468 research outputs found
Density Variations over Subparsec Scales in Diffuse Molecular Gas
We present high-resolution observations of interstellar CN, CH, CH^{+},
\ion{Ca}{1}, and \ion{Ca}{2} absorption lines toward the multiple star systems
HD206267 and HD217035. Substantial variations in CN absorption are observed
among three sight lines of HD206267, which are separated by distances of order
10,000 AU; smaller differences are seen for CH, CH^{+}, and \ion{Ca}{1}. Gas
densities for individual velocity components are inferred from a chemical
model, independent of assumptions about cloud shape. While the component
densities can differ by factors of 5.0 between adjacent sightlines, the
densities are always less than 5000 cm^{-3}. Calculations show that the derived
density contrasts are not sensitive to the temperature or reaction rates used
in the chemical model. A large difference in the CH^{+} profiles (a factor of 2
in column density) is seen in the lower density gas toward HD217035.Comment: 9 pages, 2 figures. Accepted for publication in ApJ
OH+ in Diffuse Molecular Clouds
Near ultraviolet observations of OH+ and OH in diffuse molecular clouds
reveal a preference for different environments. The dominant absorption feature
in OH+ arises from a main component seen in CH+ (that with the highest CH+/CH
column density ratio), while OH follows CN absorption. This distinction
provides new constraints on OH chemistry in these clouds. Since CH+ detections
favor low-density gas with small fractions of molecular hydrogen, this must be
true for OH+ as well, confirming OH+ and H2O+ observations with the Herschel
Space Telescope. Our observed correspondence indicates that the cosmic ray
ionization rate derived from these measurements pertains to mainly atomic gas.
The association of OH absorption with gas rich in CN is attributed to the need
for high enough density and molecular fraction before detectable amounts are
seen. Thus, while OH+ leads to OH production, chemical arguments suggest that
their abundances are controlled by different sets of conditions and that they
coexist with different sets of observed species. Of particular note is that
non-thermal chemistry appears to play a limited role in the synthesis of OH in
diffuse molecular clouds.Comment: 15 pages, 4 figures, to appear in ApJ Letter
Generalization of the Scheme and the Structure of the Valence Space
The scheme, which has been extensively applied to even-even nuclei,
is found to be a very good benchmark for odd-even, even-odd, and doubly-odd
nuclei as well. There are no apparent shifts in the correlations for these four
classes of nuclei. The compact correlations highlight the deviant behavior of
the Z=78 nuclei, are used to deduce effective valence proton numbers near Z=64,
and to study the evolution of the Z=64 subshell gap.Comment: 10 pages, 4 figure
The Effects of Doubly Ionized Chemistry on SH+ and S^+2 Abundances in X-ray Dominated Regions
Recent laboratory measurements for the S^+2 + H2 reaction find a total rate
coefficient significantly larger than previously used in theoretical models of
X-ray dominated regions (XDRs). While the branching ratio of the products is
unknown, one energetically possible route leads to the SH+ molecule, a known
XDR diagnostic. In this work, we study the effects of S^+2 on the formation of
SH+ and the destruction of S^+2 in XDRs. We find the predicted SH+ column
density for molecular gas surrounding an Active Galactic Nucleus (AGN)
increases by as much as 2 dex. As long as the branching ratio for S^+2 + H2 ->
SH+ + H+ exceeds a few percent, doubly ionized chemistry will be the dominant
pathway to SH+, which then initiates the formation of other sulfur-bearing
molecules. We also find that the high rate of S^+2 + H2 efficiently destroys
S^+2 once H2 forms, while the S^+2 abundance remains high in the atomic
hydrogen region. We discuss the possible consequences of S^+2 in the atomic
hydrogen region on mid-infrared diagnostics. The enhanced SH+ abundance has
important implications in the study of XDRs, while our conclusions for S^+2
could potentially impact the interpretation of Spitzer and SOFIA observations.Comment: 19 pages, 3 figures, Accepted for Publication in ApJ Letter
Oscillator Strengths for B-X, C-X, and E-X Transitions in Carbon Monoxide
Band oscillator strengths for electronic transitions in CO were obtained at
the Synchrotron Radiation Center of the University of Wisconsin-Madison. Our
focus was on transitions that are observed in interstellar spectra with the Far
Ultraviolet Spectroscopic Explorer; these transitions are also important in
studies of selective isotope photodissociation where fractionation among
isotopomers can occur. Absorption from the ground state (X ^1Sigma^+ v'' = 0)
to A ^1Pi (v'= 5), B ^1Sigma^+ (v' = 0, 1), C ^1Sigma^+ (v' = 0, 1), and E ^1Pi
(v' = 0) was measured. Fits to the A - X (5, 0) band, whose oscillator strength
is well known, yielded the necessary column density and excitation temperature.
