The Extinction and Distance of Maffei 1

We have obtained low- and high-resolution spectra of the core of the highly-reddened elliptical galaxy Maffei 1. From these data, we have obtained the first measurement of the Mg2 index, and have measured the velocity dispersion and radial velocity with improved accuracy. To evaluate the extinction, a correlation between the Mg2 index and effective V-I colour has been established for elliptical galaxies. Using a new method for correcting for effective wavelength shifts, we find A_V = 4.67 +/- 0.19 mag, which is lower by 0.4 mag than previously thought. To establish the distance, the Fundamental Plane for elliptical galaxies has been constructed in I. The velocity dispersion of Maffei 1, measured to be 186.8 +/- 7.4 km/s, in combination with modern wide-field photometry in I, leads to a distance of 2.92 +/- 0.37 Mpc. The Dn-sigma relation, which is independently calibrated, gives 3.08 +/- 0.85 Mpc and 3.23 +/- 0.67 Mpc from photometry in B and K`, respectively. The weighted mean of the three estimates is 3.01 +/- 0.30 Mpc. The distance and luminosity make Maffei 1 the nearest giant elliptical galaxy. The radial velocity of Maffei 1 is +66.4 +/- 5.0 km/s, significantly higher than the accepted value of -10 km/s. The Hubble distance corresponding to the mean velocity of Maffei 1, Maffei 2 and IC342 is 3.5 Mpc. Thus, it is unlikely that Maffei 1 has had any influence on Local Group dynamics

The Relation of Surgical Procedures and Diagnosis Groups to Unplanned Readmission in Spinal Neurosurgery: A Retrospective Single Center Study

Background: Unplanned readmission has gained increasing interest as a quality marker for inpatient care, as it is associated with patient mortality and higher economic costs. Spinal neurosurgery is characterized by a lack of epidemiologic readmission data. The aim of this study was to identify causes and predictors for unplanned readmissions related to index diagnoses and surgical procedures. Methods: In this study, from 2015 to 2017, spinal neurosurgical procedures were recorded for surgical and non-surgical treated patients. The main reasons for an unplanned readmission within 30 days following discharge were identified. Multivariate logarithmic regression revealed predictors of unplanned readmission. Results: A total of 1172 patient records were examined, of which 4.27% disclosed unplanned readmissions. Among the surgical patients, the readmission rate was 4.06%, mainly attributable to surgical site infections, while it was 5.06% for the non-surgical patients, attributable to uncontrolled pain. A night-time surgery presented as the independent predictive factor. Conclusion: In the heterogeneous group of spinal neurosurgical patients, stratification into diagnostic groups is necessary for statistical analysis. Degenerative lumbar spinal stenosis and spinal abscesses are mainly affected by unplanned readmission. The surgical procedure dorsal root ganglion stimulation is an independent predictor of unplanned re-hospitalizations, as is the timing of surgery

Chromospheric activity, lithium and radial velocities of single late-type stars possible members of young moving groups

We present here high resolution echelle spectra taken during three observing runs of 14 single late-type stars identified in our previous studies (Montes et al. 2001b, hereafter Paper I) as possible members of different young stellar kinematic groups (Local Association (20 - 150 Myr), Ursa Major group (300 Myr), Hyades supercluster (600 Myr), and IC 2391 supercluster (35 Myr)). Radial velocities have been determined by cross correlation with radial velocity standard stars and used together with precise measurements of proper motions and parallaxes taken from Hipparcos and Tycho-2 Catalogues, to calculate Galactic space motions (U, V, W) and to apply Eggen's kinematic criteria. The chromospheric activity level of these stars have been analysed using the information provided for several optical spectroscopic features (from the Ca II H & K to Ca II IRT lines) that are formed at different heights in the chromosphere. The Li I 6707.8 AA line equivalent width (EW) has been determined and compared in the EW(Li I) versus spectral type diagram with the EW(Li I) of stars members of well known young open clusters of different ages, in order to obtain an age estimation. All these data allow us to analyse in more detail the membership of these stars in the different young stellar kinematic groups. Using both kinematic and spectroscopic criteria we have confirmed PW And, V368 Cep, V383 Lac, EP Eri, DX Leo, HD 77407, and EK Dra as members of the Local Association and V834 Tau, pi^{1} UMa, and GJ 503.2 as members of the Ursa Major group. A clear rotation-activity dependence has been found in these stars.Comment: Latex file with 19 pages, 7 figures tar'ed gzip'ed. Full postscript (text, figures and tables) available at http://www.ucm.es/info/Astrof/p_skg_stars_I_fv.ps.gz Accepted for publication in: Astronomy & Astrophysics (A&A

Atmospheric parameters and pulsational properties for a sample of δ\delta\,Sct, γ\gamma\,Dor, and hybrid {\it Kepler} targets

