Studying the Impact of the Genetic Polymorphisms of Chemokines on the Arterial Pressure Level and Kidney Function in Patient with the Chronic Glomerulonephritis

ABSTRACT The associations of polymorphisms of the chemokine genes (+1931А/Т MIP1β, A/G I-TAC (rs4512021), -403A/G RANTES, C/G MCP1 (rs2857657), -801G/A SDF1) with arterial hypertension and renal insufficiency were investigated in 238 patients with chronic glomerulonephritis and 462 individuals of the control group. It has been established that the genetic marker А I-TAC (rs 4512021) is the risk factor for genesis of the severe arterial hypertension at the chronic glomerulonephritis (OR=1,65) and the genotypes АА and AG I-TAC are the risk factors of depression of the kidney function