実験的ウサギ下顎欠損のrhBMP-2とアテロコラーゲンゲルによる再構築 in vivo μCTによる観察と組織学的検索

A rabbit experimental mandibular defect was reconstructed with rhBMP-2 and atelocollagen gel, and examined using μCT (R_mCT, Rigaku Mechatronics, Tokyo) in vivo and histological techniques. Using eight rabbits, we made an experimental mandibular defect and filled it with 1% atelocollagen gel including rhBMP-2 10ìg (Astellas Pharma Inc.). In μCT observation, the density was slightly elevated at the bone marrow side at one week, and the phenomenon gradually expanded during the course of this experiment. Histologically, mesenchymal cell proliferation and immature bone formation occurred at one week, and mature bone gradually increased and filled in at four weeks.ウサギ8羽の下顎を実験的に欠損させ、欠損部位を組換えヒト骨形態発生蛋白を含む1%アテロコラーゲンゲルで満たした。1週間後にこの部位をμCTで観察したところ、密度が骨髄側で軽度上昇していた。この現象は経時的に広がっていくことが示された。組織学的検索では、1週間後に間葉細胞の増殖と未熟骨細胞の形成が認められ、4週間後には成熟細胞が徐々に増加して下顎欠損部位を満たしていた

Extraskeletal Ewing's sarcoma presenting with pulmonary embolism

Australasian Radiology402175-178AURD