We report spectroscopic observations for 19 $\delta$\,Sct candidates observed by the {\it Kepler} satellite both in long and short cadence mode. For all these stars, by using spectral synthesis, we derive the effective temperature, the surface gravity and the projected rotational velocity. An equivalent spectral type classification has been also performed for all stars in the sample. These determinations are fundamental for modelling the frequency spectra that will be extracted from the {\it Kepler} data for asteroseismic inference. For all the 19 stars, we present also periodograms obtained from {\it Kepler} data. We find that all stars show peaks in both low- ($\gamma$\,Dor; g mode) and high-frequency ($\delta$\,Sct; p mode) regions. Using the amplitudes and considering 5\,c/d as a boundary frequency, we classified 3 stars as pure $\gamma$\,Dor, 4 as $\gamma$\,Dor\,-\,$\delta$\ hybrid, Sct, 5 as $\delta$\,Sct\,-\,$\gamma$\,Dor hybrid, and 6 as pure $\delta$\,Sct. The only exception is the star KIC\,05296877 which we suggest could be a binary.Comment: 11 pages, 6 figures, MNRAS main journa

Influence of aerobic fitness on gastrointestinal barrier integrity and microbial translocation following a fixed-intensity military exertional heat stress test

Purpose: Exertional-heat stress adversely disrupts gastrointestinal (GI) barrier integrity, whereby subsequent microbial translocation (MT) can result in potentially serious health consequences. To date, the influence of aerobic fitness on GI barrier integrity and MT following exertional-heat stress is poorly characterised. Method: Ten untrained (UT; VO2max = 45 ± 3 ml·kg−1·min−1) and ten highly trained (HT; VO2max = 64 ± 4 ml·kg−1·min−1) males completed an ecologically valid (military) 80-min fixed-intensity exertional-heat stress test (EHST). Venous blood was drawn immediately pre- and post-EHST. GI barrier integrity was assessed using the serum dual-sugar absorption test (DSAT) and plasma Intestinal Fatty-Acid Binding Protein (I-FABP). MT was assessed using plasma Bacteroides/total 16S DNA. Results: UT experienced greater thermoregulatory, cardiovascular and perceptual strain (p < 0.05) than HT during the EHST. Serum DSAT responses were similar between the two groups (p = 0.59), although Δ I-FABP was greater (p = 0.04) in the UT (1.14 ± 1.36 ng·ml−1) versus HT (0.20 ± 0.29 ng·ml−1) group. Bacteroides/Total 16S DNA ratio was unchanged (Δ; -0.04 ± 0.18) following the EHST in the HT group, but increased (Δ; 0.19 ± 0.25) in the UT group (p = 0.05). Weekly aerobic training hours had a weak, negative correlation with Δ I-FABP and Bacteroides/total 16S DNA responses. Conclusion: When exercising at the same absolute workload, UT individuals are more susceptible to small intestinal epithelial injury and MT than HT individuals. These responses appear partially attributable to greater thermoregulatory, cardiovascular, and perceptual strain

The Relation of Surgical Procedures and Diagnosis Groups to Unplanned Readmission in Spinal Neurosurgery: A Retrospective Single Center Study

Background: Unplanned readmission has gained increasing interest as a quality marker for inpatient care, as it is associated with patient mortality and higher economic costs. Spinal neurosurgery is characterized by a lack of epidemiologic readmission data. The aim of this study was to identify causes and predictors for unplanned readmissions related to index diagnoses and surgical procedures. Methods: In this study, from 2015 to 2017, spinal neurosurgical procedures were recorded for surgical and non-surgical treated patients. The main reasons for an unplanned readmission within 30 days following discharge were identified. Multivariate logarithmic regression revealed predictors of unplanned readmission. Results: A total of 1172 patient records were examined, of which 4.27% disclosed unplanned readmissions. Among the surgical patients, the readmission rate was 4.06%, mainly attributable to surgical site infections, while it was 5.06% for the non-surgical patients, attributable to uncontrolled pain. A night-time surgery presented as the independent predictive factor. Conclusion: In the heterogeneous group of spinal neurosurgical patients, stratification into diagnostic groups is necessary for statistical analysis. Degenerative lumbar spinal stenosis and spinal abscesses are mainly affected by unplanned readmission. The surgical procedure dorsal root ganglion stimulation is an independent predictor of unplanned re-hospitalizations, as is the timing of surgery

The Relation of Surgical Procedures and Diagnosis Groups to Unplanned Readmission in Spinal Neurosurgery: A Retrospective Single Center Study

