analysis of short RNA motifs

Processing and post-transcriptional regulation of RNA often depend on binding of regulatory molecules to short motifs in RNA. The effects of such interactions are difficult to study, because most regulatory molecules recognize partially degenerate RNA motifs, embedded in a sequence context specific for each RNA. Here, we describe Library Sequencing (LibSeq), an accurate massively parallel reporter method for completely characterizing the regulatory potential of thousands of short RNA sequences in a specific context. By sequencing cDNA derived from a plasmid library expressing identical reporter genes except for a degenerate 7mer subsequence in the 3′UTR, the regulatory effects of each 7mer can be determined. We show that LibSeq identifies regulatory motifs used by RNA-binding proteins and microRNAs. We furthermore apply the method to cells transfected with RNase H recruiting oligonucleotides to obtain quantitative information for >15000 potential target sequences in parallel. These comprehensive datasets provide insights into the specificity requirements of RNase H and allow a specificity measure to be calculated for each tested oligonucleotide. Moreover, we show that inclusion of chemical modifications in the central part of an RNase H recruiting oligonucleotide can increase its sequence-specificity

A two-dimensional hybrid with molybdenum disulfide nanocrystals strongly coupled on nitrogen-enriched graphene via mild temperature pyrolysis for high performance lithium storage

A novel 2D hybrid with MoS₂ nanocrystals strongly coupled on nitrogen-enriched graphene (MoS₂/NGg-C₃N₄) is realized by mild temperature pyrolysis (550 °C) of a self-assembled precursor (MoS₃/g-C₃N₄–H⁺/GO). With rich active sites, the boosted electronic conductivity and the coupled structure, MoS₂/NGg₋C₃N₄ achieves superior lithium storage performance