Outlaw Murals

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Timescapes when everything happens all at once: Educator temporalities in an unequal crisis

This paper focuses on aspects of time and educators’ timescapes during the Covid-19 pandemic. It contributes to a larger discussion about changing discourses and practices of temporality both during and after a crisis, especially those enabled by technology and neoliberal contexts. Situated within the unequal and diverse South African landscape where the pandemic overturned traditional educational timescapes, the paper explores the experiences of educators from different education settings - rural, urban, school, higher education and provincial education departments and considers three interrelated questions: What did educators' timescapes look like during the crisis of the pandemic? What was the role of technology in changing educators’ timescapes? How were educational inequities manifest in the timescapes which emerged? To analyse the educators’ experiences of time, teaching with technology and networked learning during the pandemic, the paper draws on Adam’s (1998, 2004, 2021) theorisation of time. Adam argues that time is relational and composed of irreducible elements that are not always easily visible. Experiences of how time is represented or visualised include temporality, tempo and timing, as well as the past, present and future. None of the elements of time operate in isolation; they mutually implicate one another highlighting the ways in which we perceive and interpret time in our lives and the world around us. The paper discussion highlights the use of technology and networked learning linked to pedagogical changed routines and organisation that made educators readily available to their students when face-to-face interaction was not possible. While this was beneficial to students (and parents), this resulted in a blurring or conflation of educators’ work and personal lives. Educators describe experiencing time and space as scrambled, compressed and/or porous, having to negotiate new rhythms and patterns of work that require reorganising and managing their lives differently. In addition, educators reported experiencing an intensification of time and work during this period, as they struggled with the pace and tempo of teaching and learning in varied education contexts. In conclusion, the paper suggests that the unique historical circumstances of the pandemic created particular conditions for online learning with some of the technologies rapidly inserted into the education system during this period remaining uncritically in place, further highlighting the need for ongoing research in areas of time, technology and networked learning, especially in diverse and varied educational settings

Pharmaceutical “Pay-for-Delay” Reexamined: A Dwindling Practice or a Persistent Problem?

The Supreme Court ruled in FTC v. Actavis that a delay in generic entry may be anticompetitive when part of a patent settlement includes a large and otherwise unjustified value transfer to the generic company, termed a reverse payment patent settlement, or “pay-for-delay.” Following Actavis, drug companies have limited the size of reverse payments and have fashioned settlement terms that include more discreet categories of compensation to generic companies. In light of the fact that such settlements retain the potential for anticompetitive effects, the apparent size of the reverse payment may no longer be a useful gauge of the legality of pay-for-delay deals. In this Article, we argue that convoluted settlements in the post-Actavis landscape that camouflage value transfers from brand-name to generic companies necessitate a shift in the focus of antitrust scrutiny to the existence of any restriction on generic entry, together with a category of patent less likely to survive a challenge. We conclude with a discussion of pay-for-delay bills in the 116th Congress and propose several reforms to deter pay-for-delay behavior

Identification of potassium phosphite responsive miRNAs and their targets in potato

Micro RNAs (miRNAs) are small single strand non-coding RNAs that regulate geneexpression at the post-transcriptional level, either by translational inhibition or mRNA degradation based on the extent of complementarity between the miRNA and its target mRNAs. Potato (Solanum tuberosum L.) is the most important horticultural crop in Argentina. Achieving an integrated control of diseases is crucial for this crop, where frequent agrochemical applications, particularly fungicides, are carried out. A promising strategy is based on promoting induced resistance through the application ofenvironmentally friendly compounds such as phosphites, inorganic salts of phosphorous acid. The use of phosphites in disease control management has provento be effective. Although the mechanisms underlying their effect remain unclear, we postulated that miRNAs could be involved. Therefore we performed next generation sequencing (NGS) in potato leaves treated and non treated with potassium phosphite (KPhi). We identified 25 miRNAs that were expressed differentially, 14 already annotated in miRBase and 11 mapped to the potato genome as potential new miRNAs. A prediction of miRNA targets showed genes related to pathogen resistance,transcription factors, and oxidative stress. We also analyzed in silico stress and phytohormone responsive cis-acting elements on differentially expressed pre miRNAs. Despite the fact that some of the differentially expressed miRNAs have been already identified, this is to our knowledge the first report identifying miRNAs responsive to abiocompatible stress resistance inducer such as potassium phosphite, in plants.Further characterization of these miRNAs and their target genes, might help toelucidate the molecular mechanisms underlying KPhi-induced resistance.Fil: Rey Burusco, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Daleo, Gustavo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Feldman, Mariana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentin

Barriers to Dermatological Care in Patients who Received Extensive Mohs Surgery - An In-Depth Qualitative Analysis

Background: Dermatological care needs to be accessible for the elderly, but they face prominent challenges contributing to delays in diagnosis and treatment. Prolonged management of may lead to widespread cutaneous malignancies, necessitating extensive Mohs surgery. Objective: To identify areas for early intervention in the geriatric population who have undergone extensive Mohs surgery. Methods: We performed a qualitative study on 10 patients 65 years and older (68-91) from Atrium Health Wake Forest Baptist dermatology clinics between December 2022 and February 2023, who had extensive Mohs surgery (3 or more layers removed). Results: Three major areas for potential intervention for cutaneous carcinoma identified in our study were lack of knowledge, delayed care, and relationships. Discussion: Early cutaneous carcinoma intervention is essential to avoid extensive Mohs micrographic surgery and the associated risks, and to optimize patient health outcomes

Qualitative, comparative and collaborative research at large scale:The GENNOVATE Field Methodology

We present a field-tested “medium-n” qualitative comparative methodology, which enhances understanding of the strong and fluid influence of gender norms on processes of local agricultural innovation in the Global South. The GENNOVATE approach (“Enabling Gender Equality in Agricultural and Environmental Innovation”) weaves together three broad methodological challenges—context, comparison, and collaboration—and highlights how addressing the social context of innovation contributes to applied research. We discuss GENNOVATE’s analytic approach, sampling framework, data collection, and analysis procedures, and reflect critically on the research strategies adopted to document and learn from the perspectives and experiences of over 7,000 women and men in 137 villages across 26 low- and middle-income countries