8 research outputs found
Topological Analysis of Small Leucine-Rich Repeat Proteoglycan Nyctalopin
Nyctalopin is a small leucine rich repeat proteoglycan (SLRP) whose function is
critical for normal vision. The absence of nyctalopin results in the complete
form of congenital stationary night blindness. Normally, glutamate released by
photoreceptors binds to the metabotropic glutamate receptor type 6 (GRM6), which
through a G-protein cascade closes the non-specific cation channel, TRPM1, on
the dendritic tips of depolarizing bipolar cells (DBCs) in the retina.
Nyctalopin has been shown to interact with TRPM1 and expression of TRPM1 on the
dendritic tips of the DBCs is dependent on nyctalopin expression. In the current
study, we used yeast two hybrid and biochemical approaches to investigate
whether murine nyctalopin was membrane bound, and if so by what mechanism, and
also whether the functional form was as a homodimer. Our results show that
murine nyctalopin is anchored to the plasma membrane by a single transmembrane
domain, such that the LRR domain is located in the extracellular space
Does diabetes affect the intensity of staining of interstitial cells and neuronal tissue in the bladder, prostate and urethra of rabbits?
Untersuchungen zum Einsatz von dekantierten Feststoffen der SchweinegĂŒlle in der MastrinderernĂ€hrung
Auswirkungen von abgestufter pflanzenschutzmittelâintensitĂ€t und unkrautbesatz auf laufkĂ€ferzönosen (coleoptera; carabidae) wĂ€hrend einer fruchtfolgerotation unter den spezifischen Bedingungen des mitteldeutschen trockengebietes*
Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis
Recoil imaging for dark matter, neutrinos, and physics beyond the Standard Model
Recoil imaging entails the detection of spatially resolved ionization tracks generated by particle interactions. This is a highly sought-after capability in many classes of detector, with broad applications across particle and astroparticle physics. However, at low energies, where ionization signatures are small in size, recoil imaging only seems to be a practical goal for micro-pattern gas detectors. This white paper outlines the physics case for recoil imaging, and puts forward a decadal plan to advance towards the directional detection of low-energy recoils with sensitivity and resolution close to fundamental performance limits. The science case covered includes: the discovery of dark matter into the neutrino fog, directional detection of sub-MeV solar neutrinos, the precision study of coherent-elastic neutrino-nucleus scattering, the detection of solar axions, the measurement of the Migdal effect, X-ray polarimetry, and several other applied physics goals. We also outline the R&D programs necessary to test concepts that are crucial to advance detector performance towards their fundamental limit: single primary electron sensitivity with full 3D spatial resolution at the 100 micron-scale. These advancements include: the use of negative ion drift, electron counting with high-definition electronic readout, time projection chambers with optical readout, and the possibility for nuclear recoil tracking in high-density gases such as argon. We also discuss the readout and electronics systems needed to scale-up such detectors to the ton-scale and beyond
Recoil imaging for directional detection of dark matter, neutrinos, and physics beyond the Standard Model
Recoil imaging entails the detection of spatially resolved ionization tracks
generated by particle interactions. This is a highly sought-after capability in
many classes of detector, with broad applications across particle and
astroparticle physics. However, at low energies, where ionization signatures
are small in size, recoil imaging only seems to be a practical goal for
micro-pattern gas detectors. This white paper outlines the physics case for
recoil imaging, and puts forward a decadal plan to advance towards the
directional detection of low-energy recoils with sensitivity and resolution
close to fundamental performance limits. The science case covered includes: the
discovery of dark matter into the neutrino fog, directional detection of
sub-MeV solar neutrinos, the precision study of coherent-elastic
neutrino-nucleus scattering, the detection of solar axions, the measurement of
the Migdal effect, X-ray polarimetry, and several other applied physics goals.
We also outline the R&D programs necessary to test concepts that are crucial to
advance detector performance towards their fundamental limit: single primary
electron sensitivity with full 3D spatial resolution at the 100
micron-scale. These advancements include: the use of negative ion drift,
electron counting with high-definition electronic readout, time projection
chambers with optical readout, and the possibility for nuclear recoil tracking
in high-density gases such as argon. We also discuss the readout and
electronics systems needed to scale-up such detectors to the ton-scale and
beyond.Comment: 77 pages, 20 figures. Submitted to the Proceedings of the US
Community Study on the Future of Particle Physics (Snowmass 2021