The role of IL-1 gene polymorphisms (IL1A, IL1B, and IL1RN) as a risk factor in unsuccessful implants retaining overdentures

Purpose: Implant-supported overdentures are an alternative predictable rehabilitation method that has a high impact on improving the patient's quality of life. However, some biological complications may interfere with the maintenance and survival of these overdenture implants. The goal of this article was to assess the factors that affect periimplant success, through a hypothetical prediction model for biological complications of implant overdentures.Methods: A retrospective observational, prevalence study was conducted in 58 edentulous Caucasian patients rehabilitated with implant overdentures. A total of 229 implants were included in the study. Anamnestic, clinical, and implant-related parameters were collected and recorded in a single database. "Patient" was chosen as the unit of analysis, and a complete screening protocol was established. The data analytical study included assessing the odds ratio, concerning the presence or absence of a particular risk factor, by using binary logistic regression modeling. Probability values (p values) inferior to 0.05 were considered as representing statistically significant evidence.Results: The performed prediction model included the following variables: mean probing depth, metal exposure, IL1B_allele2, maxillary edentulousness, and Fusobacterium nucleatum. The F. nucleatum showed significant association with the outcome. Introducing a negative coefficient appeared to prevent complications or even boost the biological defense when associated with other factors.Conclusions: The prediction model developed in this study could serve as a basis for further improved models that would assist clinicians in the daily diagnosis and treatment planning practice of oral rehabilitation with implant overdentures.info:eu-repo/semantics/publishedVersio

Treatment of peri-implantitis by local delivery of tetracycline: Clinical, microbiological and radiological results

The purpose of this study was to investigate the clinical, microbiological and radiological effects of peri-implantitis therapy by local delivery of tetracycline. In 25 partially edentulous patients, 30 implants with radiographic evidence of circumferential bone loss, and peri-implant probing depths ≥5 mm were treated with polymeric tetracycline HCl-containing fibers. Clinical and microbial parameters were recorded at baseline, and 1, 3, 6, and 12 months (M) after treatment. Standardized radiographs were obtained at baseline, M3, and one year after treatment. Two patients were discontinued from the study after 180 days because of persisting active peri-implantitis with pus formation. The remaining subjects showed a significant decrease of mean peri-implant probing depth from 6.0 to 4.1 mm (M1, P<0.001), which was maintained over 12 months. In comparison to baseline, the bleeding tendency was significantly reduced after one month, and thereafter (P<0.001). No significant recession of the mucosal margin was noted. The radiologically determined distance from the shoulder of the implant to the bottom of the bony defect decreased slightly, but not significantly, from 5.2 to 4.9 mm. At M1, M3 and M6, mean total anaerobic cultivable bacterial counts were significantly lower than at baseline (P<0.001). A significant decrease in frequency of detection was noted for Prevotella intermedia/nigrescens, Fusobacterium sp., Bacteroides forsythus, and Campylobacter rectus (P<0.01). Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Eikenella corrodens had very low baseline frequencies that could not be significantly suppressed further. In conclusion, therapy of peri-implantitis by local delivery of tetracycline had a positive effect on clinical and microbiological parameters. Copyright © Munksgaard 2001.link_to_subscribed_fulltex

Smokers have a higher risk of inflammatory peri-implant disease than non-smokers

WOS: 000426520600008PubMed ID: 28800203AimTo comparatively evaluate peri-implant health status in smokers and non-smokers. Materials and MethodsA total of 142 implants (74 implants in non-smokers, 68 in smokers) in 43 smoker or non-smoker systemically healthy patients were included in the study. Demographic and clinical periodontal data were recorded and analysed by chi-square and Mann-Whitney U tests. ResultsPeri-implantitis and mucositis cases were significantly more frequent in the smokers than non-smokers (p=.001). Suppuration, bleeding and plaque scores around the implants were significantly higher in smokers than non-smokers (p=.001; p=.002; p<.0001, respectively). ConclusionThe present findings indicate that smokers have a higher risk of inflammatory peri-implant diseases. Therefore, more frequent recalls may be recommended in smokers with dental implants

An exploratory case-control study on the impact of IL-1 gene polymorphisms on early implant failure

Background: The association between IL-1 gene polymorphisms and peri-implantitis has been well documented. However, data on the association with early implant failure are scarce. Purpose: The objective of this case-control study was to explore the impact of IL-1A (−889), IL-1B (−511), and IL-1B (+3,954) gene polymorphisms on early implant failure in Caucasians. Materials and Methods: Between September 2004 and August 2007, 461 patients were treated with dental implants at the University Hospital in Ghent, Belgium. Fourteen subjects of this patient group who had experienced one or more early implant failures (within 6 months from implant installation) were recruited as “cases.” Fourteen “controls,” matched in terms of age, gender, and smoking habits, with only surviving implants, were selected from the same patient group. Allele and genotype analysis was performed on the basis of a blood sample by Sanger sequencing of polymerase chain reaction products containing the IL-1A (−889), IL-1B (−511), and IL-1B (+3,954) gene polymorphisms. Results: A significant impact of the IL-1A (−889) T allele (p = .039) and the IL-1B (+3,954) T allele (p = .003) on early implant failure was demonstrated (odds ratios = 3.9 and 15.0, respectively). In addition, the genotypic distribution differed significantly between cases and controls for IL-1B (+3,954) (p = .015). Conclusions: The IL-1B (+3,954) gene polymorphism seems to affect osseointegration. Additional case-control studies in larger patient groups are needed to confirm this observation

The French Educational System: Issues and Debates

This paper describes the main features of the French Educational system and analyses the ongoing controversies surrounding pre-elementary education, grade repetition, class size reduction or educational priority zones in France