Background: Unplanned readmission has gained increasing interest as a quality marker for inpatient care, as it is associated with patient mortality and higher economic costs. Spinal neurosurgery is characterized by a lack of epidemiologic readmission data. The aim of this study was to identify causes and predictors for unplanned readmissions related to index diagnoses and surgical procedures. Methods: In this study, from 2015 to 2017, spinal neurosurgical procedures were recorded for surgical and non-surgical treated patients. The main reasons for an unplanned readmission within 30 days following discharge were identified. Multivariate logarithmic regression revealed predictors of unplanned readmission. Results: A total of 1172 patient records were examined, of which 4.27% disclosed unplanned readmissions. Among the surgical patients, the readmission rate was 4.06%, mainly attributable to surgical site infections, while it was 5.06% for the non-surgical patients, attributable to uncontrolled pain. A night-time surgery presented as the independent predictive factor. Conclusion: In the heterogeneous group of spinal neurosurgical patients, stratification into diagnostic groups is necessary for statistical analysis. Degenerative lumbar spinal stenosis and spinal abscesses are mainly affected by unplanned readmission. The surgical procedure dorsal root ganglion stimulation is an independent predictor of unplanned re-hospitalizations, as is the timing of surgery

The Relation of Surgical Procedures and Diagnosis Groups to Unplanned Readmission in Spinal Neurosurgery: A Retrospective Single Center Study

Background: Unplanned readmission has gained increasing interest as a quality marker for inpatient care, as it is associated with patient mortality and higher economic costs. Spinal neurosurgery is characterized by a lack of epidemiologic readmission data. The aim of this study was to identify causes and predictors for unplanned readmissions related to index diagnoses and surgical procedures. Methods: In this study, from 2015 to 2017, spinal neurosurgical procedures were recorded for surgical and non-surgical treated patients. The main reasons for an unplanned readmission within 30 days following discharge were identified. Multivariate logarithmic regression revealed predictors of unplanned readmission. Results: A total of 1172 patient records were examined, of which 4.27% disclosed unplanned readmissions. Among the surgical patients, the readmission rate was 4.06%, mainly attributable to surgical site infections, while it was 5.06% for the non-surgical patients, attributable to uncontrolled pain. A night-time surgery presented as the independent predictive factor. Conclusion: In the heterogeneous group of spinal neurosurgical patients, stratification into diagnostic groups is necessary for statistical analysis. Degenerative lumbar spinal stenosis and spinal abscesses are mainly affected by unplanned readmission. The surgical procedure dorsal root ganglion stimulation is an independent predictor of unplanned re-hospitalizations, as is the timing of surgery

Generation and Validation of a Limited Sampling Strategy to Monitor Mycophenolic Acid Exposure in Children With Nephrotic Syndrome

Background: Mycophenolate mofetil (MMF) plays an increasingly important role in the treatment of children with nephrotic syndrome, especially in steroid sparing protocols. Recent publications show the relationship of exposure to its active moiety mycophenolic acid (MPA) and clinical efficacy. Performance of full-time pharmacokinetic (PK) profiles, however, is inconvenient and laborious. Established limited sampling strategies (LSS) to estimate the area under the concentration (AUC) versus time curve of MPA (MPA-AUC) in pediatric renal transplant recipients cannot be easily transferred to children suffering from nephrotic syndrome, mainly because of the lack of concomitant immunosuppressive therapy. We therefore aimed for the generation and validation of a LSS to estimate MPA exposure to facilitate therapeutic drug monitoring in children with nephrotic syndrome. Methods: We performed 27 complete PK profiles in 23 children in remission [mean age (+/- SD):12.3 +/- 4.26 years] to generate and validate an LSS. Sampling time points were before administration (C-0) and 0.5, 1, 1.5, 2, 4, 6, 8, and 12 hours after the administration of MMF. MPA was measured by enzyme multiplied immunoassay technique. There was no concomitant treatment with calcineurin inhibitors. Results: Mean daily dose of MMF was 927 +/- 209 mg/m(2) of body surface area resulting in a mean MPA-AUC(0-12) value of 59.2 +/- 29.3 mg x h/L and a predose level of 3.03 +/- 2.24 mg/L. Between-patient variability of dose-normalized MPA-AUC(0-12) was high (coefficient of variation: 45.5%). Correlation of predose levels with the corresponding MPA-AUC(0-12) was moderate (r(2) = 0.59) in a subgroup of 18 patients (20 PK profiles, generation group). An algorithm based on 3 PK sampling time points during the first 2 hours after MMF dosing (estimated AUC(0-12) = 8.7 + 4.63 x C-0 + 1.90 x C-1 + 1.52 x C-2) was able to predict MPA-AUC with a low percentage prediction error (3.88%) and a good correlation of determination (r(2) = 0.90). Validation of this algorithm in a randomized separate group of 6 patients (7 PK profiles, validation group) resulted in comparably good correlation (r(2) = 0.95) and low percentage prediction error (5.57%). Conclusions: An abbreviated profile within the first 2 hours after MMF dosing gives a good estimate of MPA exposure in children with nephrotic syndrome and hence has the potential to optimize MMF therapy