What influences user continuous intention of digital museum: integrating task-technology fit (TTF) and unified theory of acceptance and usage of technology (UTAUT) models

Abstract Digital museums play a crucial role in facilitating users' access to and exploration of digital cultural heritage resources. However, exploring the factors influencing user engagement with these digital museums from a user experience perspective remains essential. This study evaluates the factors driving user continuous behavioral intention towards the digital museum of Beijing’s central axis, integrating the new task-technology fit (TTF) and the new unified theory of acceptance and use of technology (UTAUT) models, and introducing perceived enjoyment, design aesthetics, and perceived cultural value as additional variables. Analyzing survey data (n = 377) utilizing structural equation modeling (SEM), the study identifies the following key findings: (1) the task and technology characteristics of digital museums significantly impact the TTF; (2) performance expectancy, effort expectancy, design aesthetics, perceived enjoyment, and perceived cultural value all positively impact user continuous behavioral intention; (3) the technological characteristics of digital museums were observed to positively impact users' effort expectancy; but (4) the TTF and social influence did not have no significant impact the user continuous behavioral intention. These findings offer valuable insights into the factors driving users' continuous behavioral intention to use digital museums of cultural heritage, offering practical guidance for future development and optimization of these digital museums, and highlighting specific implications and suggestions for enhancing the user experience

MashFormer: A Novel Multiscale Aware Hybrid Detector for Remote Sensing Object Detection

Object detection is a critical and demanding topic in the subject of processing satellite and airborne images. The targets acquired in remote sensing imagery are at various sizes, and the backgrounds are complicated, which makes object detection extremely challenging. We address these aforementioned issues in this article by introducing the MashFormer, an innovative multiscale aware convolutional neural network (CNN) and transformer integrated hybrid detector. Specifically, MashFormer employs the transformer block to complement the CNN-based feature extraction backbone, which could obtain the relationships between long-range features and enhance the representative ability in complex background scenarios. With the intention of improving the detection performance for objects with multiscale characteristic, since in remote sensing scenarios, the size of object varies greatly. A multilevel feature aggregation component, incorporate with a cross-level feature alignment module is designed to alleviate the semantic discrepancy between features from shallow and deep layers. To verify the effectiveness of the suggested MashFormer, comparative experiments are carried out with other cutting-edge methodologies using the publicly available high resolution remote sensing detection and Northwestern Polytechnical University VHR-10 datasets. The experimental findings confirm the effectiveness and superiority of our suggested model by indicating that our approach has greater mean average precision than the other methodologies

Transport of graphene oxide in the capillary fringe: Insights from sandbox experiments and numerical simulation

Studying contaminant transport in the capillary fringe (CF), a crucial part of the vadose zone, offers insights into the mechanisms controlling pollution in soils and groundwater aquifers. This paper investigated contaminant transport in the CF by continuously injecting a conservative tracer (NaCl) and graphene oxide nanoparticle (GONP), an adsorptive contaminant, into a sandbox. After entering the CF from the unsaturated zone, both NaCl and GONP underwent lateral transport. The breakthrough curves (BTCs) for NaCl and GONP were derived from water samples collected at predetermined sampling holes. Subsequently, contaminant transport in the CF was modeled using a one-dimensional–two-dimensional (1D-2D) coupled hydrodynamic model. This model incorporated lateral dispersivity (αL = 1.198 cm) and longitudinal dispersivity (αT = 0.286 cm), calculated using a point-by-point method. The hydrodynamic dispersion coefficients obtained were then applied to the Brooks and Corey (BC) and the van Genuchten (VG) parametric models. The BC model more accurately simulated the NaCl migration compared to the VG model, leading to its application in simulating GONP transport in the CF. However, the simulated BTCs for GONP showed a lag behind the measured data, especially at high ionic strengths. This discrepancy was attributed to the variable adsorption partition coefficient of GONP under different ionic conditions. During the experiment, GONP adsorption onto the porous media's surface altered the capillary dynamics, notably increasing capillary rise height, decreasing seepage velocity, and reducing GONP dispersion. Therefore, it is necessary to consider the adsorption capacity of the contaminants in order to accurately assess their transport within the vadose zone

Corporate Sustainable Development, Corporate Environmental Performance and Cost of Debt

High environmental performance of enterprises may reduce financing costs, while good environmental performance can promote sustainable development of enterprises. Therefore, this paper examines the impact mechanism of China’s corporate environmental performance on financing costs, and whether corporate sustainable development plays a regulatory role in the research of heavy pollution industries. This study is conducted through the Breusch and Pagan Lagrange multiplier test for random effects and the Hausman test to determine whether to adopt Fixed-effects regression or Random-effects GLS regression as an estimation method to control individual effects and endogenous problems brought by time. By collecting the samples of listed companies in China from 2010 to 2021, the empirical results show that corporate environmental performance is negatively related to financing costs. Sustainable development, as a moderator variable, is negatively related to financing costs and has weakened the inhibition of corporate environmental performance on financing costs. Although the existing literature shows that environmental performance will lead to changes in debt costs, this study has made contributions to the literature by revealing the sustainable development mechanism in the relationship between corporate environmental performance and financing costs and has verified that sustainable development is one of the important factors affecting financing costs

