6 research outputs found
Targeted Photodynamic Therapy with a Folate/Sensitizer Assembly Produced from Mesoporous Silica
A mesoporous silica material prepared by using
folic acid (FA) as a template enables the effective encapsulation
of meso-tetrakis(4-carboxyphenyl)porphyrin (TCPP)
in its interior. Combination of steady-state and time-resolved
absorption and emission spectroscopy demonstrate
that FA and TCPP are released from the silica material
to the aqueous phase in the form of a non-covalent
assembly. This assembly does not form by simple mixing
of the two components in the absence of silica, suggesting
the key role of the material in the assembling process.
The FA/TCPP assembly exhibits dual color fluorescence in
the visible region, good photosensitization capability of
singlet oxygen, and enhanced photo-induced mortality in
KB cancer cells overexpressing folate receptor, if compared
with the free components