These parameters were used in a least-squares fit of the observed profiles for
the transitions of interest to extract their band oscillator strengths. Our
oscillator strengths are in excellent agreement with results from recent
experiments using a variety of techniques. This agreement provides the basis
for a self-consistent set of f-values at far ultraviolet wavelengths for
studies of interstellar (and stellar) CO.Comment: 22 pages, 3 figures, ApJS (in press
Larotrectinib efficacy and safety in TRK fusion cancer: An expanded clinical dataset showing consistency in an age and tumor agnostic approach
Background: TRK fusion cancer results from gene fusions involving NTRK1, NTRK2 or NTRK3. Larotrectinib, the first selective TRK inhibitor, has demonstrated an overall response rate (ORR) of 75% with a favorable safety profile in the first 55 consecutively enrolled adult and pediatric patients with TRK fusion cancer (Drilon et al.,NEJM2018). Here, we report the clinical activity of larotrectinib in an additional 35 TRK fusion cancer patients and provide updated follow-up of the primary analysis set (PAS) of 55 patients as of 19thFeb 2018. Methods: Patients with TRK fusion cancer detected by molecular profiling from 3 larotrectinib clinical trials (NCT02122913, NCT02637687, and NCT02576431) were eligible.Larotrectinib was administered until disease progression, withdrawal, or unacceptable toxicity. Disease status was assessed using RECIST version 1.1. Results: As of Feb 2018, by independent review, 6 PRs in the PAS deepened to CRs. The median duration of response (DoR) and progression-free survival in the PAS had still not been reached, with 12.9 months median follow-up. At 1 year, 69% of responses were ongoing, 58% of patients remained progression-free and 90% of patients were alive. An additional 19 children and 25 adults (age range, 0.1-78 years) with TRK fusion cancer were enrolled after the PAS, and included cancers of the salivary gland, thyroid, lung, colon, melanoma, sarcoma, GIST and congenital mesoblastic nephroma. In 35 evaluable patients, the ORR by investigator assessment was 74% (5 CR, 21 PR, 6 SD, 2 PD, 1 not determined). In these patients, with median follow-up of 5.5 months, median DoR had not yet been reached, and 88% of responses were ongoing at 6 months, consistent with the PAS. Adverse events (AEs) were predominantly grade 1, with dizziness, increased AST/ALT, fatigue, nausea and constipation the most common AEs reported in ≥ 10% of patients. No AE of grade 3 or 4 related to larotrectinib occurred in more than 5% of patients. Conclusions: TRK fusions are detected in a broad range of tumor types. Larotrectinib is an effective age- and tumor-agnostic treatment for TRK fusion cancer with a positive safety profile. Screening patients for NTRK gene fusions in solid- and brain tumors should be actively considered
Universality of Symmetry and Mixed-symmetry Collective Nuclear States
The global correlation in the observed variation with mass number of the
and summed transition strengths is examined for rare earth nuclei. It is
shown that a theory of correlated and fermion pairs with a simple
pairing plus quadrupole interaction leads naturally to this universality. Thus
a unified and quantitative description emerges for low-lying quadrupole and
dipole strengths.Comment: In press, Phys. Rev. Lett. 199
Electron-Ion Recombination on Grains and Polycyclic Aromatic Hydrocarbons
With the high-resolution spectroscopy now available in the optical and
satellite UV, it is possible to determine the neutral/ionized column density
ratios for several different elements in a single cloud. Assuming ionization
equilibrium for each element, one can make several independent determinations
of the electron density. For the clouds for which such an analysis has been
carried out, these different estimates disagree by large factors, suggesting
that some process (or processes) besides photoionization and radiative
recombination might play an important role in the ionization balance. One
candidate process is collisions of ions with dust grains.
Making use of recent work quantifying the abundances of polycyclic aromatic
hydrocarbon molecules and other grains in the interstellar medium, as well as
recent models for grain charging, we estimate the grain-assisted ion
recombination rates for several astrophysically important elements. We find
that these rates are comparable to the rates for radiative recombination for
conditions typical of the cold neutral medium. Including grain-assisted ion
recombination in the ionization equilibrium analysis leads to increased
consistency in the various electron density estimates for the gas along the
line of sight to 23 Orionis. However, not all of the discrepancies can be
eliminated in this way; we speculate on some other processes that might play a
role. We also note that grain-assisted recombination of H+ and He+ leads to
significantly lower electron fractions than usually assumed for the cold
neutral medium.Comment: LaTeX(12 pages, 8 figures, uses emulateapj5.sty, apjfonts.sty);
submitted to ApJ; corrected typo
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