Insights into Intramuscular Connective Tissue Associated with Wooden Breast Myopathy in Fast-Growing Broiler Chickens

Wooden breast myopathy (WBM) is a meat abnormality affecting pectoralis majors (PMs) of fast-growing broiler chickens. WBM-affected PMs exhibited varied meat qualities with increasing WBM severity. Normal PMs (NOR), mild WBM-affected PMs (MIL), moderate WBM-affected PMs (MOD), and severe WBM-affected PMs (SEV) were selected as raw materials. The structure and organization of connective tissue and fibrillar collagen were investigated through immersing with sodium hydroxide solution, Masson trichrome staining, and using an electron microscope. The mechanical strength of intramuscular connective tissue was analyzed via the shear force of samples treated with sodium hydroxide solution. The thermal property and secondary structure of connective tissue were analyzed by differential scanning calorimetry and Fourier transform infrared spectroscopy. The obtained connective tissue was dissolved in a sodium hydroxide solution for the evaluation of the physicochemical properties of proteins, including particle size, molecular weight, surface hydrophobicity, and intrinsic fluorescence. In particular, the particle size was measured using a zeta potential instrument. The molecular weight was analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. The surface hydrophobicity and intrinsic fluorescence were measured by spectroscopy technology. Histologically, macrophage infiltration, myodegeneration and necrosis, regeneration, fibrous connective tissue, and thickened perimysial connective tissue were observed in WBM-affected PMs, especially SEV with fibrosis, including blood vessels. Compared with NOR, WBM led to increased average diameter of the collagen fibrils in perimysial (36.61 nm of NOR to 69.73 nm of SEV) and endomysial (34.19 nm of NOR to 56.93 nm of SEV) layers. A significant increase (p O), 61.53 °C to 67.50 °C; maximum transition temperature (TM), 66.46 °C to 70.18 °C; termination temperature (TE), 77.20 °C to 80.88 °C) of connective tissue from NOR to SEV. Cooking decreased the mechanical strength, and MOD samples showed the highest mechanical strength (1.24 N, p p p p p p 270 kDa, 180–270 kDa, 110–180 kDa, 95–100 kDa, and <15 kDa. Taken together, WBM resulted in thickened organization, tightly packed collagen fibrils, increased mechanical strength and thermal temperature, and increased particle size, surface hydrophobicity, and intrinsic fluorescence of proteins in connective tissue, as the WBM severity increased

Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer

Abstract Background N6-methyladenosine (m6A) modification is the most abundant reversible methylation modification in eukaryotes, and it is reportedly closely associated with a variety of cancers progression, including colorectal cancer (CRC). This study showed that activated lipid metabolism and glycolysis play vital roles in the occurrence and development of CRC. However, only a few studies have reported the biological mechanisms underlying this connection. Methods Protein and mRNA levels of FTO and ALKBH5 were measured using western blot and qRT-PCR. The effects of FTO and ALKBH5 on cell proliferation were examined using CCK-8, colony formation, and EdU assays, and the effects on cell migration and invasion were tested using a transwell assay. m6A RNA immunoprecipitation (MeRIP) and RNA-seq was used to explore downstream target gene. RIP was performed to verify the interaction between m6A and HK2. The function of FTO and ALKBH5 in vivo was determined by xenograft in nude mice. Results In this study, FTO and ALKBH5 were significantly down-regulated in CRC patients and cells both in vivo and in vitro in a high-fat environment. Moreover, FTO and ALKBH5 over-expression hampered cell proliferation both in vitro and in vivo. Conversely, FTO and ALKBH5 knockdown accelerated the malignant biological behaviors of CRC cells. The mechanism of action of FTO and ALKBH5 involves joint regulation of HK2, a key enzyme in glycolysis, which was identified by RNA sequencing and MeRIP-seq. Furthermore, reduced expression of FTO and ALKBH5 jointly activated the FOXO signaling pathway, which led to enhanced proliferation ability in CRC cells. IGF2BP2, as a m6A reader, positively regulated HK2 mRNA in m6A dependent manner. Additionally, down-regulation of FTO/ALKBH5 increased METTL3 and decreased METTL14 levels, further promoting CRC progression. Conclusion In conclusion, our study revealed the FTO-ALKBH5/IGF2BP2/HK2/FOXO1 axis as a mechanism of aberrant m6A modification and glycolysis regulation in CRC